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当前位置:药品说明书与价格首页 >> 精神心理 >> 精神分裂症 >> 药品推荐 >> Orap Tablets/Fine Granules 1%(匹莫齐特片/颗粒)

Orap Tablets/Fine Granules 1%(匹莫齐特片/颗粒)

2016-10-10 11:51:11  作者:新特药房  来源:互联网  浏览次数:13  文字大小:【】【】【
简介: 英文药名:Orap Tablets/Fine Granules 1%(Pimozide) 中文药名:匹莫齐特片/颗粒1% 生产厂家:安斯泰来制药 オーラップ錠1mg/オーラップ錠3mg/オーラップ細粒1% 药品介绍商標名 Orap Tablets ...

英文药名:Orap Tablets/Fine Granules 1%(Pimozide)

中文药名:匹莫齐特片/颗粒1%

生产厂家:安斯泰来制药

オーラップ錠1mg/オーラップ錠3mg/オーラップ細粒1%

药品介绍
商標名
Orap Tablets 1mg
Orap Tablets 3mg
Orap Fine Granules 1% 
一般名
ピモジド(Pimozide)
化学名
1-{1-[4,4-Bis(4-fluorophenyl)butyl]piperidin-4-yl}-1,3-dihydro-2H -benzimidazol-2-one
構造式

分子式
C28H29F2N3O
分子量
461.55
融点
216~220℃
性状
匹莫齐特是淡黄白色粉末白色。易溶于乙酸(100),微溶于甲醇或乙醇(99.5),并且几乎不溶于水。
药效药理
1. 匹莫齐特作为特定于神经安定剂的药理作用,大鼠,强条件反射抑制对狗或猴,抗阿朴吗啡作用,抗苯丙胺作用的效果,示出木僵诱导作用等,这些影响比氯丙嗪明显强,氟哌啶醇等于或稍强。虽然相对于氯丙嗪和氟哌啶醇匹莫齐特的动作比较慢的表达,它显然不再持续。
2. 匹莫齐特麻醉增强小鼠的行为,体温,降低大鼠效果比氯丙嗪和氟哌啶醇,同时,弱对抗乙酰胆碱弱得多,组胺和肾上腺素的外围设备。
3. 匹莫齐特不是对大脑多巴胺和去甲肾上腺素的浓度在大鼠中减少大量的明显的影响。
此外,选择性阻断大脑多巴胺受体,但是可以提高成交率,在去甲肾上腺素系统,只有提高成交率,而不阻断其受体。
4. 匹莫齐特是无为而治,自闭症,以及改善患者的症状,如接触电阻和沟通障碍,自发性增强,积极参与的工作,合适的效果,唤起社会的目的,比如把促进工作效率获得。
此外,以恒定的心理活动水平的维持,也可观察到的症状的稳定作用。另一方面,弱催眠镇静剂,自主神经系统的更少的操作。
适应病症
精神分裂症
儿童自闭症,智力低下有关的下列症状
运动,情感,动机,在人际交往看到异常行为等。
睡眠,饮食,排泄,在语言或类似症状。
精神病症状sterotypy等。
用法用量
精神分裂症
成年人:每天一次以下量,如果有必要分成2-3次,口服给药。
初始将根据1-3毫克,症状逐渐提高到4-6毫克。最高可达9毫克。维持剂量通常为6mg以下。
用量应酌情取决于条件进行调整。每天一次。
儿童自闭症,智力低下有关的下列症状
运动,情感,动机,在人际交往看到异常行为等。
睡眠,饮食,排泄,在语言或类似症状。
精神病症状sterotypy等。
典型的小儿,每天服用1-3毫克1每日一次口服。年龄,根据症状进行调整,但可增至的每日剂量为6mg,它可任选也有分开的剂量,每日两次。
此外,提供了适合的清除期的给药所获得的稳定的状态,以确定随后的给药是否继续。
包装规格
片剂
1毫克:100片(10片×10)
3毫克:100片(10片×10)
細粒1%
100g
制造和销售
安斯泰来制药公司
完整处方资料附件:http://www.info.pmda.go.jp/go/pack/1179022C1034_1_10/
Orap Tablets/Fine Granules 1%(Pimozide)
Orap Tablets 1mg(オーラップ錠1mg)
Brand name : Orap Tablets 1mg
 Active ingredient: Pimozide
 Dosage form: pink tablet (φ: 6.5mm, thickness: 2.7mm)
 Print on wrapping: (Face) オーラップ1mg, f111, house-mark, (Back) オーラップ, f111, 1mg, ピモジド(Pimozide), house-mark
Orap Tablets 3mg(オーラップ錠3mg)
Brand name : Orap Tablets 3mg
 Active ingredient: Pimozide
 Dosage form: white tablet (φ: 6.5mm, thickness: 2.7mm)
 Print on wrapping: (Face) オーラップ3mg, f131, house-mark, (Back) オーラップ, f131, 3mg, ピモジド(Pimozide), house-mark
Orap Fine Granules 1%(オーラップ細粒1%) 
Brand name : Orap Fine Granules 1%
 Active ingredient: Pimozide
 Dosage form: white fine granules
 Print on wrapping: 
Effects of this medicine
This medicine acts on a transmitter in the brain (dopamine) and improves such symptoms as severe anxiety or tension, and lowering of motivation.
It is usually used for the treatment of abnormal behavior, pathological symptoms, psychological symptoms, etc. associated with children's autistic disorder or intellectual disability, and also for stabilization of the mental state.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you have a current, past or family history of arrhythmia.
If you have become comatose.
If you have depression.
If you are a patient with Parkinson's disease.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•General dosage regimen:
For children with symptoms associated with autistic disorder or intellectual disability: Take 1 to 3 tablet/s (1 to 3mg of the active ingredient) at a time, once daily. The dosage may be adjusted according to the patent's age and symptoms, and the daily dose may be increased up to a maximum of 6 tablets (6mg) that may be taken in two divided portions per day.
For other conditions than the above: For adults, take 1 to 3 tablet/s (1 to 3mg of the active ingredient) per day, once daily. The daily dose may be taken in 2 to 3 divided portions when necessary. The daily dose may be gradually increased to 4 to 6 tablets (4 to 6mg) according to the symptoms. The maximum daily dose should not exceed 9 tablets (9mg), and, in general, the maximum maintenance daily dose should not exceed 6 tablets (6mg). The dosage may be adjusted according to the patient's symptoms. Take the medicine in the morning as much as possible, if it is taken once daily.
In either case, strictly follow the instructions of your doctor/pharmacist.
•If you have missed a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take double doses to make up for the missed dose.
•If you took too much of the medicine (more than ordered), check with your doctor/pharmacist.
•Do not stop taking the medicine without the instructions of your doctor.
Precautions while taking this medicine
•Taking this medicine may cause sleepiness, dizziness or a swaying feeling. Do not operate dangerous machinery such as driving a car.
•Intake of alcohol may enhance the effect of this medicine. Refrain from drinking alcohol while taking the medicine.
•Intake of grapefruit or grapefruit juice may enhance the effect of this medicine. Do not consume these at the same time as taking the medicine.
Possible adverse reactions to this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: sleep disorder (loss of sleep, sleepiness), tremor (trembling of the hands and legs), akathisia (inability to sit still), salivation (drooling), rash, itching, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•palpitations, discomfort of the chest  [ventricular tachycardia, sudden death]
•spiking fever, tremor of the hands and legs, stiffness of muscle  [neuroleptic malignant syndrome]
•spasms or cramps  [convulsive seizures]
•loss of appetite, queasiness/vomiting, spasms or cramps  [hyponatraemia]
•throat pain, headache, fever  [agranulocytosis, decreased white blood cells]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of infants and children. Store away from direct sunlight, heat and humidity.
•Discard the remainder. Do not store them. Consult with your dispensing pharmacy when you discard the medicine.

责任编辑:admin


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