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部分中文LARPOSE处方资料（仅供参考）
【英文名称】Lorazepam
【中文名称】劳拉西泮; 7-氯-5-(2-氯苯基)-3-羟基-1,3-二氢-2H-1,4-苯二氮卓-2-酮,亦称为罗拉安定、氨羟安定、氨羟去甲安定。
口服容易吸收，达峰时间为2小时，半衰期为10－20小时。肌内注射吸收稳定，能够透过血脑屏障和胎盘屏障，也可分泌入乳汁，在肝脏代谢，代谢物由尿排出。
本品具有镇静催眠、抗焦虑、抗癫痫和止吐等作用。可用于治疗焦虑症和进行失眠和癫痫持续状态初期治疗。
不良反应轻，有镇静、眩晕、倦怠和共济失调等。老年人与肾功能不全者慎用。长期应用可产生依赖性。
【概述】
本药为短至中效苯二氮 类镇静催眠药，可引起中枢神经系统不同部位的抑制，随着用量的加大，临床表现可自轻度的镇静到催眠甚至昏迷。具有抗焦虑、镇静催眠作用、抗惊厥作用、骨骼肌松弛作用。
本药口服后1～6小时、肌肉注射1～1.5小时血药浓度达峰值，半衰期为10～20小时；血浆蛋白结合率高达85%；由肝脏代谢，经肾脏由尿液排泄。
【适应证】
（1）焦虑状态。
（2）失眠症。
（3）癫痫持续状态。
（4）癌症化疗时止吐（限注射剂）：有强的止吐作用，可与小剂量奋乃静合用。
（5）紧张性头痛。
（6）麻醉前及内镜检查前的辅助用药。
【应用原则】
（1）大剂量连续使用不应超过2周。
（2）静脉注射速度不超过2 mg/min。深部肌肉注射用于经口内窥镜检查前辅助用药，同时应进行局部麻醉以减少咽部反射性活动。
（3）服药期间不宜饮酒。
（4）吸烟者的使用剂量较不吸烟者要大。
【使用方法】
口服：抗焦虑，1次1～2 mg，1日2～3次。用于催眠，睡前服1～2 mg。
肌肉注射：抗焦虑、镇静催眠：按体重0.05 mg/kg，总量不超过4 mg。
静脉注射：用于癌症化疗止吐：在化疗前30分钟注射1～2 mg，与小剂量奋乃静合用效果更佳，必要时重复给药。静脉注射速度不超过2 mg/min。
【慎用及禁忌】
慎用：
（1）急性酒精中毒者。
（2）有药物滥用或成瘾史者。
（3）癫痫患者。
（4）肝肾功能损害者。
（5）ADHD患者。
（6）低蛋白血症患者。
（7）严重精神抑郁者。
（8）严重慢性阻塞性肺病患者。
（9）重症肌无力患者。
（10）老年患者。
（11）同时使用神经系统药物者，包括吩噻嗪类、巴比妥类、麻醉性镇痛药、抗抑郁药等。
禁用：
（1）对本药过敏者。
（2）急性闭角型青光眼患者、未治疗的开角型青光眼。
（3）睡眠呼吸暂停综合征患者。
（4）严重呼吸功能不全者。
（5）妊娠早期孕妇、小于6个月的儿童。
【不良反应】
（1）常见震颤、眩晕、虚弱、步态不稳。
（2）少见定向障碍、胃肠道症状、头痛和睡眠紊乱。
（3）儿童超量会出现幻视或幻听。
（4）静脉注射可导致静脉炎或静脉血栓形成。
（5）长期用药后突然停药偶可发生惊厥。
【注意事项】
（1）服药后24小时内不宜驾车和操纵机器。
（2）与镇痛药合用，可使血药浓度升高和过度嗜睡。
（3）在麻醉前给药可减少麻醉剂的剂量。
（4）可增强洛沙平、氯氮平的镇静作用，出现流涎和共济失调较多。
（5）与避孕药合用可降低其疗效。
（6）与乙胺嘧啶合用可能导致肝脏毒性。
Lorazepam Oral tablet
What is this medicine?
LORAZEPAM (lor A ze pam) is a benzodiazepine. It is used to treat anxiety.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
• alcohol or drug abuse problem
• bipolar disorder, depression, psychosis or other mental health condition
• glaucoma
• kidney or liver disease
• lung disease or breathing difficulties
• myasthenia gravis
• Parkinson's disease
• seizures or a history of seizures
• suicidal thoughts
• an unusual or allergic reaction to lorazepam, other benzodiazepines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. If it upsets your stomach, take it with food or milk. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on the advice of your doctor or health care professional.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What may interact with this medicine?
• barbiturate medicines for inducing sleep or treating seizures, like phenobarbital
• clozapine
• medicines for depression, mental problems or psychiatric disturbances
• medicines for sleep
• phenytoin
• probenecid
• theophylline
• valproic acid
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular checks on your progress. Your body may become dependent on this medicine, ask your doctor or health care professional if you still need to take it. However, if you have been taking this medicine regularly for some time, do not suddenly stop taking it. You must gradually reduce the dose or you may get severe side effects. Ask your doctor or health care professional for advice before increasing or decreasing the dose. Even after you stop taking this medicine it can still affect your body for several days.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To reduce the risk of dizzy and fainting spells, do not stand or sit up quickly, especially if you are an older patient. Alcohol may increase dizziness and drowsiness. Avoid alcoholic drinks.
Do not treat yourself for coughs, colds or allergies without asking your doctor or health care professional for advice. Some ingredients can increase possible side effects.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
• changes in vision
• confusion
• depression
• mood changes, excitability or aggressive behavior
• movement difficulty, staggering or jerky movements
• muscle cramps
• restlessness
• weakness or tiredness
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
• constipation or diarrhea
• difficulty sleeping, nightmares
• dizziness, drowsiness
• headache
• nausea, vomiting
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of the reach of children. This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date.
附件：
201082223081816.pdf
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原产地英文商品名:
LARPOSE(ATIVAN EQUIVALENT) 1mg/tab 100tabs/box
原产地英文药品名:
Lorazepam
中文参考商品译名:
LARPOSE(ATIVAN仿制药) 1毫克/片 100片/盒
中文参考药品译名:
劳拉西泮
中文参考化合物名称:
7-氯-5-(2-氯苯基)-3-羟基-1,3-二氢-2H-1,4-苯二氮卓-2-酮
生产厂家中文参考译名:
CIPLA
生产厂家英文名:
CIPLA
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