英文药名: Persantine(Dipyridamole)

中文药名: 潘生丁（双嘧达莫注射剂）

品牌药生产厂家: Boehringer Ingelheim

药品名称

通用名：双嘧达莫片（潘生丁）
别名: 哌醇定; 联嘧啶氨醇; 骈嘧哌胺醇; 潘散宁; 双嘧达莫; 双嘧哌胺醇; 骈嘧啶氨醇
英文名：Dipyridamole, Persantine
规格

25mg, 50mg, 75mg, 100mg
药理毒理

具有抗血栓形成作用。双嘧达莫抑制血小板聚集，高浓度（50 μg/ml）可抑制血小板释放。作用机制可能为⑴抑制红细胞摄取腺苷，而腺苷是一种血小板反应抑制剂；⑵抑制磷酸二酯酶，使血小板内环磷酸腺苷（cAMP）增多；⑶抑制血栓烷素A2（TXA2）形成，TXA2为血小板活性的强力激动剂；⑷增强内源性PGI2。双嘧达莫对血管有扩张作用。犬经十二指肠给予双嘧达莫0.5~4.0 mg/kg产生剂量相关性体循环和冠状血管阻力降低，体循环血压降低和冠脉血流增加。给药后24分钟起效，作用持续约3小时。静脉注射0.025~2.0 mg/kg后观察到类似效应。
药代动力学

口服吸收迅速，平均达峰浓度时间约75分钟，血浆半衰期为2～3小时。与血浆蛋白结合率高。在肝内代谢，与葡萄糖苷酸结合，从胆汁排泌。
适应症

对冠状动脉有较强的扩张作用，故临床上用于冠心病与阿斯司匹林合用预防急性心肌梗塞、预防一过性脑缺血，维持冠状动脉搭桥术的畅通。
用法用量

口服：１日３次，每次２５～５０ｍｇ，饭前１小时服。在症状改善后，可改为每日５０～１００ｍｇ，２次分服。
深部肌注：每次１０ｍｇ，６小时１次。
任何疑问，请遵医嘱！
注意事项

1.可有头痛、眩晕、恶心、呕吐、腹泻等不良反应。
2.不宜与葡萄糖以外的其他药物混合注射。
3.与肝素合用可引起出血倾向。
4.偶尔发生皮疹。

What is dipyridamole?

dipyridamole 5 mg/mL IVDrug Name: DIPYRIDAMOLE - INJ
Other Brand Names: Persantine IV
Uses: This medication is used to test the heart for blocked arteries and heart damage ("chemical" stress test). In a normal stress test, a patient exercises to make the heart beat faster. Dipyridamole may be used if you cannot safely exercise enough to make your heart beat faster. It causes the blood vessels in the heart to open. Diseased blood vessels do not open as well as healthy vessels, and this effect can be seen in images of the heart that are taken during the test.

Persantine (Dipyridamole)

Persantine
Generic name: Dipyridamole

Why is Persantine prescribed?

Persantine helps reduce the formation of blood clots in people who have had heart valve surgery. It is used in combination with blood thinners.

Some doctors also prescribe Persantine in combination with other drugs, such as aspirin, to reduce the damage from a heart attack and prevent a recurrence, to treat angina, and to prevent complications during heart bypass surgery.

Most important fact about Persantine

Persantine is sometimes used with aspirin to provide better protection against the formation of blood clots. However, the risk of bleeding may also be increased. To reduce this risk, take only the amount of aspirin prescribed by the same doctor who directed you to take Persantine. If you need a medication for pain or a fever, do not take extra aspirin without first consulting your doctor.

How should you take Persantine?

Persantine must be taken exactly as your doctor prescribes, at regularly scheduled times.

It is best to take Persantine on an empty stomach, with a full glass of water. However, if this upsets your stomach, you can take the drug with food or milk.

Do not change from one brand of dipyridamole to another without consulting your doctor or pharmacist. Products manufactured by different companies may not be equally effective.

If you miss a dose...
Take it as soon as you remember. If it is within 4 hours of your next scheduled dose, skip the dose you missed and go back to your regular schedule. Never take 2 doses at the same time.
Storage instructions...
Store at room temperature. Protect from excessive heat.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Persantine.

Side effects may include:
Abdominal distress, dizziness

Why should Persantine not be prescribed?

If you are sensitive to or have ever had an allergic reaction to Persantine or any of its ingredients, you should not use this medication. Make sure your doctor is aware of any drug reactions you have experienced.

Special warnings about Persantine

Use this medication carefully if you have low blood pressure.

Persantine has been known to cause liver problems, including liver failure. Contact your doctor immediately if you notice any of the following signs of liver trouble: nausea, fatigue, drowsiness, itching, yellowish skin, flu-like symptoms, and pain in the upper right abdomen.

Persantine should be used with caution if you have any heart problems, including angina or recent heart attack. Notify your doctor immediately if you experience any unusual chest pain.

Tell the doctor that you are taking Persantine if you have a medical emergency, and before you have surgery or dental treatment.

Possible food and drug interactions when taking Persantine

If Persantine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Persantine with the following:

Alzheimer's drugs

Aspirin

Blood thinners

Heart medications

Indomethacin

Ticlopidine

Valproic acid

Special information if you are pregnant or breastfeeding

The effects of Persantine during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. This drug appears in breast milk and may affect a nursing infant. If this medication is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with this medication is finished.

Recommended dosage for Persantine

ADULTS

The usual recommended dose is 75 milligrams to 100 milligrams, 4 times a day.

CHILDREN

The safety and effectiveness of this medication have not been established in children under 12 years of age.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose of Persantine, seek medical attention immediately.

Symptoms of Persantine overdose may include:
Dizziness, feeling of warmth, flushing, low blood pressure, rapid heartbeat, restlessness, sweating, weakness