英文药名: EpiQuin Micro(Hydroquinone Cream) 中文药名: 氢醌霜 药品简介 氢醌霜用于黄褐斑、雀斑、黑变病等色素沉着性皮肤病。 每晚用温水洗净患处，将药物适量涂于患处，并加以按摩，每日1次，6周为1疗程。由于氢醌是一种光感性物质，故适宜晚上使用，白天可配合使用一些防晒护肤霜。   EPIQUIN MICRO - hydroquinone cream  DPT Laboratories, Ltd. ---------- (hydroquinone USP 4%) Skin Lightening Moisturizing Topical Cream Rx only. FOR EXTERNAL USE ONLY. I. DESCRIPTION EpiQuin® Micro contains hydroquinone USP 4% and retinol (vitamin A) incorporated into patented porous microspheres (Microsponge®* System) composed of methyl methacrylate/glycol dimethacrylate crosspolymer. This polymeric system has been shown to provide gradual release of active ingredient into the skin.1 Hydroquinone is 1,4-benzenediol. Hydroquinone is structurally related to monobenzone. Hydroquinone occurs as fine, white needles. The drug is freely soluble in water and in alcohol and has a pKa of 9.96. Chemically, hydroquinone is designated as p-dihydroxybenzene; the empirical formula is C6H6O2; molecular weight 110.1. The structural formula is: ACTIVE INGREDIENT: Hydroquinone USP, 4% OTHER INGREDIENTS: Water, Caprylic/Capric Triglyceride, Emulsifying Wax, Dimethicone, Glycerin, C10-30 Cholesterol/Lanosterol Esters, Cetyl Alcohol, Cetyl Ricinoleate, Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer, Retinol (Vitamin A), Tocopheryl Acetate (Vitamin E), Ascorbic Acid (Vitamin C), Ascorbyl Palmitate, Bisabolol, Cyclomethicone, PEG-10 Soy Sterol, Polyacrylamide, C13-14 Isoparaffin, Laureth-7, Magnesium Aluminum Silicate, TEA-Stearate, Cetyl Phosphate, Butylated Hydroxy Toluene, Propyl Gallate, Disodium EDTA, Benzyl Alcohol, Methylparaben, Phenoxyethanol, Polysorbate 20, Triethanolamine, Sodium Metabisulfite. II. CLINICAL PHARMACOLOGY Topical application of hydroquinone produces a reversible depigmentation of the skin by inhibition of the enzymatic oxidation of tyrosine to 3-(3,4-dihydroxyphenyl)alanine(dopa) 2 and suppression of other melanocyte metabolic processes.3 Exposure to sunlight or ultraviolet light will cause repigmentation of the bleached areas.4 III. INDICATIONS AND USAGE EpiQuin® Micro is indicated for the gradual treatment of ultraviolet-induced dyschromia and discoloration resulting from the use of oral contraceptives, pregnancy, hormone replacement therapy, or skin trauma. IV. CONTRAINDICATIONS EpiQuin® Micro is contraindicated in any patient with a prior history of hypersensitivity or allergic reaction to hydroquinone or any of the other ingredients. The safety of topical hydroquinone use during pregnancy or on children (12 years and under) has not been established. V. WARNINGS A. CAUTION: Hydroquinone is a depigmenting agent which may produce unwanted cosmetic effects if not used as directed. The physician should be familiar with the contents of this insert before prescribing or dispensing this medication. B. Test for skin sensitivity before using EpiQuin® Micro by applying a small amount to an unbroken patch of skin and check within 24 hours. Minor redness is not a contraindication, but where there is itching, vesicle formation, or excessive inflammatory response, further treatment is not advised. Close patient supervision is recommended. Contact with the eyes should be avoided. If no lightening effect is noted after 2 months of treatment, use of EpiQuin® Micro should be discontinued. C. Sunscreen use is an essential aspect of hydroquinone therapy, because even minimal sunlight sustains melanocytic activity. To prevent repigmentation during treatment and maintenance therapy, sun exposure on treated skin should be avoided by application of a broad spectrum sunscreen (SPF 15 or greater) or by use of protective clothing. D. Keep this and all medications out of reach of children. In case of accidental ingestion, contact a physician or a poison control center immediately. E. WARNING: Contains sodium metabisulfite, a sulfite that may cause serious allergic reactions (e.g., hives, itching, wheezing, anaphylaxis, severe asthma attack) in certain susceptible persons. F. On rare occasions, a gradual blue-black darkening of the skin may occur, in which case, use of EpiQuin® Micro should be discontinued and a physician contacted immediately. VI. PRECAUTIONS (SEE WARNINGS): A. Pregnancy Category C: Animal reproduction studies have not been conducted with topical hydroquinone. It is also not known whether hydroquinone can cause fetal harm when used topically on a pregnant woman, or can affect reproductive capacity. It is not known to what degree, if any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used in pregnant women only when clearly indicated. B. Nursing mothers: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when hydroquinone is used by a nursing mother. C. Pediatric usage: Safety and effectiveness in pediatric patients below the age of 12 years have not been established. VII. ADVERSE REACTIONS No systemic reactions have been reported. Occasional cutaneous hypersensitivity (localized contact dermatitis) may occur, in which case the medication should be discontinued and the physician notified immediately. VIII. OVERDOSAGE There have been no systemic reactions reported from the use of topical hydroquinone. However, treatment should be limited to relatively small areas of the body at one time, since some patients experience a transient skin reddening and a mild burning sensation which does not preclude treatment. IX. DOSAGE AND ADMINISTRATION EpiQuin® Micro should be applied to the affected areas twice daily, morning and before bedtime, or as directed by a physician. Promptly tighten cap after each use. To prevent repigmentation during and after the use of EpiQuin® Micro, sun exposure should be limited and a sunscreen agent or sun-protective clothing should be used to cover the treated areas. There is no recommended dosage for pediatric patients under 12 years of age except under the advice and supervision of a physician. X. HOW SUPPLIED EpiQuin® Micro is supplied as follows: SIZE: 1 oz tube (30g) NDC NUMBER: 67402-010-30 Store at 25°C (77°F); excursions permitted to 15°-30°C (59°- 86°F) (see USP Controlled Room Temperature) EpiQuin Micro (hydroquinone USP 4%) Skin Lightening Moisturizing Cream Net Wt. 30 g