英文药名：Alesion Dry Syrup 1%（Epinastine Hydrochloride） 中文药名：依匹斯汀干糖浆1％ 日文药名：アレジオンドライシロップ１％ 生产厂家：勃林格殷格翰日本公司 药品介绍 分类名称 过敏性疾病治疗药物 商標名 Alesion Dry Syrup 1% 一般名 エピナスチン塩酸塩（JAN） Epinastine Hydrochloride（JAN） Epinastine（INN） 化学名 (±)-3-amino-9,13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepine hydrochloride 化学構造式 分子式 C16H15N3・HCl 分子量 285.77 性状 •在白色至淡黄色粉末，不臭，味微苦。 水，甲醇，乙醇（95）或易溶于乙酸（100），微溶于乙腈。 ·溶解于水10ml本品1.0g液体PH值为3.0至5.5。 熔点 约270℃（分解） 分配系数 9.2×10-2（pH值为7，正辛醇/水） 适应症 瘙痒有过敏性鼻炎，荨麻疹，皮肤疾病（湿疹，皮炎，皮肤瘙痒症） 用法用量 1.过敏性鼻炎 在使用前溶解口服一次0.025〜0.05克/ kg的1日（0.25〜0.5mg的/公斤为盐酸依匹斯汀）的儿童。此外，根据您的年龄和症状调整。 然而，每日剂量不应超过2g（20毫克作为依匹斯汀盐酸盐），为干糖浆。另一个标准剂量的年龄，一般情况下，下面的日剂量的剂量，口服溶解时间为每日给药一次。 年龄：不到3岁或7岁 标准体重：14千克比超过24千克少 每日剂量：0.5〜1克（5〜10毫克的盐酸依匹斯汀） 年龄：6岁以上的老年人。 标准体重：24公斤以上 每日剂量：1〜2克（10〜20毫克的盐酸依匹斯汀） 2.荨麻疹，瘙痒皮肤病（湿疹，皮炎，皮肤瘙痒症） 通过将前使用（0.5毫克/公斤的盐酸依匹斯汀）一旦0.05克口服/公斤1天的儿童。此外，根据您的年龄和症状调整。 然而，每日剂量不应超过2g（20毫克作为依匹斯汀盐酸盐），为干糖浆。另一个标准剂量的年龄，一般情况下，下面的日剂量的剂量，口服溶解时间为每日给药一次。 年龄：不到3岁或7岁 标准体重：14千克比超过24千克少 每日剂量：1克（10毫克的盐酸依匹斯汀） 年龄：6岁以上的老年人。 标准体重：24公斤以上 每日剂量：2克（20毫克的盐酸依匹斯汀） 包装规格 干糖浆1％： 0.5g×100包 1g×100包 100g　瓶 250g　瓶 2g×100包 制造商 日本勃林格殷格翰有限公司 1％依匹斯汀干糖浆在日本批准上市 日本勃林格殷格翰公司（NipponBoehringerIngelheim）和三共株式会社（Sankyo）共同宣布，日本勃林格殷格翰的1%盐酸依匹斯汀干糖浆（epinastinehydrochloride，AlesionDrySyrup1%）于2005年1月19日获准生产。 本品是日本勃林格殷格翰专为儿科使用而开发的新剂型，是日本首个一日1次用药、适合儿科使用的抗组胺类药物干糖浆制剂。本品获准用于变应性鼻炎、风疹和皮肤疾病引起的瘙痒（包括湿疹）等。 依匹斯汀片剂自1994年投放日本市场以来，通过日本勃林格殷格翰和三共双重销售渠道，已经成为日本抗变态反应药物市场上最畅销的药物。此次获准生产的依匹斯汀干糖浆仍将采用与片剂相同的销售模式。 本品是日本批准的首个不含镇静剂且一日1次用药的抗变态反应药物。由于其效果良好、安全性高、不含镇静剂、适应证范围广、药物相互作用少以及心脏毒性低等特性，而被医师和患者高度接受。依匹斯汀片剂是日本口服抗变态反应药物中的主导产品，被广泛用于支气管哮喘、变应性鼻炎、变应性皮肤病等变态反应性疾病的治疗。 完整资料附件：http://bij-kusuri.jp/medicine_data/al_ds/650168_4490014R1021_1_10_content.htm#7 Brand name : Alesion Dry Syrup 1% 　Active ingredient: Epinastine hydrochloride 　Dosage form: white to yellowish white granulated powder 　Print on wrapping: (Face) 1%, (5mg/0.5g, 10mg/1g, 20mg/2g), company logo, Boehringer Ingelheim, recycle mark (Back) Alesion Dry Syrup 1%, (5mg/0.5g, 10mg/1g, 20mg/2g), company logo, Boehringer Ingelheim Effects of this medicine This medicine is a selective H1-receptor antagonist and also has an antiallergic effect by inhibiting the release of allergy-inducing substances such as histamine. Usually, this medicine is used to treat allergic rhinitis, urticaria, and pruritus due to skin diseases (eczema, dermatitis, pruritus cutaneous). Before using this medicine, be sure to tell your doctor and pharmacist •If you have ever had any unusual or allergic reaction (itch, rash etc.) to any medicines. If you have liver disease or a history of liver disease. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •General dosage regimen: Allergic rhinitis, Usually for children, 0.025-0.05g/kg (0.25-0.5mg/kg of epinastine hydrochloride) is orally administered once daily by dissolving the medicine in water just before use. Standard daily dosage for children aged between 3 to 6: 0.5-1g(5-10mg of epinastine hydrochloride), for children aged 7 or above: 1-2g(10-20mg). Asthma and skin diseases such as urticaria and eczema, Usually for children, 0.05g/kg (0.5mg/kg of epinastine hydrochloride) is orally administered once daily by dissolving the medicine in water just before use. Standard daily dosage for children aged between 3 to under 7: 1g(10mg), aged 7 or above: 2g(20mg). The dosage may be adjusted according to patient's age and severity of symptoms. For either condition, it should not exceed 2g of dry syrup (20mg of epinastine hydrochloride). Follow your doctor's instructions. •If you are ordered to take this medicine on regular schedule and you missed a dose, take as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take a double dose to make up for the missed dose. •If you took too much of this medicine (more than ordered), check with your doctor/pharmacist. •Do not stop taking this medicine without the instructions of your doctor. Precautions while taking this medicine •Use caution when operating machinery or engaging in hazardous activities. This medicine may cause drowsiness. Parents of children taking this medicine should pay close attention to the safety of their childrens' activities. Possible adverse reactions to this medicine Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: drowsiness, headache, bitter taste, edema (face, limbs), rash, urticaria, itching, erythema, frequent urination. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. •generalized fatigue, loss of appetite, yellowness of the skin or conjunctiva [hepatic dysfunction, jaundice] •nose bleeding, gum bleeding, subcutaneous bleeding of the hands and feet (bruise) [thrombocytopenia] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •Keep out of the reach of children. Store away from heat, moisture and light. •Discard unused medicine. For healthcare professional use only: Day Month ear 　　　　  For further information, talk to your doctor or pharmacist.