Lac-Hydrin含有的乳酸能帮助细胞再生，可用于身体肌肤干燥的护理，但现在，一些医生推荐将其用于脸部，因为它可以促进细胞的循环从而使肌肤光滑，不过使用初期会有轻微刺痛感。

若有红色的小突点可用2.5%-3%的Lac-Hydrin乳酸霜，能淡化斑点，美白。

Generic Name: ammonium lactate

Dosage Form: lotion

Lac-Hydrin Lotion Description

规格

LAC-HYDRIN TWELVE LOTION 400mls/bottle 、LAC-HYDRIN FIVE 5% LOTION 113mls/bottle 、LAC-HYDRIN 12% LOTION 225mls/bottle 、LAC-HYDRIN FIVE MOISTURIZING LOTION 8oz(226g)/bottle

*Lac-Hydrin specially formulates 12% lactic acid, neutralized with ammonium hydroxide, as ammonium lactate to provide a lotion pH of 4.5-5.5. Lac-Hydrin (ammonium lactate) Lotion, 12% also contains cetyl alcohol, fragrance, glycerin, glyceryl stearate, laureth-4, light mineral oil, magnesium aluminum silicate, methylcellulose, methyl- and propylparabens, PEG-100 stearate, polyoxyl 40 stearate, propylene glycol and water. Lactic acid is a racemic mixture of 2-hydroxypropanoic acid and has the following structural formula:

Lac-Hydrin Lotion - Clinical Pharmacology

Lactic acid is an alpha-hydroxy acid. It is a normal constituent of tissues and blood. The alpha-hydroxy acids (and their salts) are felt to act as humectants when applied to the skin. This property may influence hydration of the stratum corneum. In addition, lactic acid, when applied to the skin, may act to decrease corneocyte cohesion. The mechanism(s) by which this is accomplished is not yet known.

An in vitro study of percutaneous absorption of Lac-Hydrin Lotion using human cadaver skin indicates that approximately 5.8% of the material was absorbed after 68 hours.

Indications and Usage for Lac-Hydrin Lotion

Lac-Hydrin is indicated for the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris and for temporary relief of itching associated with these conditions.

Contraindications

Lac-Hydrin Lotion is contraindicated in those patients with a history of hypersensitivity to any of the label ingredients.

USES:

This medication is used to treat dry, scaly skin conditions (e.g., xerosis, ichthyosis vulgaris) and can also help relieve itching from these conditions. This medication works by increasing the moisture in the skin.

HOW TO USE:

If you are using the lotion, shake the bottle well before using.

Apply a thin layer of this medication to the affected areas of the skin, usually twice daily or as directed by your doctor. Rub the medication thoroughly into the skin.

Be careful to avoid your eyes, lips, inside your mouth/nose, the vaginal area, and any areas of broken skin. Stinging or burning may occur when this medication is applied on the face, on chapped skin, or on a recently shaved area of the skin. Consult your doctor or pharmacist for more details.

Inform your doctor if your skin condition does not improve or worsens.

Warnings

Sun exposure to areas of the skin treated with Lac-Hydrin (ammonium lactate) Lotion, 12% should be minimized or avoided (see PRECAUTIONS). The use of Lac-Hydrin Lotion should be discontinued if hypersensitivity is observed.

SIDE EFFECTS

The most frequent adverse experiences in patients with xerosis are transient stinging (1 in 30 patients), burning (1 in 30 patients), erythema (1 in 50 patients) and peeling (1 in 60 patients). Other adverse reactions which occur less frequently are irritation, eczema, petechiae, dryness and hyperpigmentation.

Due to the more severe initial skin conditions associated with ichthyosis, there was a higher incidence of transient stinging, burning and erythema (each occurring in 1 in 10 patients).

OVERDOSE

The oral administration of Lac-Hydrin (lactic acid) to rats and mice showed this drug to be practically non-toxic (LD50>15 mL/kg).

CLINICAL PHARMACOLOGY

Lactic acid is an alpha-hydroxy acid. It is a normal constituent of tissues and blood. The alpha-hydroxy acids (and their salts) may act as humectants when applied to the skin. This property may influence hydration of the stratum corneum. In addition, lactic acid, when applied to the skin, may act to decrease corneocyte cohesion. The mechanism(s) by which this is accomplished is not yet known.

An in vitro study of percutaneous absorption of Lac-Hydrin (lactic acid) Lotion using human cadaver skin indicates that approximately 5.8% of the material was absorbed after 68 hours.