【中文品名】美他多辛
【药效类别】酒精中毒治疗药
【通用药名】METADOXINE
【别　　名】Metadoxil
【化学名称】 L-Proline 5-oxo-, compd. with 5-hydroxy-6-methyl-3,4-pyridinedimethanol (1:1) 吡多醇吡咯烷酮羧酸盐
【CA登记号】[74536-44-0]
【结 构 式】

【分 子 式】CHNOPS·
【分 子 量】
【收录药典】
【开发单位】Baldacci
【首次上市】1985年，意大利
【性　　状】
【用　　途】5-羟色胺拮抗剂，用于治疗酒精中毒。

【药效分类】肝脏保护药

【规    格】 METADOXIL 300毫克/5毫升/安醅 10安醅/盒;METADOXIL 500毫克/片 30片/盒
1985年9月上市临床评价本品用于治疗急慢性醇中毒和醇性肝病。对急性醇中毒患者的激动、粗鲁放肆等症有明显疗效。本品起效快,耐受性良好。
主要用于治疗突慢性酒精性肝炎、对于急性酒精中毒的精神症状也有明显的治疗作用。本品可促进酒精在体内的清除速率,可使突性酒精中毒性肝炎病人血清酶指标降低较快,临床症状消失也较快,对酒精中毒伴发的激动、粗鲁放肆等精神症状亦有良好的治疗作用。对56例慢性中毒患者研究方表明,每天口服2克,共3个月,治疗期间不禁酒,治疗的第2月开始获良好效果,病人血清生化指标(γ-GT,胆红素,谷草转氨酶)出现明显的恢复。尽管继续饮酒,仍显示保肝作用。对患者的神经精神症状也有显著的改善作用。

Viboliv 500 (Metadoxine) - 500mg
Brand Name: Viboliv
Generic Name: Metadoxine
Form: Tablets
Manufacturer: Dr.Reddy's
Uses
Viboliv 500 (Metadoxine) is prescribed to patients who may have liver damage or fatty liver caused by either alcohol abuse or liver disease. It prevents further degeneration of the liver and therefore prevents more serious and possibly life threatening problems like hepatitis from occurring. It works by metabolizing the alcohol and other substances quicker and excreted them from the body faster.

Dosage and administration

Viboliv 500 (Metadoxine) should only be taken as prescribed. Correct dosage varies depending on the patient and on the severity of the condition being treated.

When used to treat liver damage caused by alcohol abuse the usual dosage is 500mg taken once a day. For chronic liver conditions such as liver disease or fatty liver, a common dosage is 500mg taken twice a day.

The maximum recommended dose for any 24 hours period is 1000mg.

Side effects

Viboliv 500 (Metadoxine) is usually well tolerated and any side effects are mild and short lasting. Side effects may still occur though, and your physician should be notified of any you notice. Pay special attention to your body so side effects can be picked up on early.

Seek medical attention immediately if you experience any skin rashes, diarrhea, hives, swelling, chest pains, trouble breathing, or difficulty swallowing.

Precautions

Viboliv 500 (Metadoxine) is not suitable for patients who are pregnant, trying to conceive, or breastfeeding.

Prior to using this medication disclose any of the following to your prescribing physician:

Any allergies you suffer from

Any existing medical condition you suffer from

Any other medication you are taking (including all non-prescription medicine)

Any vitamins, supplements, or herbal products which you are using
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What is Viboliv?
Viboliv is used to treat liver damage caused by fatty liver or liver disease caused by alcohol abuse. It is proven to prevent further deterioration, reducing the risks of serious liver conditions like hepatitis.? It also speed metabolism so unhealthy substances which put a strain on the liver are passed faster, causing less damage.

How is Viboliv used?
Patients using Viboliv to offset alcohol-related liver damage, are usually prescribed 500mg, twice a day. The maximum recommended dosage in any 24 hour period is 1000mg.

Adverse effects
Viboliv is usually very well tolerated by patients. Side effects normally experienced are very short-lasting and mild in severity, however you should always report any you notice to your health care provider.

Warnings
Immediately proceed to your nearest emergency department if you suffer an allergic reaction. Symptoms usually associated with such a reaction include difficulty breathing or swallowing, chest tightness, swelling, skin rashes, and hives.

Viboliv is not always suitable for all patients. Always consult your health care provider prior to using this medication if you are pregnant, breastfeeding, trying to conceive, using any other medication (prescription or non-prescription), using any herbal products or supplements, or if you have any allergies or other health problems.

The correct dosage and prescription commonly depend on the patient and the condition being treated. Do not adjust your dosage without the approval of your health care provider. This product is only for use as prescribed and instructed.
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原产地英文商品名:METADOXIL 500mg/5ml/amp 10amps/box

原产地英文药品名:METADOXINE

原产地英文化合物名称:L-Proline 5-oxo-, compd. with 5-hydroxy-6-methyl-3,4-pyridinedimethanol (1:1)

中文参考商品译名:METADOXIL 500毫克/5毫升/安醅 10安醅/盒