抗凝血酶Ⅲ副作用;别名:肝素辅因子、Heparin cofactor、AT-3;抗凝血酶Ⅲ适应症:用于治疗先天性或获得性(如肝硬化、肾病综合征、晚期肿瘤及败血症等)AT-Ⅲ缺乏所致的自发性深部静脉血栓形成或播散性血管内凝血(弥散性血管内凝血)。;抗凝血酶Ⅲ药理学作用:抗凝血酶Ⅲ是血液凝固过程中最重要的抑制物，为存在于血浆中的一种α2球蛋白，分子量为58000，由肝脏合成。正常人血浆中AFⅢ的浓度约为0.9U/ml，t1/2为2.7天。它与肝素结合后(克分子比例约为1：1)，其反应中心就极易与凝血酶及Ⅹa、Ⅸa、Ⅺa等凝血因子结合，生成不可逆的灭活复合物。当血浆中本品的活性减少至正常的50%以下时，肝素的抗凝作用就极弱。

分类名称
 
一级分类：血液系统药物 二级分类：抗凝血药 三级分类： 
 
药品英文名
 
Antithrombin Ⅲ
 
药品别名
 
肝素辅因子、Heparin cofactor、AT-3
 
药物剂型
 
注射剂(粉)：500U。
 
药理作用
 
抗凝血酶Ⅲ是血液凝固过程中最重要的抑制物，为存在于血浆中的一种α2球蛋白，分子量为58000，由肝脏合成。正常人血浆中AFⅢ的浓度约为0.9U/ml，t1/2为2.7天。它与肝素结合后(克分子比例约为1：1)，其反应中心就极易与凝血酶及Ⅹa、Ⅸa、Ⅺa等凝血因子结合，生成不可逆的灭活复合物。当血浆中本品的活性减少至正常的50%以下时，肝素的抗凝作用就极弱。
 
药动学
 
(尚不明确)
 
适应证
 
用于治疗先天性或获得性(如肝硬化、肾病综合征、晚期肿瘤及败血症等)AT-Ⅲ缺乏所致的自发性深部静脉血栓形成或播散性血管内凝血(弥散性血管内凝血)。
 
禁忌证
 
(尚不明确)
 
注意事项
 
用药前应测定血浆中AT-Ⅲ活性。
 
不良反应
 
目前尚未发现有严重不良反应。
 
用法用量
 
静脉输注：剂量随需要而定。给予AT-ⅢU/kg时，一般可提高活性的1.6%，但在弥散性血管内凝血患者仅提高1%。
 
药物相应作用
 
(尚不明确)

 
Antithrombin III Solution for injection

What is this medicine?

ANTITHROMBIN III (AN te throm bin) is a natural protein. It is used to treat patients with low levels of antithrombin III. People with this condition may have an increased risk for developing blood clots, especially during surgery or during pregnancy. This medicine may help to reduce the risk for blood clots or help to treat blood clots once they have already developed.
 
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
•an unusual or allergic reaction to antithrombin III, goat or goat milk proteins, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding

How should I use this medicine?

This medicine is for injection into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
•aspirin and aspirin-like drugs
•medicines that treat or prevent blood clots like warfarin or heparin
•mifepristone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Your condition will be closely monitored while you are receiving this medicine. Tell your doctor or health care professional if you experience any adverse effects while you are receiving this medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•chest tightness or chest pain
•itching or hot feeling around the injection site
•unusual bleeding or bruising like bleeding gums, red spots on the skin, nosebleeds, blood in the stool or urine
•unusually weak or tired
 
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•dizziness
 
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.