英文药名：Mydrin-P ophthalmic solution（Tropicamide/Phenylephrine Hydrochloride）

中文药名：托吡卡胺/盐酸去氧肾上腺素滴眼液

生产厂家：参天制药
分类名称
检查用散瞳眼药水
Mydrin-P ophthalmic solution
1.托吡卡胺
一般名
トロピカミド（Tropicamide）
化学名
(2RS)-N-Ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide
構造式

分子式
C17H20N2O2
分子量
284.35
性状
本品是一种白色结晶粉末，无臭，味微苦。
此产品在乙醇（95）或易溶于氯仿，微溶于水或乙醚，并在石油醚中几乎不溶。
此产品溶于稀盐酸。
本品1.0g溶解于水500mL的液体的pH为6.5至8.0。
熔点
96〜99℃
2. 盐酸去氧肾上腺素
一般名
フェニレフリン塩酸塩
（Phenylephrine Hydrochloride）
化学名
(1R)-1-(3-Hydroxyphenyl)-2-methylaminoethanol monohydrochloride
構造式

分子式
C9H13NO2・HCl
分子量
203.67
性状
本品是一种白色结晶或结晶性粉末，无臭，味微苦。
这是非常易溶于水，并且易溶于乙醇（95），并在乙醚中几乎不溶。
本品1.0g的溶液溶解于100毫升水的pH为4.5-5.5。
熔点
140〜145℃
[注意]
本剤进行眼底检查或类似的灌输，请给注意，如下面给患者。
(1) 瞳孔（瞳孔），因此是更大的4-5个小时，眼睛视物模糊，但会比平常眼花缭乱的感觉，它可以自然痊愈。
(2) 本次考试后，半天的位置是避免驾驶或危险的工作，如汽车
(3) 检查结束后，您可以联系负责人的考核，如果立即症状，如发生以下情况，请咨询附近的眼科医生。
1）如果头痛和眼痛的检查后，突然发生了。
2）如果你已经检查的第二天，有症状，如以下。
1.瞳孔大于平常（左侧的不同大小和瞳孔的右侧）
2.视力模糊是不是更好。
3.令人眼花缭乱的比平常。
4.疼痛的头和眼睛
【注】检查结束后，将在年初正常视力和盐酸毛果芸香碱滴眼液滴眼恢复如Sanpiro滴眼液1％。
药效药理
1. 散瞳作用
当白兔的滴眼液是托和盐酸去氧肾上腺素各种比例的混合滴注，由轮廓分布瞳孔的收缩托瞳孔括约肌，盐酸去氧肾上腺素导致瞳孔散大的放松。
此外，托和苯肾上腺素的协同，配合比两者的组合效果是1：1散瞳效果出现。
2.调节麻痹作用
因为视力障碍和儿童的折射检查的内斜视，这种药物灌输1-2次，调整麻痹效果，一天三次0.5％或1％阿托品，与此相比，在为期三天的滴眼剂的效果，这代理商调节麻痹作用较阿托品弱。
适应病症
瞳孔散大与诊断和治疗为目的的调控瘫痪
用法用量
瞳孔散大，通常情况下，一次1-2滴两种眼药水，或在3-5分钟的间隔2次眼药水一滴一次。监管瘫痪，通常情况下，它在3-5分钟的时间间隔灌输2-3次一滴一次。
此外，根据症状进行调整。
包装规格
塑料滴管：5毫升×10本，10毫升

生产商：
参天制药有限公司
完整处方资料附件：http://www.info.pmda.go.jp/go/pack/1319810Q1053_1_08/
Mydrin-P ophthalmic solution（Tropicamide/Phenylephrine Hydrochloride）
Mydrin-P ophthalmic solution（ミドリンP点眼液） 
Brand name : Mydrin-P ophthalmic solution
　Active ingredient: Tropicamide
 Phenylephrine hydrochloride
　Dosage form: colorless to faint yellow, limpid, ophthalmic solution, 5 or 10mL, (bottle) pale violet, (cap) white
　Print on wrapping: 
Effects of this medicine
This medicine acts on the muscle of parasympathetic innervation and eases the tension of the eye, or acts on the muscle of sympathetic innervation and contracts it in order to dilate the pupil, or in order to loosen the muscle of focus adjustment.
It is usually used to treat inflammation of the eye such as iritis, or to improve focus adjustment of the eye. It is also used to examine eyeground or refraction of the eye.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have: glaucoma, predisposition of increased intraocular pressure such as narrow angle or shallow anterior chamber, hypertension, arteriosclerosis, heart disease, diabetes, or hyperthyroidism.
If you wear contact lenses.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•For mydriasis: In general, apply 1 to 2 drops at a time, or apply 1 drop at a time, 2 times at intervals of 3 to 5 minutes.
For accommodation paralysis: In general, apply 1 drop at a time, 2 to 3 times at intervals of 3 to 5 minutes.
In any case, the dosage may be adjusted according to your symptoms. Strictly follow the instructions.
•If you are a child patient, you should especially follow your doctor's instructions.
•Before applying, wash your hands thoroughly with soap and running water. Pull down your lower eyelid so that the dropper tip does not touch eye or eyelashes and apply the medicine. After applying, keep your eyes closed for 1 to 5 minutes pressing the inner corner of the eye lightly. Wipe off any excess liquid with a clean gauze or tissue. If you need to apply other eye drops at the same time, wait more than 5 minutes.
•If you miss a dose, apply the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should not apply two doses at one time.
•If you accidentally apply more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop applying this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•This medicine may cause sensitive to bright light or blurred vision. Do not operate dangerous machinery such as driving a car until these symptoms recover. If your eyes become more sensitive to bright light, wear sunglasses as necessary.
•Effects of this medicine may carry over after applying for the examination. If you continue having the pupil is larger than usual (right and left pupils are different-sized), blurred vision, sensitive to bright light than usual, headache/eye pain (without typical reason such as cold) on the next day, contact the person in charge of the examination or see your doctor immediately.
Possible adverse reactions to this medicine
The commonly reported adverse reactions include blepharitis (erosion of eyelids, redden/swollen eyelids), eyelid dermatitis, itch, rash, hives, conjunctivitis (bloodshot/swollen eyes, eye mucus), corneal epithelial disorder (eye pain, focus disorder, foreign body sensation in eyes), increased intraocular pressure (eye pain, focus disorder, headache), dry mouth, nausea/vomiting, flush face (red face), tachycardia, increased blood pressure, and headache. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•erythema, respiratory distress, swollen eyelids [shock, anaphylactoid symptoms]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of reach of children. Store away from direct sunlight and heat.
•Discard the remainder. Do not store them.
Santen Pharmaceutical Co.,Ltd.External
Revised: 8/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.