英文药名：Cefzon Fine Granules 10% for Pediatric（Cefdinir） 中文药名：头孢地尼儿科细颗粒10％ 生产厂家：安斯泰来制药 セフゾン細粒小児用10％ 治疗类别名称 口服头孢菌素制剂 批准上市日期：1993年6月 商標名 Cefzon Fine Granules 10％ for Pediatric 一般名 セフジニル（Cefdinir） 略号 CFDN 化学名 (6R,7R )-7-[(Z )-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetylamino]-8-oxo-3-vinyl-5-thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid 構造式 分子式 C14H13N5O5S2 分子量 395.41 融点 淡黄色从150℃附近，然后逐渐增加的棕色，分解变成黑色在220℃附近。 分配係数 4.0×10-2（1-オクタノール／水系） 性状 头孢地尼是白色的结晶粉末至浅黄色。水，乙醇（95）或在乙醚中几乎不溶。可溶于pH值7.0的0.1mol/L的磷酸盐缓冲液。 操作注意事项 避光，保存，避免受潮。[怕有凝固因衰落和水分因光线] 药效药理 1.抗菌作用 (1) 革兰氏阳性菌和阴性菌，尤其是革兰氏阳性菌的金黄色葡萄球菌的广泛的抗菌谱，显示了对链球菌属等很强的抗菌活性，效果杀菌。 (2) 稳定对β-内酰胺酶来生产各种类型的细菌，它示出了抗菌活性也优于β-内酰胺酶生产菌。 2.作用机制 作用机制是细菌细胞壁的合成的抑制，动作可以根据细菌种类，青霉素结合蛋白（PBP）（1α，1BS）的不同而不同的点，具有对2和3具有高亲和性。 适应病症 金黄色葡萄球菌的代理感性，链球菌属，肺炎链球菌，莫拉（布兰汉）卡他莫拉菌，大肠杆菌，克雷伯氏菌，变形杆菌，流感嗜血杆菌 浅表皮肤感染，深层皮肤感染，淋巴管，淋巴结炎，慢性脓皮病，咽炎，喉炎，扁桃体炎，急性支气管炎，肺炎，膀胱炎，肾盂肾炎，中耳炎，鼻窦火焰，猩红热。 用法与用量 正常，口服分为每天服用9-18毫克（效价）/kg的三倍，对儿童的头孢地尼。 用量应适当地根据年龄和状况进行调整。 包装规格 100g 200g 0.5g×120包 制造商 安斯泰来制药公司 原研药品资料附件：http://www.info.pmda.go.jp/go/pack/6132013C1031_3_06/ 头孢地尼(Cefdinir)细粒 【别　　名】Cefzon, Cefzon fine granules, Cl-983, FK-482, Omnicef 【开发单位】藤泽 【首次上市】1991年，日本 头孢地尼(cefdinir) 属第3代头孢。日本藤泽药品工业公司原研，1991年首次在日本上市，商品名Cefzon，1997年12月被美国上市，1999年在韩国上市。 本品是第三代广谱头孢菌素，为高效口服头孢菌素，对需氧和厌氧革兰阳性菌和阴性菌均有强广谱抗菌活性，对多种β-内酰胺酶稳定。对葡萄球菌、链球菌及丙酸杆菌的抗菌活性特别强。临床主要用于葡萄球菌、链球菌、丙酸杆菌、淋球菌、大肠杆菌、克雷白菌、奇异变形杆菌、流感杆菌、普鲁威登斯菌等引起的感染，如咽喉炎、扁桃腺炎、支气管炎、肺炎、肾盂肾炎、膀胱炎，淋菌性尿道炎及妇科、外科、皮肤、软组织染等。剂量，口服，成人100mg/次，3次/日。副作用有胃肠道反应、腹泻及软便，偶见过敏反应如皮疹、瘙痒、丙氨酸氨基转移酶升高。对青霉素过敏者及过敏体质者慎用。 Cefzon fine grains for children 10% Product name Cefzon fine grains for children 10% Main ingredient Cefdinir Classification name - Dosage form Pale red white fine granules Pharmaceutical company Astellas Pharma Inc. efficacy It inhibits proliferation by inhibiting bacterial cell wall synthesis and shows antibacterial action. It is a cephem antibiotic used to treat infectious diseases. It is usually used for the treatment of a wide range of infectious diseases such as respiratory infections, skin infections, otorrhoea infections and urinary tract infections. Usage notes I have used all medicine before and it has been allergic symptoms such as itching and rash. Pregnant or lactating We are using other medicines (we may strengthen or weaken each other 's actions, so please be careful including other general - use medicines and foods in use). Dosage regimen Usually, children will take 0.03 to 0.06 g / kg (3 to 6 mg / kg (titer) as the main component) once a day three times a day. It will be increased or decreased according to the disease to be treated, age and symptoms as appropriate. This product contains 100 mg (potency) as the main component in 1 g. Please follow the directions given by your doctor. In case you forget to drink, when you are aware, please drink as much as possible as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Never drink 2 doses at once. Please consult your doctor or pharmacist if you drink too much accidentally. Please do not stop drinking at your own discretion without your doctor's instructions. Living attention When combined with iron added products such as powdered milk and enteral nutrients, flights may become red. Urine may become red. Side effect There are reports of rash, urticaria, erythema, edema, itching, fever, diarrhea, abdominal pain, etc. as main side effects. If you notice such symptoms, please consult your doctor or pharmacist. The following symptoms appear rarely and there is a possibility that it is the initial symptom of side effects shown in []. In such cases, please stop using and get medical attention immediately. Discomfort, mouth abnormal feeling, dyspnea [shock, anaphylactoid symptoms] Fever, blisters, red rash [skin mucosal ocular syndrome, toxic epidermal necrosis] Fever, petechiae, anemia symptoms [pancytopenia, agranulocytosis, thrombocytopenia, hemolytic anemia] Fever, coughing from, dyspnea [interstitial pneumonia, PIE syndrome] General malaise, anorexia, yellowing of skin and whites [fulminant hepatitis, liver dysfunction, jaundice] These side effects do not describe everything. Please consult your doctor or pharmacist if any other symptoms other than the above are noted. Storage method Other Keep out of the reach of children, away from light, high temperature and moisture. If medicine remains, please discard it without storing it.