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英文药名：FOSMICIN-S FOR INJECTION（Fosfomycin Sodium）
中文药名：磷霉素钠注射粉末剂
生产厂家：明治制果制药
类别名称
磷霉素抗菌配方
欧文商標名
FOSMICIN-S 0.5g FOR INJECTION
FOSMICIN-S 1g FOR INJECTION
FOSMICIN-S 2g FOR INJECTION
一般名
ホスホマイシンナトリウム
Fosfomycin Sodium
性 状
磷霉素钠是一种白色结晶粉末。
这是非常易溶于水，稍少溶于甲醇，和乙醇（99.5）几乎不溶。
略 号
FOM
化学名
Disodium(2R,3S)-3-methyloxiran-2-ylphosphonate
分子式
C3H5Na2O4P
分子量
182.02
構造式
分配係数
（log10 １-オクタノール層/水層、20±５℃）
(下表参照)
操作注意事项
虽然它可能变热，产生的溶液的热量在该药物的溶解时间，它不影响质量。
药效药理
1. 体外抗菌作用
磷霉素，革兰氏阳性菌，对于阴性菌的杀菌作用。特别是，它表明铜绿假单胞菌，变形杆菌，摩根氏Morugani，粘质沙雷氏菌和多药耐药的金黄色葡萄球菌，大肠杆菌中优异的抗菌活性。
2.作用机序
磷霉素的作用机制是非常独特。换句话说，磷霉素取入细胞内有效地通过细胞膜的主动转运系统，以及通过抑制细胞壁肽聚糖的生物合成的早期阶段表现出抗微生物活性。
（Β内酰胺抗生素以抑制在最后阶段）。
适应症
金黄色葡萄球菌感性磷霉素，大肠杆菌，沙雷菌属，变形杆菌属，摩根Morugani，普罗维登Rettogeri，铜绿假单胞菌
主治
败血症，急性支气管炎，肺炎，肺脓肿，脓胸，慢性呼吸道病变继发感染，膀胱炎，肾盂肾炎，腹膜炎，前庭大腺炎症，宫腔感染，子宫附件炎，子宫壁结缔组织炎
剂量和给药方法
[滴灌静脉注射]
每日2〜4克（效价），为磷霉素成人，每日也分为100〜200毫克（效价）/公斤两次在儿童，溶解在补液100〜500毫升，和1-2和点滴静脉注射一段时间。
[静脉]
2〜4克（效价）的第一如磷霉素成人和100〜200毫克（效价）每日为儿童/千克分为2至4次，和静脉内注射慢慢历时5分钟到。使用天站注射用水或天站葡萄糖注射液溶解，这种药物1〜2克的（效价）予溶解在20毫升。此外，将被增加或减少取决于患者的年龄，症状在任何一种情况下。
包装规格
FOSMICIN-S 0.5克
1瓶 500毫克（效价），含10瓶
FOSMICIN-S 1克
1小瓶 1克（效价），含10瓶
FOSMICIN-S 2克
1小瓶 2克（效价），含10瓶
生产商：明治制果制药
FOSMICIN-S FOR INJECTION（Fosfomycin Sodium）
FOSMICIN-S 0.5g FOR INJECTION（ホスミシンS静注用0.5g）
Brand name : FOSMICIN-S 0.5g FOR INJECTION
Active ingredient: Fosfomycin sodium
Dosage form: injection
Print on wrapping:
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FOSMICIN-S 1g FOR INJECTION（ホスミシンS静注用1g）
Brand name : FOSMICIN-S 1g FOR INJECTION
Active ingredient: Fosfomycin sodium
Dosage form: injection
Print on wrapping:
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FOSMICIN-S 2g FOR INJECTION（ホスミシンS静注用2g）
Brand name : FOSMICIN-S 2g FOR INJECTION
Active ingredient: Fosfomycin sodium
Dosage form: injection
Print on wrapping:
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Effects of this medicine
This medicine is a fosfomycin antibiotic, which inhibits bacterial cell wall synthesis in its early stage to exert an antibacterial effect.
It is usually used to treat a wide range of infections such as blood infection, respiratory infection, urinary tract infection and gynecological infection.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you or your family has the predisposition to allergic symptoms such as bronchial asthma, rash and hives.
If you have liver disorder.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, this medicine is administered by intravenous infusion over a period of 1 to 2 hours in 2 divided doses a day or injected intravenously over a period of 5 minutes or longer in 2 to 4 divided doses a day.
•The treatment period with this medicine is determined based on your symptoms.
•Relax and stay still while receiving drip infusion.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
The most commonly reported adverse reactions include rash, itching, hives, diarrhea, nausea, vomiting, abdominal pain, loss of appetite, vascular pain, flush, fever, malaise, renal dysfunction and hypesthesia. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•distressed feeling of chest, respiratory distress, falling of blood pressure [shock, anaphylactoid symptoms]
•abdominal pain, frequent diarrhea [serious colitis with bloody stool such as pseudomembranous colitis]
•palpitation/shortness of breath, sore throat, gum bleeding [pancytopenia, agranulocytosis, thrombocytopenia]
•general malaise, loss of appetite, yellowing of the skin and the white of eyes [liver dysfunction, jaundice]
•sudden attacks of muscular spasms [convulsion]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•If you become unwell during an injection, you should tell your doctor immediately.
http://www.info.pmda.go.jp/go/pack/6135400F1051_1_05/
Meiji Seika Pharma Co., Ltd.Injection
Published: 3/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
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