用法及用量
口服：１次0.1g，１日２次。必要时首剂可加倍。８岁以上儿童：首剂每千克体重４ｍｇ；以后，每次每千克体重２ｍｇ，１日２次。一般疗程为３～７日。预防恶性疟：每周0.1g；预防勾端螺旋体病：每周２次，每次0.1g。

不良反应和注意
1.胃肠道反应多见（约２０％），如恶心、呕吐、腹泻等，饭后服药可减轻。
2.其他不良反应参见四环素。
3.用法应为１日２次，如每日应用0.1g1次，不足以维持有效血药浓度。
4.在肝、肾功能轻度不全者，本药的半衰期与在正常者无显著区别，但对肝、肾功能重度不全者则应注意慎用。
5.对８岁以下小儿及孕妇、哺乳妇女一般应禁用。

【原产地英文商品名】VIBRAMYCIN Oral Suspension 25mg/5ml 60ml/bottle
【原产地英文药品名】DOXYCYCLINE MONOHYDRATE
【中文参考商品译名】VIBRAMYCIN口服混悬剂 25毫克/5毫升 60毫升/瓶
【中文参考药品译名】强力霉素一水化物
【生产厂家中文参考译名】辉瑞
【生产厂家英文名】Pfizer

Vibramycin
Generic Name: doxycycline (DOX i SYE kleen)
Brand Names: Adoxa, Alodox, Avidoxy, Doryx, Monodox, Oracea, Oraxyl, Periostat, Vibra-Tabs, Vibramycin, Vibramycin Calcium, Vibramycin Monohydrate

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What is Vibramycin (doxycycline)?
Doxycycline is a tetracycline antibiotic. It fights bacteria in the body.

Doxycycline is used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, and chlamydia, periodontitis (gum disease), and others.

Doxycycline is also used to treat blemishes, bumps, and acne-like lesions caused by rosacea. Doxycycline will not treat facial redness caused by rosacea.

Doxycycline may also be used for other purposes not listed in this medication guide.

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What is the most important information I should know about Vibramycin (doxycycline)?
Do not use this medication if you are pregnant. It could cause harm to the unborn baby, including permanent discoloration of the teeth later in life. Doxycycline can make birth control pills less effective. Use a second method of birth control while you are taking doxycycline to keep from getting pregnant. Doxycycline passes into breast milk and may affect bone and tooth development in a nursing baby. Do not take this medication without telling your doctor if you are breast-feeding a baby. Do not use this medication if you are allergic to doxycycline, or to similar medicines such as demeclocycline (Declomycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap). Before taking doxycycline, tell your doctor if you have liver or kidney disease. You may not be able to take doxycycline, or you may need a dose adjustment or special tests during treatment. Do not give doxycycline to a child younger than 8 years old. Doxycycline can cause permanent yellowing or graying of the teeth, and it can affect a child's growth. Throw away any unused doxycycline when it expires or when it is no longer needed. Do not take any doxycycline after the expiration date printed on the bottle. Expired doxycycline can cause a dangerous syndrome resulting in damage to the kidneys.

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What should I discuss with my healthcare provider before taking Vibramycin (doxycycline)?
Do not use this medication if you are allergic to doxycycline, or to similar medicines such as demeclocycline (Declomycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap). If you have liver or kidney disease, you may need a dose adjustment or special tests to safely take doxycycline.

If you are using doxycycline to treat gonorrhea, your doctor may test you to make sure you do not also have syphilis, another sexually transmitted disease.

Do not use doxycycline syrup (Vibramycin) without first talking to your doctor if you have asthma or are allergic to sulfites.

FDA pregnancy category D. This medication can cause harm to an unborn baby, including permanent discoloration of the teeth later in life. Do not use doxycycline without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Doxycycline can make birth control pills less effective. Use a non-hormonal method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while you are taking doxycycline. Doxycycline passes into breast milk and may affect bone and tooth development in a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. Children younger than 8 years old should not take doxycycline. Doxycycline can cause permanent tooth discoloration and can also affect a child's growth

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How should I take Vibramycin (doxycycline)?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take doxycycline with a full glass of water (8 ounces).

You may take this medication with or without food. Do not take the medication with milk or other dairy products, unless your doctor has told you to. Dairy products can make it harder for your body to absorb the medicine. Certain brands of doxycycline may not have restrictions about taking them with dairy products. If your doctor has instructed you to take doxycycline with milk, tell your pharmacist that you need a brand of doxycycline that can be taken with milk.

Do not crush, break, or open a delayed-release capsule (Orecea). Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time. Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Doxycycline will not treat a viral infection such as the common cold or flu. Do not give this medicine to another person, even if they have the same condition you have.

If you need to have any type of surgery, tell the surgeon ahead of time that you are taking doxycycline. You may need to stop using the medicine for a short time.

Throw away any unused doxycycline when it expires or when it is no longer needed. Do not take any doxycycline after the expiration date printed on the label. Using expired doxycycline can cause damage to your kidneys. Store this medication at room temperature away from moisture and heat.

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What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

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What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, and diarrhea.

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What should I avoid while taking Vibramycin (doxycycline)?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Doxycycline can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun. Do not take iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking doxycycline.

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Vibramycin (doxycycline) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using doxycycline and call your doctor at once if you have any of these serious side effects:
severe headache, dizziness, blurred vision;
fever, chills, body aches, flu symptoms;
severe blistering, peeling, and red skin rash;
urinating less than usual or not at all;
pale or yellowed skin, dark colored urine, fever, confusion or weakness;
severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
loss of appetite, jaundice (yellowing of the skin or eyes); or
easy bruising or bleeding, unusual weakness.

Less serious side effects may include:
swollen tongue, trouble swallowing;
mild nausea, vomiting, diarrhea, or stomach upset;
white patches or sores inside your mouth or on your lips;
sores or swelling in your rectal or genital area; or
vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

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What other drugs will affect Vibramycin (doxycycline)?
Before taking doxycycline, tell your doctor if you are taking any of the following drugs:
cholesterol-lowering medications such as cholestyramine (Prevalite, Questran) or colestipol (Colestid);
isotretinoin (Accutane);
tretinoin (Renova, Retin-A, Vesanoid);
an antacid such as Tums, Rolaids, Milk of Magnesia, Maalox, and others;
a product that contains bismuth subsalicylate such as Pepto-Bismol;
minerals such as iron, zinc, calcium, magnesium, and over-the-counter vitamin and mineral supplements;
a blood thinner such as warfarin (Coumadin); or
a penicillin antibiotic such as amoxicillin (Amoxil, Trimox, others), penicillin (BeePen-VK, Pen-Vee K, Veetids, others), dicloxacillin (Dynapen), oxacillin (Bactocill), and others.

This list is not complete and there may be other drugs that can interact with doxycycline. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Where can I get more information?
Your pharmacist can provide more information about doxycycline.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.