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英文药名：VICCILLIN-S COMBINATION TABLETS(Ampicillin Hydrate/Cloxacillin Sodium Hydrate)
中文药名：氨苄西林/氯唑西林钠复合片
生产厂家：明治药业
类别名称
复合青霉素类抗生素制剂
欧文商標名
VICCILLIN-S COMBINATION TABLETS
1.水合氨苄青霉素
性 状
氨苄西林水合物是白色结晶或结晶性粉末，以淡黄白色。
所述品微溶于水，微溶于甲醇中，非常微溶于乙醇（95）以及乙腈中几乎不溶。
一般名
アンピシリン水和物 Ampicillin Hydrate
略 号
ABPC
化学名
(2S,5R,6R)-6-［(2R)-2-Amino-2-phenylacetylamino］-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo［3.2.0］heptane-2-carboxylic acid trihydrate
分子式
C16H19N3O4S・3H2O
分子量
403.45
構造式
分配係数：（log10 1-オクタノール層／水層、20±5℃）
pH2.0：－2.7
pH4.0：≦－2.7
pH6.0：≦－3.0
2.氯唑西林钠水合物
性 状
氯唑西林钠水合物是白色结晶或结晶性粉末，以淡黄白色。
此产品是水，N，溶于N-二甲基甲酰胺或甲醇，微溶于乙醇（95）。
一般名
クロキサシリンナトリウム水和物
Cloxacillin Sodium Hydrate
略 号
MCIPC
化学名
Monosodium(2S,5R,6R)-6-｛［3-(2-chlorophenyl)-5-methylisoxazole-4-carbonyl］amino｝-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo［3.2.0］heptane-2-carboxylate monohydrate
分子式
C19H17ClN3NaO5S・H2O
分子量
475.88
構造式
分配係数：（log10 1-オクタノール層／水層、20±5℃）
pH2.0：≧2.3
pH4.0：0.91
pH6.0：－0.77
操作注意事项
由于被光渐渐褪色，要注意保存开盘后
适应症
氨苄青霉素/氯唑西林葡萄球菌，链球菌属，肺炎链球菌，肠球菌属的敏感性。，大肠杆菌，奇异变形杆菌，流感嗜血杆菌
<主治>
肺炎，肺脓肿，慢性呼吸道病变继发感染
剂量和给药方法
成人：每日口服一次：每次服250毫克-500毫克，每六小时。然而，这将增加或减少取决于患者的年龄和症状。
药效药理
体外抗菌作用
氨苄青霉素/氯唑西林表示对革兰氏阳性菌和革兰氏阴性菌的抗菌作用，它表现出抗微生物活性在多药耐药性金黄色葡萄球菌
包装规格
**250毫克（效价）作为包含在混合一片
PTP包装100片（10片×10片）
制造商（进口）
明治制果制药社
http://www.info.pmda.go.jp/go/pack/6191001F1036_1_03/6191001F1036_1_03?view=body#14
Brand name : VICCILLIN-S COMBINATION TABLETS
Active ingredient: Ampicillin hydrate
Cloxacillin sodium hydrate
Dosage form: light orange tablet, major axis: 13.2 mm, minor axis: 5.8 mm, thickness: 5.6 mm
Print on wrapping: ビクシリンS250mg, P-07, VICCILLIN-S250mg
Effects of this medicine
This medicine is a combination of penicillin antibiotics, which inhibit synthesis of the bacterial cell wall to exert a bactericidal antimicrobial effect.
It is usually used to treat pneumonia, lung abscess and infections secondary to chronic respiratory diseases.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have infectious mononucleosis.
If you, your parent(s) or sibling(s) is predisposed to allergy such as bronchial asthma, rash and hives.
If you have renal disorder.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•For adults: In general, take 1 or 2 tablets at a time, every 6 hours. The dosage may be adjusted according to the disease, age or symptoms. Strictly follow the instructions.
•If you miss a dose, take the missed dose as soon as possible. If there is less than 3 hours to the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
The most commonly reported adverse reactions include diarrhea, nausea, loss of appetite, fever, rash, hives and anemia. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•discomfort feeling, oral discomfort, dizziness [shock]
•fever, erythema with dropsical swelling in the center, bloodshot eyes [muco-cutaneo-ocular syndrome, toxic epidermal necrolysis]
•sore throat, muscle pain, anemia [agranulocytosis, hemolytic anemia]
•decreased urination output, swelling, headache [serious renal disorder such as acute renal failure]
•fever, frequent diarrhea, abdominal pain [serious colitis associated with bloody stool such as pseudomembranous colitis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them.
Meiji Seika Pharma Co., Ltd.Internal
Published: 9/2009
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
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