英文药名: Actoplus Met(Pioglitazone/Metformin Tablets)
中文药名: 盐酸吡格列酮二甲双胍片
品牌药生产厂家: Takeda Pharmaceuticals
药物介绍
复方盐酸吡格列酮（pioglitazoneHC1）／盐酸二甲双胍（meforminHC1）片是日本武田制药株式会社研制开发的一种新型用于治疗Ⅱ型糖尿病的复方口服制剂。并于2005年8月获得FDA批准上市，商品名为ACTOplus。特别适用于辅助调节饮食和锻炼来控制血糖浓度的Ⅱ型糖尿病患者（联合用过吡格列酮与二甲双胍但单一用药不能控制）。
适应症
本品将两种广泛使用的糖尿病治疗药盐酸吡格列酮和盐酸二甲双胍制成单一片剂。盐酸吡格列酮直接作用于胰岛素耐受性，盐酸二甲双胍主要减少肝脏产生的葡萄糖量。两种药物结合有助于控制Ⅱ型糖尿病患者的血糖浓度。
用法用量
一日1次，或分剂服用，一日最大剂量不多于吡格列酮45mg和二甲双胍2550mg。（本品减少了患者原一日服用的药物的剂量，提高服药顺应性。）
任何疑问，请遵医嘱！
Active ingredient: metformin and pioglitazone.
Generic ActoPlus Met is used for treating type 2 diabetes.В It is used along with diet and exercise. It works by decreasing the amount of sugar the liver produces and the intestines absorb.
What is this medicine?
METFORMIN; PIOGLITAZONE helps to treat type 2 diabetes. It helps to control blood sugar. Treatment is combined with diet and exercise.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
become easily dehydrated
diabetic ketoacidosis
heart disease
if you frequently drink alcohol containing drinks
kidney disease
liver disease
polycystic ovary syndrome
serious infection or injury
swelling of the arms, legs, or feet
undergoing surgery or certain x-ray procedures with injectable contrast agents
vomiting
an unusual or allergic reaction to metformin, pioglitazone, medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I use this medicine?
Take this medicine by mouth with a glass of water. Take this medicine with food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor’s advice.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medicine?
Do not take this medicine with any of the following medications:
dofetilide
gatifloxacin
certain contrast medicines given before X-rays, CT scans, MRI, or other procedures
This medicine may also interact with the following medications:
atorvastatin
digoxin
diuretics
female hormones, like estrogens or progestins and birth control pills
gemfibrozil
insulin
isoniazid
ketoconazole
medicines for blood pressure, heart disease, irregular heart beat
midazolam
morphine
niacin
phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
phenytoin
procainamide
quinidine
quinine
ranitidine
rifampin
steroid medicines like prednisone or cortisone
thyroid hormones
trimethoprim
vancomycin
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular checks on your progress. Learn how to check your blood sugar. Tell your doctor or health care professional if your blood sugar is high, you might need to change the dose of your medicine.
If you are sick or exercising more than usual, you might need to change the dose of your medicine. Do not skip meals. Ask your doctor or health care professional if you should avoid alcohol.
If you have symptoms of low blood sugar, eat or drink something containing sugar at once and contact your doctor or health care professional.
Make sure family members know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, like seizures or unconsciousness. They must get medical help at once.
Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breathing problems
dark urine
dizziness
feeling faint or lightheaded, falls
fever, chills, sore throat
low blood sugar (ask your doctor or healthcare professional for a list of these symptoms)
muscle aches, pains
slow or irregular heartbeat
stomach pain
swelling of the hands, legs, or feet
unusually weak or tired
yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
diarrhea
headache
stomach gas, heartburn
nausea
problems with teeth
This list may not describe all possible side effects.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture and light. Throw away any unused medicine after the expiration date.