为人工合成HMG-CoA还原酶抑制剂，有明显的降低血清总胆固醇、LDL和血清TG的作用。与消胆胺配伍使用能使本品的降胆固醇作用增强。 口服后吸收迅速而完全。有肝脏首过效应，经胆汁排出，半衰期约为4-7小时。
若GOT或GPT持续超过正常上限3倍者，应中止治疗。有肝病及过量饮酒史者慎用。对伴有无法解释的弥漫性肌痛、肌肉触痛或肌无力以及肌酸磷酸激酶明显升高（超过正常上限10倍）的病人，应考虑肌病的可能性。病人被确诊或怀疑为肌病时，应停止治疗。严重肾功能不全病人不推荐应用本药。
药物相互作用
服用胆酸多价鳌合剂（考来烯胺）4hr后服用本药，表现出明显相加作用。本药应于服用离子交换树脂（如考来烯胺）后至少4hr进取。慎与免疫抑制剂、吉非贝齐、烟酸和红霉素合用。本药不影响安替比林的代谢和排泄。与利福平合用，本药的生物利用度降低约50％。
药品规格
Fluvastatin extended-release tablets
What are fluvastatin extended-release tablets?
FLUVASTATIN (Lescol® XL) blocks the body's ability to make cholesterol. Fluvastatin can help lower blood cholesterol for patients who are at risk of getting heart disease or a stroke. It is only for patients whose cholesterol level is not controlled by diet. It is not a cure. Generic fluvastatin extended-release tablets are not yet available.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
• an alcohol problem
• any hormone disorder (such as diabetes, under-active thyroid)
• blood salt imbalance
• infection
• kidney disease
• liver disease
• low blood pressure
• muscle disorder or condition
• recent surgery
• seizures (convulsions)
• severe injury
• an unusual or allergic reaction to fluvastatin, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding
How should I take this medicine?
Take fluvastatin tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. Take your doses at regular intervals. Do not take your medicine more often than directed.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
What drug(s) may interact with fluvastatin?
• alcohol
• cimetidine
• clopidogrel
• digoxin
• herbal medicines such as red yeast rice
• irbesartan
• medicines for treating fungal infections (fluconazole, voriconazole)
• medicines for treating HIV infections (delavirdine, efavirenz)
• medicines that suppress your immune response (cyclosporine)
• medicines to lower cholesterol or triglycerides (examples: cholestyramine, fenofibrate, gemfibrozil, niacin)
• omeprazole
• ranitidine
• rifampin, rifabutin, or rifapentine
• warfarin
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What should I watch for while taking fluvastatin?
Visit your prescriber or health care professional for regular checks on your progress. You will need to have regular tests to make sure your liver is working properly.
Tell your prescriber or health care professional as soon as you can if you get any unexplained muscle pain, tenderness, or weakness, especially if you also have a fever and tiredness.
Fluvastatin is only part of a total cholesterol-lowering program. Your physician or dietician can suggest a low-cholesterol and low-fat diet that will reduce your risk of getting heart and blood vessel disease. Avoid alcohol and smoking, and keep a proper exercise schedule.
If you are going to have surgery tell your prescriber or health care professional that you are taking fluvastatin.
This medicine should not be used by women who are pregnant or breast-feeding. There is a potential for serious side effects to an unborn child or to an infant. Talk to your health care professional or pharmacist for more information.
What side effects may I notice from taking fluvastatin?
Side effects that you should report to your prescriber or health care professional as soon as possible:
Rare or uncommon:
• dark yellow or brown urine
• decreased urination, difficulty passing urine
• fever
• muscle pain, tenderness, cramps, or weakness
• redness, blistering, peeling or loosening of the skin, including inside the mouth
• skin rash, itching
• unusual tiredness or weakness
• yellowing of the skin or eyes
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• diarrhea
• difficulty sleeping
• headache
• joint pain
• muscle soreness after exercise
• nausea, vomiting
• stomach upset or pain
Where can I keep my medicine?
Keep out of the reach of children in a container that small children cannot open.
Store at room temperature below 30 degrees C (86 degrees F). Keep container tightly closed. Protect from light. Throw away any unused medicine after the expiration date.
