NICERGOLINE

Product Information

Nicergoline (pronounced nice-er-go-lean) is perhaps the latest commercially available variation of all the ergot preparations. It has become most popular in Japan and indeed many of its clinical trials have been performed there.

Nicergoline appears to be a potent vasodilator (improving brain blood flow). On the cerebral level it prompts a lowering of vascular resistance, an increase in arterial flow and stimulates the use of oxygen and glucose. However, clinical trials confirm that nicergoline also improves blood circulation in the lungs and limbs and that blood platelet aggregation is inhibited.

Studies also indicate that nicergoline does not affect arterial tension and that in cases of patients suffering from hypertension, it may induce a gradual lowering of the tension.

The mechanism of Nicergoline is to increase vascular circulation in the brain and by enhancing the transmission of nerve signals across the nerve fibres, which secrete acetylcholine as a neural transmitter. According to the Manufacturer's insert, Sermion (nicergoline) has proved to be effective in hospital use, regulating and improving brain disorders caused by metabolic-vascular insufficiency and alterations derived from insufficient arterial irrigation in the limbs.

Do not take if you are pregnant or breast-feeding. May cause gastro-intestinal disturbances and hypotension. One study shows that Nicergoline enhances the cardiac depressant action of Propranolol.
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Detail info about the product:

Packing: 4 bottles 4 mg

Active Ingredients:

* Nicerogline

Therapeutic actions:

Nicergoline has alpha-adrenolytic action which activates the brain's metabolism and improves arterial flow, lowers vascular resistance and improves the use of glucose and oxygen. Furthermore, it is known that Nicergoline inhibits platelet aggregation. Studies have shown that Nicergoline also increases nerve growth factor in the aged brain.

Indications:

Nicerogline is used in the following cases:
* Acute and chronic cerebral metabolic-vascular disorders (cerebral arteriosclerosis, thrombosis and cerebral embolism, transitory cerebral ischaemia). Acute and chronic peripheral metabolic-vascular disorders (organic and functional arteriopathies of the limbs), Raynaud’s disease and other syndromes caused by altered peripheral irrigation.
* Migraines of vascular origin
* Coadjutant therapy in clinical situations accompanied by platelet hyper-aggregability, arterial tension.
* Corio-retinal vascular disorders: retinal thromboses, diabetic retinopathy, macular degeneration and retinal angiosclerosis
* Oto-vestibular problems of a vascular nature: dizziness, auditory hallucinations, hypoacusis.

Contraindications and cautions:

Persons suffering from acute bleeding, myocardial infarction (heart conditions), hypertension, bradycardia or using alpha or beta receptor agonists should consult with their physician before use.
Although toxicology studies have not shown nicergoline to have any teratogenic effect, the use of this medicine during pregnancy should be limited to those cases where it is absolutely necessary.

Adverse effects:

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Nicergoline can cause side effects they are usually limited to nausea, hot flushes, mild gastric upset, hypotension and dizziness. At high dosages bradycardia, increased appetite, agitation, diarrhea and perspiration have been known to present themselves.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

Interactions:

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.
Nicergoline is known to enhance the cardiac depressive effects of propranolol (Inderal®) - caution is advised. At high dosages, seek your physician's advice if combining with potent vasodilators such as Bromocriptine, Ginko Biloba, Hydergine, Picamilone, Vinpocetine or Xanthinol Nicotinate.

药品名称：注射用尼麦角林

作用与作用机制：

为半合成的麦角衍生物，具有α-受体阻断作用及血管扩张作用。能降低脑血管阻力，增加脑血流量，增加脑对氧和葡萄糖的利用。此外，尚有促进多巴胺的代谢，促进脑部蛋白质的合成，抑制血小板聚集和抗血栓等作用。

药动学：

口服能从胃肠道吸收，3-4.5h血药浓度达峰值。24h内60%从尿中排出。

注意事项：

主要为胃肠道反应。大剂量可出现低血压。本品可提高普萘洛尔的心脏抑制作用。应避免合用。

临床应用：

用于脑血管功能不全产生的行动不便与语言障碍等症状。能改善精神和情绪上的异常，提高学习、记忆能力，改善视力障碍、感觉迟钝等症状。也用于下肢闭塞性动脉内膜炎等外周血管疾病。

用法计量：

口服：10-20mg/次，3次/d。肌注、静注：2-4mg/次，1-2次/d，静滴时溶于100ml生理盐水中缓慢滴入。