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部分中文Syntocinon处方资料（仅供参考）
缩宫素（Oxytocin）
【别名】催产素、Pitocin。
【作用和用途】
能直接兴奋子宫平滑肌，使子宫收缩。小剂量时，使妊娠末期子宫体产生节律性收缩，使子宫颈平滑肌松弛，促使胎儿顺利娩出。大剂量时引起子宫平滑肌的强直收缩，压迫肌纤维间血管而止血。
口服易被消化液所破坏，注射时作用迅速，但维持时间不长。
用于引产、催产、防治产后出血。
【剂量与用法】
引产和催产：静滴，2.5-5u/次，加入5%葡萄糖液500ml内缓慢滴注。
防治产后出血：肌注，5-10u/次，极量20u/次，也可加于5%葡萄糖中静滴。
【不良反应】
剖宫产术中宫体注射有致呼吸困难者。
过敏反应：表现为胸闷、憋气、寒战、发热、心慌、高热寒战（达41℃）、口周发绀、血压下降。
药物过量：剂量过大、滴速太快，可是子宫强直性收缩而致胎儿窒息、胎盘早期剥离或子宫破裂。
【注意事项】
骨盆过窄、产道受阻、明显头盆不称及横位产者禁用。
动脉粥样硬化者、心脏病、三胎以上产妇禁用。
有剖腹产史，子宫肌瘤剔除术史及臀位产者慎用。
【药物相互作用】
缩宫素与甲氧胺同用时，会引起血压升高及严重头痛
Syntocinon (oxytocin)
How does it work?
Syntocinon injection contains a synthetic version of the naturally-occurring hormone oxytocin. It works in the same way as the natural hormone.
Oxytocin is normally released by the pituitary gland in the brain towards the end of pregnancy to stimulate the smooth muscle of the uterus (womb). The oxytocin causes the muscle of the uterus to contract during labour so that the baby can be pushed out.
Synthetic oxytocin is used to induce labour for medical reasons, or if labour has not started naturally. The dose of the medicine is adjusted until the contractions produced are in a similar pattern to that of normal labour.
Synthetic oxytocin can also be used to stimulate labour that has started naturally, but is considered too weak to push out the baby. In this case the medicine strengthens the contractions of the uterus.
After the baby has been born, Syntocinon may be given to stimulate contractions that help push out the placenta and prevent heavy bleeding.
Syntocinon is given as a drip into a vein.
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What is it used for?
Starting (inducing) labour.
Stimulating labour when the contractions are considered too weak.
Preventing or controlling heavy bleeding following delivery of the child (post-partum haemorrhage).
During caesarian section following delivery of the child.
Management of certain types of miscarriage.
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Warning!
Syntocinon should not be started if you have been given a vaginal prostaglandin in the previous six hours.
The frequency, strength and length of contractions, as well as the baby's heartbeat, will all need to be monitored while you receive this medicine.
If high doses of this medicine are needed over a long period of time it may cause too much water to be retained in your body and the concentration of sodium in your blood to drop. Your doctor or midwife will take various measures to avoid this and may restrict the amount of fluid you can drink.
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Use with caution in
Women over 35 years of age.
Women with a small pelvis for whom vaginal delivery may be difficult.
Women who have previously had a caesarian section.
Heart disease.
High blood pressure caused by pregnancy (pre-eclampsia).
Situations when the womb begins to contract less strongly.
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Not to be used in
Women having unusually strong uterine contractions.
Cases where the baby is short of oxygen (foetal distress).
Cases where there is an obstruction that would prevent vaginal delivery.
Situations when inducing labour is inadvisable or vaginal delivery is not possible, for example, if the baby is in the wrong position, or if the woman has a low lying placenta (placenta praevia), a very small pelvis, or a scar on the womb from a previous caesarian section.
Syntocinon should not be used for prolonged periods if:
your contractions do not increase with the treatment
you have severe pre-eclamptic toxaemia (high blood pressure, protein in the urine and swelling)
you have severe problems with your heart or blood circulation.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
This medicine is widely used to start labour.
This medicine may pass into breast milk in small amounts, but will not have any harmful effect when you breastfeed your newborn baby, because it will be rapidly inactivated in the baby's gut.
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Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.
Common (affect between 1 in 10 and 1 in 100 people)
Headache.
Nausea and vomiting.
Slow or fast heartbeat.
Bleeding.
Uncommon (affect between 1 in 100 and 1 in 1000 people)
Irregular heartbeats (arrhythmias).
Rare (affect between 1 in 1000 and 1 in 10,000 people)
Skin rashes.
Allergic reaction associated with shortness of breath, low blood pressure (causing dizziness, lightheadedness, feeling faint) or shock (blood pressure too low to maintain blood supply to the tissues).
Increased risk of blood clots in the blood vessels following the birth of the baby.
Some women may experience spasm of the muscles of the womb at what would normally be considered low doses. A dose that is too high may cause very strong contractions of the womb that could result in tearing of the womb or tissue damage. It could also result in distress, suffocation or death of the baby.
If high doses of this medicine together with large amounts of fluid are given over long periods of time, water intoxication and low levels of sodium in the blood may occur. (Symptoms include headache, loss of appetite, nausea, vomiting, abdominal pain, lethargy, drowsiness, unconsciousness and seizures.)
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
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How can this medicine affect other medicines?
Your doctor or midwife will make sure that all medicines given during labour are compatible.
Prostaglandins increase the effect of oxytocin and vice-versa. Syntocinon should not be started if you have been given a vaginal prostaglandin in the previous six hours. If you are given oxytocin after a prostaglandin your contractions should be carefully monitored.
If oxytocin is given during or after an epidural it may enhance the blood pressure raising effect of medicines given to constrict the blood vessels.
Some inhaled anaesthetics used for general anaesthesia (cyclopropane or halothane) may reduce the effect of oxytocin. There may also be an increased risk of a drop in blood pressure and abnormal heart beats if oxytocin is given with these general anaesthetics.
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Other medicines containing the same active ingredient
There are currently no other medicines available in the UK that contain oxytocin alone.
Syntometrine contains oxytocin in combination with ergometrine.
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产地国家: 美国
原产地英文商品名:
Syntocinon 10iu/ml/vial 10vials/box
原产地英文药品名:
Oxytocin
中文参考商品译名:
Syntocinon 10IU/毫升/瓶 10瓶/盒
中文参考药品译名:
催产素
生产厂家中文参考译名:
诺华
生产厂家英文名:
Novartis
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