英文药名：hCRH "TANABE" Injection（Corticotropin[human]） 中文药名：可的瑞林注射液 日文药名：ヒトCRH静注用 生产厂家：田边三菱制药 治疗类别名称 下丘脑 - 垂体 - 肾上腺皮质系统的激素分泌功能试验药物 欧文商標名 hCRH "TANABE" Injection 100μg 一般名 コルチコレリン（ヒト），Corticorelin（human）（JAN） 化学名 コルチコトロピン放出ホルモン（ヒト） Corticotropin-releasing hormone（human） 分子式 C208H344N60O63S2分子量 4757.47 構造式 Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2 性状 为白色粉末或质量。微溶于水，微溶于乙醇中（95），并在乙醚中几乎不溶 适应病症 下丘脑 - 垂体 - 肾上腺皮质系统激素分泌功能检查 <判断标准> 然后，判断从血液ACTH水平及血皮质醇值进行。 血液的ACTH值测定方法中，如果这是因为不同的正常反应由诸如测试执行时间应在单个设施进行设置，通常，在正常的人，这是在测试上午9点左右进行，通过放射免疫是三次给药前值在给药顺序在测量达到在30分钟内的最高浓度在给药后15PG /毫升之前。但是，政府不能充分确定之后，就认为只有30分钟时血中ACTH值时，测得在给药后确定的时间。 血液皮质醇值测定方法中，如果这是因为不同的正常反应由诸如测试执行时间应在单个设施进行设置，通常，在正常的人，这是在测试上午9点左右进行，通过放射免疫通过在约先前施用10μg的到达在给药后60分钟内的最高浓度的测量/dL的是两倍于给药前的值。但是，政府不能充分确定之后，就认为只有60分钟时血中皮质醇时，测量在给药后确定的时间。 用法用量 这种药物溶解在生理盐水1毫升的100μG针对成人，儿童空腹清晨每身体重1kg的为1.5μg，过了静脉注射约30秒缓缓注入。 药效药理 在使用垂体肾上腺皮质激素和肾上腺皮质碳水化合物文化类固醇激素分泌作用的大鼠垂体前叶细胞的体外研究，这剂在浓度依赖性ACTH分泌升任。 当这种药物在正常大鼠静脉内给药，皮质酮的ACTH和血液浓度在大鼠的主要碳水化合物类固醇激素是剂量依赖性的增加。 包装规格 人类CRH静脉 100μg*1瓶（+1毫升生理盐水） 生产商： 田边三菱制药 Product Name: human CRH intravenous 100μg "Tanabe" Active ingredient: corticorelin (Corticorelin)  Dosage form: injection  Described sheet: Effects of this medicine In synthesized corticotropin releasing hormone (CRH), to promote the production and secretion of adrenocorticotropic hormone of the anterior pituitary (ACTH), secreted ACTH promotes the production and secretion of cortisol adrenal cortex. It is usually used in the hypothalamus-pituitary-adrenal cortex hormone secretion function tests.  Please tell your doctor and pharmacist before certainly responsible for the following people to use. • Before using this medicine, itch, there is the fact that out allergy symptoms such as rash. • If you are pregnant or breastfeeding. • other you are using, such as medicine (you can strengthen the effect on each other, so there is also likely to weaken, please note, including OTC drugs and food in use in the other). Dosage regimen (proper use of this medicine) • Your dosage regimen is (your doctor) • usually, over a period of about 30 seconds, and then slowly injected intravenously. • the time of inspection, it was injected at the time of the early morning hungry. Notes on life • that I am with the after care that is using this medicine (side effects) The main side effects, such as heat sensation, flushing with a focus on head and neck or face have been reported. If you notice these symptoms, please consult your doctor or pharmacist. In rare cases symptoms appear, such as the following, may be the initial symptoms of side effects indicated in brackets []. In such cases, discontinue use, please immediately seek medical care. • material is difficult to see, headache, vomiting [pituitary apoplexy] Other side effects not listed here may occur all. If you notice any symptoms of concern other than the above came out, please consult your doctor or pharmacist. Mitsubishi Tanabe Pharma Corporation injections  February 2014 revision  The medicine can have side effects as well as the effect (benefit) (risk). It is possible to suppress the side effects as much as possible, it is important to bring out the effect to the fullest. To do so, we must have the cooperation and understanding of patients who are using this medicine. http://www.kegg.jp/medicus-bin/japic_med?japic_code=00057352 https://www.c-notes.jp/medicines/7223406D1030/document