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英文药名：CHOLEBINE Tablets（Colestimide，Colestilan）
中文药名：考来替兰片
生产厂家：田边三菱制药
给药说明
药品分类：高胆固醇血症的治疗剂
批准上市日期：1999年7月
商標名
CHOLEBINE 500mg Tablets
一般名
コレスチミド，Colestimide（JAN），Colestilan（INN）
化学名
2-Methylimidazole-epichlorohydrin copolymer
構造式
该产品具有复杂的构象熔融不规则但也表示产品[Ⅰ]的基本结构中，通过在部分[Ⅱ]所示的结构。
性状
是白色的粉末淡黄白色。
和在乙醇（99.5），或几乎不溶于水。
具有吸湿性。
适应症
高胆固醇血症，家族性高胆固醇
剂量与用法
成人，每日2次，每1次1.5克，给予水在早晨和傍晚。
然而，早晚餐后症状，服用的情况。该剂量应根据年龄和症状进行调整。
薬效薬理
1. 作用机序
Colestimide吸附胆汁酸在消化道中，由促尿酸尿的作用抑制胆汁酸肠肝循环，并提高分解代谢，从胆固醇胆汁酸在肝脏中。其结果，肝脏的胆固醇池被减小，因为这种补偿效应，提高的LDL在血液中的吸收是由于增加了肝LDL受体发生时，血清总胆固醇降低。此外，我还认为，胆固醇的吸收抑制胆汁酸胶束的形成抑制作用也有助于血清总胆固醇或吸附的直接外源性胆固醇的降低。
2. 胆固醇和胆汁酸吸收作用
Colestimide吸附在体外的各种胆汁酸。此外，吸附（胆酸，油酸，单油基甘油，磷脂，胆甾醇）和其组分对胆汁酸-脂质复合物的胶束。
3. 胆固醇和胆汁酸吸收抑制，，排泄促進作用
腹部淋巴管，门静脉血液中的总胆汁酸浓度总胆固醇显著经口给予大鼠降低。此外，显著增加粪便中胆固醇的排泄，粪便胆汁酸排泄显著有所增加，由Usagihe口服。
4. 对低密度脂蛋白受体
在肝脏中低密度脂蛋白受体mRNA的表达增加了Usagihe的口服给药。此外，LDL清除率分别提高了口服给药的仓鼠。
5. 降低血液中胆固醇的效
(1) 在兔和大鼠的动脉壁脂质沉积的抑制作用装载有胆固醇饮食，观察到血液中胆固醇的降低作用，并根据它的兔动作进行了观察。
(2) 在胆固醇饮食兔，对血中胆固醇降低作用的综合影响下观察该组合普伐他汀钠（HMG-CoA还原酶抑制剂）。
制造厂商
田边三菱制药株式会社
Cholebine Tablets 500mg
Mitsubishi Tanabe Pharma Corporation
Main component colestimide
Tablet dosage form of white
Sheet described Cholebine 500mg, CHOLEBINE500mg, MKC-141
The adsorption of cholesterol in the diet and bile acids in the digestive tract
• Effects of this medicine, it reduces the cholesterol levels.
I usually used in the treatment of familial hypercholesterolemia or hypercholesterolemia.
Please tell your doctor and pharmacist before you use experienced any of the following.
• there is that you use the medicine previously, allergic itch, rash etc.. Complete biliary obstruction, intestinal obstruction
• If you are pregnant or breastfeeding
• you are using the medicine to another (because there is a possibility that you can strengthen the effect on each other, or weakened, please note the drug being used in other, including the counter drugs).
• Normal regimen (proper use of this medicine) dose, for adults, take before dinner and before breakfast twice a day (1.5g of the active ingredient) 3 tablets once, but by the age and symptoms or disease being treated should be adjusted appropriately, the highest dose is 4g as a main component the 1st. Please follow the dosage instructions of always.
• When you left in the back of the throat and in the mouth, please plus drink more water.
• If you drink with warm water, because there is if you do not swallow it puffy, please drink cold water or in the water.
When it contains in the mouth a long time, because there is if you do not put drink puffy, please swallow immediately.
• If you forget to drink, please drink as soon as possible when it is noticed. However, if the time to drink the next close, please skip one minute and not drink the missed. This is not to drink at a time twice worth absolutely.
• Please consult your pharmacist or doctor if you took too much of this medicine by mistake.
Please do not quit without a physician's supervision, and a drink at the discretion of their own.
(Side effects) as the main side effect, has been reported constipation, abdominal bloating, nausea, and abdominal pain that I am careful after using this medicine. If you notice such symptoms, please consult your doctor or pharmacist.
There are initial symptoms of the adverse effects that symptoms such as the following rarely appeared, indicated in brackets.
In such a case, stop using it, please seek medical attention immediately.
[Intestinal perforation, intestinal obstruction] abdominal pain, nausea, stomach spring
Muscle pain in the limbs, numbness, weakness [rhabdomyolysis]
Or more side effects does not describe everything. If you notice any symptoms of concern other than those listed above appears, please consult your doctor or pharmacist.
• infants and other storage method, where it is not out of reach of children, please keep it away from direct sunlight, heat and moisture.
• If the drug is left, please discard it.
http://www.info.pmda.go.jp/go/pack/2189014D2024_2_03/
http://www.info.pmda.go.jp/go/pack/2189014D2024_2_05/2189014D2024_2_05?view=body#60
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产地国家: 日本
原产地英文商品名:
CHOLEBINE Tablets(コレバイン錠) 500mg/tab 100tabs/bottle
原产地英文药品名:
Colestimide，Colestilan
中文参考商品译名:
CHOLEBINE片(コレバイン錠) 100毫克/片 100片/盒（10錠×10）
中文参考药品译名:
考来替兰
生产厂家中文参考译名:
田边三菱制药
生产厂家英文名
Mitsubishi Tanabe Pharma
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产地国家: 日本
原产地英文商品名:
CHOLEBINE Tablets(コレバイン錠) 500mg/tab 500tabs/bottle
原产地英文药品名:
Colestimide，Colestilan
中文参考商品译名:
CHOLEBINE片(コレバイン錠) 100毫克/片 500片/盒（10錠×50）
中文参考药品译名:
考来替兰
生产厂家中文参考译名:
田边三菱制药
生产厂家英文名
Mitsubishi Tanabe Pharma
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