英文药名: Humatin(Paromycin Sulfate Capsules)
中文药名: 巴龙霉素胶囊
生产厂家: Erfa
分类名称
一级分类：抗生素 二级分类：氨基糖苷类 三级分类：
药品英文名
Paromomycin
药品别名
巴母霉素、巴罗姆霉素、Monomycin Humatin
药物剂型
胶囊剂：250mg
药理作用
本药属于氨基糖苷类抗生素，不仅有抑制大肠菌群间接产生抗阿米巴作用，而且还具有直接杀灭阿米巴滋养体的作用。尚有驱绦虫作用。
药动学
在胃肠很少被吸收，大部分自粪便排出。
适应证
用于急性阿米巴痢疾，对慢性患者多无效，对肠外阿米巴病无效。也可用于治疗绦虫病。
禁忌证
对本品过敏者禁用。肾功能不全及对巴龙霉素过敏者禁用。
注意事项
长期口服可能引起听力损害；长期应用可引起吸收不良综合征。肌注毒性反应很强，可造成肾及听神经的损伤，不宜用于注射。肝、肾功能不良、肠道溃疡、孕妇、老年人及听力下降者慎用。
不良反应
偶有胃肠不适、腹泻、少数病人有皮疹，如果长期应用，可引起吸收不良综合征及二重感染，注射给药可损伤听力和肾脏。
用法用量
成人：
1.治疗阿米巴痢疾及肠道细菌感染，口服，1次0.5～0.75g，4次/d，连服5～10天。
2.治疗绦虫病，每天按75mg/kg，顿服，每次剂量不超过4g，5天为一疗程。小儿：治疗阿米巴痢疾，每天按30～50mg/kg，其他同成人。
HUMATIN - paromomycin sulfate capsule
Monarch Pharmaceuticals, Inc
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Description
Humatin is a broad spectrum antibiotic produced by Streptomyces rimosus var. paromomycinus . It is a white, amorphous, stable, water-soluble product supplied as capsules containing the equivalent of 250 mg paromomycin.
The capsule contains D&C yellow No. 10; FD&C blue No. 1; FD&C red No. 3; FD&C yellow No. 6; gelatin, NF; and titanium dioxide, USP.
Action
The in vitro and in vivo antibacterial action of paromomycin closely parallels that of neomycin. It is poorly absorbed after oral administration, with almost 100% of the drug recoverable in the stool.
Indications
Humatin is indicated for intestinal amebiasis––acute and chronic (NOTE ––It is not effective in extraintestinal amebiasis); management of hepatic coma––as adjunctive therapy.
Contraindications
Paromomycin sulfate is contraindicated in individuals with a history of previous hypersensitivity reactions to it. It is also contraindicated in intestinal obstruction.
Precautions
The use of this antibiotic, as with other antibiotics, may result in an overgrowth of nonsusceptible organisms, including fungi. Constant observation of the patient is essential. If new infections caused by nonsusceptible organisms appear during therapy, appropriate measures should be taken.
The drug should be used with caution in individuals with ulcerative lesions of the bowel to avoid renal toxicity through inadvertent absorption.
Pediatric Use: See Dosage and Administration section.
Adverse Reactions
Nausea, abdominal cramps, and diarrhea have been reported in patients on doses over 3 g daily.
Dosage and Administration
Intestinal amebiasis: Adults and Pediatric Patients: Usual dose––25 to 35 mg/kg body weight daily, administered in three doses with meals, for five to ten days.
Management of hepatic coma: Adults: Usual dose––4 g daily in divided doses, given at regular intervals for five to six days.
How Supplied
Humatin Capsules, each containing paromomycin sulfate equivalent to 250 mg paromomycin, are supplied as follows
NDC 61570-529-10: Bottles of 100
Store at controlled room temperature 15°–30°C (59°–86°F).
包装规格
250mg *100 胶囊 /瓶