| Part of the Chinese ampicillin sulbactam prescribing information (for reference only) Common name Ampicillin sulbactam sodium for injection Pharmacology and Toxicology Ampicillin is a penicillin antibiotic. Sulbactam semi-synthetic (lactamase inhibitors, Neisseria gonorrhoeae, Neisseria meningitidis and calcium acetate Acinetobacter has strong antibacterial activity, the role of other bacteria are very poor, but the golden yellow staphylococci and most gram-negative bacteria generated (lactamase has a strong competitive irreversible inhibition. combination of two drugs, not only to protect against ampicillin hydrolase destruction, but also to expand its antimicrobial spectrum, producing strains of Staphylococcus, Acinetobacter and Bacteroides fragilis and other bacteria with good antibacterial activity. including the product of enzyme production strains, including Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus, Haemophilus influenzae bacteria, Moraxella catarrhalis, Escherichia coli, Klebsiella, Proteus mirabilis, Proteus vulgaris, Neisseria gonorrhoeae, Fusobacterium, Peptococcus genus Peptostreptococcus and including Bacteroides fragilis in both within the genus Bacteroides with antibacterial activity. Pharmacokinetic Intravenous ampicillin and sulbactam 1g 2g after peak plasma concentration (Cmax) was 109 ~ 150mg / L and 44 ~ 88mg / L. 1g intramuscular injection of ampicillin and sulbactam after peak plasma concentration 0.5g (Cmax) was 8 ~ 37mg / L and 6 ~ 24mg / L. Blood elimination half-life of two drugs (t1 / 2 () are about 1 hour. Between 8 hours after administration of about 75% to 85% excreted unchanged in the urine. Ampicillin protein binding rate of 28% for the SBT 38% of both good distribution in tissue fluids, and can be accessed through inflammation of the brain and spinal cord membranes. Indications This applies to goods produced (lactamase Haemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae, Staphylococcus, Escherichia coli, Klebsiella, Proteus mirabilis, Bacteroides fragilis, not Acinetobacter spp, Enterococcus, etc. due to the respiratory tract, hepatobiliary system, urinary tract, skin and soft tissue infections, mixed aerobic and anaerobic infections, particularly intra-abdominal infections and pelvic infections is particularly applicable. ampicillin-susceptible strains for these infections caused by equally effective. This product is not for Pseudomonas aeruginosa, Citrobacter, general Vuitton bacteria, Enterobacter, and Serratia spp Morgan infection caused. Dosage Deep intramuscular injection, intravenous injection or intravenous drip. The amount of each drug was dissolved in 50 ~ 100ml appropriate diluent for intravenous infusion over 15 to 30 minutes. An adult 1.5 ~ 3g (including ampicillin and sulbactam) every 6 hours. Intramuscular injection daily dose does not exceed 6g, intravenous drug daily dose does not exceed 12g (SBT does not exceed the maximum daily dose 4g). Children's body weight day 100 ~ 200mg/kg, in divided doses. Adverse reactions 11,764 cases, according to U.S. and European data, the occurrence of adverse reactions were less than 10%, of which only 0.7% due to severe adverse reactions to stop treatment. Approximately 3.6% of injection site pain, diarrhea, nausea and other reactions occasionally occur, rash incidence of 1% to 6%. Serum aminotransferase occasionally a transient increase. Very few cases of exfoliative dermatitis, anaphylactic shock. Contraindications 1. Who are allergic to penicillin antibiotics banned. 2. Infectious mononucleosis, cytomegalovirus infection, lymphocytic leukemia, lymphoma and other patients prone to rash should be using, it should not be applied. Precautions 1. To be done before the drug penicillin skin test positive to banned. 2. Cross allergic reaction: a kind who are allergic to penicillin antibiotics penicillin antibiotics may have other allergies. May also be allergic to penicillamine, or cephalosporins. 3. Should be used with caution in the following conditions: asthma, eczema, hay fever, hives and other allergic diseases history. 4. Renal dysfunction, according to plasma creatinine clearance rate adjustment of medication: Plasma creatinine clearance (ml / min) Half-life (hours) dosing interval (hours) ≥ 30 1 6 ~ 8 15 ~ 29 5 12 5 ~ 14 9 24 5. Ampicillin concentration is higher, the worse the stability, the stability in tandem with temperature increases, and the solution was placed allergens increase, the use of this product shall be promptly dubbed the solution, not long home. 6. Interfere with the diagnosis: Period (1) medication, can occur when copper sulfate method of false-positive urine was measured by enzymatic glucose were not affected; (2) high-dose injection hypernatremia may occur; (3) allows the serum alanine aminotransferase or aspartate aminotransferase. 7. When large doses of regular testing of serum sodium. Pregnant and lactating women drug can be used through the placenta into the fetus, breast milk also contains the product. Report lactating women, although the FDA should be no serious problem, but pregnant women and lactating women still need to be weighed against the application, the application allows the baby after its sensitization and cause diarrhea, rash, candidiasis is infection. Pediatric Use Elderly patients with renal dysfunction in elderly patients required dose adjustment. Drug Interactions 1. When combined with chloramphenicol, in vitro antibacterial activity against Haemophilus influenzae in mixed, chloramphenicol at high concentrations (5 ~ 10mg / L) when the product is no antagonism at low concentrations (1 ~ 2mg / L ampicillin bactericidal effect can decrease the time). Ampicillin antibacterial effect against Staphylococcus aureus in vitro to be inhibited by lincomycin. Escherichia coli, Proteus and in vitro antibacterial activity of Enterobacter for kanamycin strengthened. Ampicillin and gentamicin can accelerate for group B streptococcus in vitro bactericidal effect. 2. This product incompatibility with the following drugs: amikacin, kanamycin, gentamicin sulfate, streptomycin, clindamycin phosphate, lincomycin hydrochloride, colistin methanesulfonate sodium, polymyxin B, amber chloramphenicol, erythromycin ethylsuccinate and erythromycin lactobionate salt, tetracycline injection, novobiocin, epinephrine, metaraminol, dopamine, atropine, hydralazine hydrochloride, hydrolysis protein, calcium chloride, calcium gluconate, vitamin B, vitamin C, amino acid-containing nutrient injection, polysaccharides (e.g. dextran 40), and hydrocortisone sodium succinate, these drugs can decrease the activity of ampicillin. 3. The goods and heavy metals, especially copper, zinc and mercury was incompatibility, because the latter can damage the oxidation thiazole ring. Manufactured by a hose or a zinc compound may also affect its activity stoppers. But also for the oxidant, reductant or hydroxy compounds inactivated. 4. This product is decomposed faster in weak acid glucose injection, to use a neutral liquid solvent. 5. It can be used to strengthen the role of warfarin. 6. Allopurinol when combined with this product, significantly higher incidence of rash, especially prevalent in hyperuricemia, should be avoided in combination with allopurinol. 7. When combined with the product of chloramphenicol for bacterial meningitis, the incidence of long-term sequelae when compared with both single-use is high. 8. Probenecid, aspirin, indomethacin, phenylbutazone, sulfa drugs can reduce the renal excretion of the product from, thus making it the product when combined with increased plasma concentration, prolonged excretion, toxicity may also increase. 9. The goods and disulfiram (aldehyde dehydrogenase inhibitor) should not be shared. 10. This product can stimulate the metabolism of estrogen or reduce its enterohepatic circulation, thus reducing the effect of oral contraceptives. Overdose Excess treatment to symptomatic treatment and supportive therapy, hemodialysis may accelerate drug excretion. ------------------------------------------------------- 产地国家: 希腊 原产地英文商品名: Begalin-P PD (0.5g, 1g) / Vial for Injection Solution 20ml 原产地英文药品名: Sulbactam Sodium, Ampicillin Sodium 中文参考商品译名: Begalin-P PD(0.5克,1克)/瓶 20毫升 中文参考药品译名: 舒巴坦钠,氨苄西林钠 生产厂家中文参考译名: 辉瑞 生产厂家英文名: Pfizer --------------------------------------------- 产地国家: 希腊 原产地英文商品名: Begalin-P PD (1g, 2g) / Vial for Injection Solution 20ml 原产地英文药品名: Sulbactam Sodium, Ampicillin Sodium 中文参考商品译名: Begalin-P PD(1克,2克)/瓶, 20毫升 中文参考药品译名: 舒巴坦钠,氨苄西林钠 生产厂家中文参考译名: 辉瑞 生产厂家英文名: Pfizer |
Begalin-P PD（舒巴坦钠/氨苄西林钠注射液）简介：
Part of the Chinese ampicillin sulbactam prescribing information (for reference only) Common name Ampicillin sulbactam sodium for injection Pharmacology and Toxicology Ampicillin is a penic ... 责任编辑：admin
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