英文药名：ABILIFY OD tablets（Aripiprazole）

中文药名：阿立哌唑口腔崩解片

日文药名：エビリファイOD錠

生产厂家：大冢制药
药品介绍
阿立哌唑口腔崩解片是首个被称为“多巴胺系统稳定剂”的药品，它是一种由阿立哌唑和多巴胺结合产生作用用来治疗精神分裂症的处方药。
成人每日口服一次，开始的剂量是10毫克。用药两周之后，就可以根据个人的体制和病况逐渐增加剂量，但最大剂量是不能超过30毫克。此后就可以维持稳定的剂量不变。在使用时只需要保持手部的干燥，将药片放在舌面上，在数秒钟之中它就可以崩解。基本是不需要用水送药的，患者也不应该将药片分开或者是在嘴里咀嚼。
患心血管疾病如心肌梗塞、缺血性心脏病、心脏衰竭和患脑血管疾病的病患需要慎用。有癫痫病史的患者也需要慎用。同时，有吸入性肺炎风险性的也应慎用。而对其过敏的患者更是禁用此药。
同时，需要特别注意的是，在使用阿立哌唑口腔崩解片时，出现体位性低血压、癫痫发作、潜在的人质和运动损伤、体温的异常、吞咽困难、自杀、过度嗜睡等情况是比较常见的，要注意病患的情况，给予适当的护理。
通常来说，阿立哌唑口腔崩解片的治疗效果是相当不错的。患者在使用的过程中最好单独使用，不要同时使用多种药物，反而会降低药效，副作用也更多。
包装规格（エビリファイOD錠）
口腔崩解片：3mg
100片（10片×10），500片（10片×50）

口腔崩解片：6mg：
100片（10片×10），500片（10片×50）

口腔崩解片：12mg
100片（10片×10），500片（10片×50）

口腔崩解片：24mg
100片（10片×10），500片（10片×50）

生产商：大冢制药有限公司
Brand name : ABILIFY OD Tablets 3mg
　Active ingredient: Aripiprazole
　Dosage form: white tablet, diameter: 10 mm, thickness: 3 mm
　Print on wrapping: print on front of the sheet -エビリファイOD錠3mg
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Brand name : ABILIFY OD Tablets 6mg
　Active ingredient: Aripiprazole
　Dosage form: white tablet, diameter: approx. 12 mm, thickness: approx. 3 mm
　Print on wrapping: print on front of the sheet -エビリファイOD錠6mg
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Brand name : ABILIFY OD Tablets 12mg
　Active ingredient: Aripiprazole
　Dosage form: white tablet, diameter: approx. 14 mm, thickness: approx. 3 mm
　Print on wrapping: print on front of the sheet-エビリファイOD錠12mg
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Brand name : ABILIFY OD Tablets 24mg
　Active ingredient: Aripiprazole
　Dosage form: white tablet, diameter: approx. 18 mm, thickness: approx. 5 mm
　Print on wrapping: print on front sheet -エビリファイOD錠24mg
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Effects of this medicine
This medicine acts on receptors for dopamine, a neurotransmitter in the brain, to suppress symptoms such as hallucination and delusion and to stabilize unstable mental status. It also improves moods of lack of motivation and apathy, and symptoms such as unrestrained emotions and behaviors.
It is usually used in the treatment of schizophrenia and for improvement of manic episodes associated with bipolar disorder.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have diabetes or if you or your family has a history of diabetes.
If you have hepatic disorder, cardiovascular disease or hypotension.
If you have a convulsive disease such as epilepsy, or a history thereof.
If you have suicidal attempt or suicidal ideation.
If you have a predisposition to organic brain disorder.
If you have a highly impulsive comorbid disorder.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•For schizophrenia: In general, for adults, start with taking 6 to 12 mg of the active ingredient daily at one time or in two divided doses, then take 6 to 24 mg daily at one time or in two divided doses as the maintenance dose. The dosage may be adjusted according to age and symptoms. However, the daily dose should not exceed 30 mg of the active ingredient.
For improvement of manic episodes associated with bipolar disorder: In general, for adults, take 12 to 24 mg of the active ingredient at one time, once daily. The starting dose is determined as 1 tablet (24 mg of the active ingredient), and the dosage may be adjusted according to age and symptoms. However, the daily dose should not exceed 30 mg of the active ingredient.
This preparation contains 24 mg of the active ingredient in a tablet. In each case, strictly follow the instructions.
•You may take this medicine without water since the tablet melts once you put it in the mouth. Swallow it with saliva or water. Never take this medicine without water when you are in a lying position.
•Sometimes you may find the tablet is cracked or split when you take it out from the package, however, this will not affect its therapeutic effects. Take a whole tablet including the fragments.
•Peel off the sheet and take out the tablet from the package with dry hands immediately before taking it.
•If you miss a dose, take a dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•This medicine may cause sleepiness; decreased attentiveness, concentration and reflex movements. Avoid operating dangerous machinery such as driving a car.
•Alcohol may intensify the therapeutic effects of the medicine. Be careful when drinking alcohol.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include insomnia, nervousness, akathisia (restlessness), tremor (trembling of limbs), anxiety, weight loss, muscle rigidity, loss of appetite, somnolence, hypokinesia (expressionless face), salivation (drooling), weight gain, nausea, vomiting, dystonia (muscle tone abnormalities) and constipation. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•dry mouth, excessive intake of water, increased urine output  [diabetic ketoacidosis, diabetic coma]
•being silent without moving, muscle stiffness, sudden fever  [neuroleptic malignant syndrome]
•moving the tongue, putting tongue out and pull it back in, continual movement of the mouth appearing to chew something  [tardive dyskinesia]
•nausea, vomiting, constipation, intense abdominal pain  [paralytic ileus]
•weakness, muscle pain, reddish brown urine  [rhabdomyolysis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•This medicine should be stored in the package sheet without peeling off since it has hygroscopic property.
•Keep out of the reach of children. Store away from direct sunlight, heat and humidity.
•If there is a remainder, this is to be discarded. Do not store it. Ask the pharmacy or medical institution about how to discard the remainder.
Otsuka Pharmaceutical Co., Ltd.Internal
Published: 6/2013
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://www.info.pmda.go.jp/go/pack/1179045F4022_1_12/