英文药名：ABILIFY（Aripiprazole oral solution 0.1％）

中文药名：阿立哌唑口服液

生产厂家：大冢制药
类别名称
抗精神病药
欧文商標名
ABILIFY oral solution 0.1％
一般名：
アリピプラゾール〔Aripiprazole(JAN、INN)〕
化学名：
7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H )-quinolinone
構造式：

分子式：
C23H27Cl2N3O2
分子量：
448.39
性状：
它是一种白色结晶或结晶粉末。它是易溶于苄醇，乙酸（100）很容易微溶，水，乙腈，甲醇，和乙醇（99.5）实际上不溶，或己烷。
操作注意事项
它存储在一个地方让儿童接触不到的地方。
药理作用
本品是多巴胺和5-羟色胺系统的稳定剂，是突触后多巴胺受体的阻滞剂，同时又是突触前自主受体的激动剂，与D2和D3受体的亲和力非常强。本品是D2受体的部分激动剂，在活体多巴胺功能亢进模型中显示出较强的阻滞作用，而在多巴胺功能低下的模型中则表现出较强激动作用；本品能够抑制多巴胺激动剂引起的垂体前叶催乳素的升高，这种抑制作用可以被氟哌啶醇完全阻滞，因此，本品作用特点不是阻断而是稳定多巴胺系统的作用。同时本品又是5-HT1A受体的部分激动剂和5-HT2A受体的阻滞剂。从而发挥抗精神分裂症的焦虑、抑郁、认知缺损和阴性症状。本品能透过血-脑屏障，而且与D2受体的结合随剂量的增加而增加。
适应证
用于治疗精神分裂症，改善躁郁症（躁狂症状），抑郁症。 
用法用量
精神分裂症
成人第1次6〜12毫克（6〜12ml）中的起始剂量，每6天〜24mg（6〜24mL）的维持剂量，口服给药分为一次或两次。需要注意的是年龄，但根据症状调整，每日剂量不超过30毫克（30毫升）。
改善躁郁症
●躁狂症状
每日一次给予口服12〜24mg（12〜24mL），。此外，起始剂量和24mg（24mL），即年龄，将根据症状调整，每日剂量不应超过30毫克（30毫升）。
抑郁症
●（限于在那里没有观察到在现有的治疗充分的效果的情况下）
成人每天口服给药一次为3mg一包（3mL）。此外，年龄，和将根据症状调整，以每日剂量增大的宽度和3毫克（3mL）中，每日剂量不应超过15毫克（15毫升）。
包装规格
ABILIFY口服液0.1％：
3mL×28包(7包×4)

6mL×28包(7包×4)

12mL×28包(7包×4)

制造厂商
大冢制药有限公司

ABILIFY oral solution 0.1％（Aripiprazole）
Brand name : ABILIFY Oral Solution 0.1% (3mL-dose pack)
　Active ingredient: Aripiprazole
　Dosage form: colorless, clear liquid
　Print on wrapping: (face) エビリファイ内用液0.1%, 3mg/1包, 1mg/mL, (back) 3mg/1包, 3mL
-----------------------------------------
Brand name : ABILIFY Oral Solution 0.1% (6mL-dose pack)
　Active ingredient: Aripiprazole
　Dosage form: colorless, clear liquid
　Print on wrapping: (face) エビリファイ内用液0.1%, 6mg/1包, 1mg/mL, 6mL, (back) 6mg/1包, 6mL
-----------------------------------------
Brand name : ABILIFY Oral Solution 0.1% (12mL-dose pack)
　Active ingredient: Aripiprazole
　Dosage form: colorless, clear liquid
　Print on wrapping: (face) エビリファイ内用液0.1%, 12mg/1包, 1mg/mL, 12mL, (back) 12mg/1包, 12mL
-----------------------------------------
Effects of this medicine
This medicine acts on receptors for dopamine, a neurotransmitter in the brain, to suppress symptoms such as hallucination and delusion and to stabilize unstable mental status. It also improves moods of lack of motivation and apathy, and symptoms such as unrestrained emotions and behaviors.
It is usually used in the treatment of schizophrenia, for improvement of manic episodes associated with bipolar disorder and for depression/depressive state.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have diabetes or if you or your family has a history of diabetes.
If you have: hepatic disorder, cardiovascular disease or hypotension, convulsive disease such as epilepsy or a history thereof, suicidal attempt or suicidal ideation, a predisposition to organic brain disorder, a highly impulsive comorbid disorder.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•For schizophrenia: In general, for adults, start with taking 6 to 12 mL (6 to 12 mg of the active ingredient) daily, then take 6 to 24 mL (6 to 24 mg of the active ingredient) daily at one time or in two divided doses as a maintenance dose. The dosage may be adjusted according to age and symptoms. However, the daily dose should not exceed 30 mL (30 mg of the active ingredient).
For improvement of manic episodes associated with bipolar disorder: In general, for adults, take 12 to 24 mL (12 to 24 mg of the active ingredient) at one time, once daily. The starting dose is determined as 24 mL (24 mg of the active ingredient), and the dosage may be adjusted according to age and symptoms. However, the daily dose should not exceed 30 mL (30 mg of the active ingredient).
For depression/depressive state (administration should be limited to patients who showed an inadequate response to existing antidepressant therapy.): In general, for adults, take 3 mL (3 mg of the active ingredient) at one time, once daily. The dosage may be adjusted according to age and symptoms. The dose increase per day should be 3 mL (3 mg of the active ingredient). However, the daily dose should not exceed 15 mL (15 mg of the active ingredient).
This preparation contains 12 mL (12 mg of the active ingredient) in a sachet. In any case, strictly follow the instructions.
•You may take a dose of this medicine as it is or put it in a cup of (approx. 150 mL) warm water, cooled boiled water or juice and mix it, then take the mixture as soon as possible after dissolving. Never use unboiled water, beverages derived from tea leaves (black tea, oolong tea, green tea, brown rice tea, etc.) and bean paste soup (miso soup) to dissolve since the medicinal content may be reduced. In addition, when you mix this medicine with some water that has a high mineral content, sometimes you may find that the mixture is turbid. In this case, you should not take it since the medicinal content may be reduced.
•If you miss a dose, take a dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•This medicine may cause sleepiness; decreased attentiveness, concentration and reflex movements. Avoid operating dangerous machinery such as driving a car.
•Alcohol may intensify the therapeutic effects of the medicine. Be careful when drinking alcohol.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include insomnia, nervousness, akathisia (restlessness), tremor (trembling of limbs), anxiety, weight loss, muscle rigidity, loss of appetite, somnolence, hypokinesia (expressionless face), salivation (drooling), weight gain, nausea, vomiting, dystonia (muscle tone abnormalities) and constipation. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•dry mouth, excessive intake of water, increased urine output  [diabetic ketoacidosis, diabetic coma]
•being silent without moving, muscle stiffness, sudden fever  [neuroleptic malignant syndrome]
•moving the tongue, putting the tongue out and pulling it back in, continual movement of the mouth appearing to chew something [tardive dyskinesia]
•nausea, vomiting, constipation, intense abdominal pain  [paralytic ileus]
•weakness, muscle pain, reddish brown urine  [rhabdomyolysis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them. Ask the pharmacy or medical institution about how to discard the remainder.
Otsuka Pharmaceutical Co., Ltd.Internal
Revised: 5/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
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