部份中文L-METHYL-MC片处方资料（仅供参考）
通用名：左亚叶酸钙盐/核黄素/氰钴胺素/吡哆醇
剂型：包衣片剂
1-甲基MC片
处方膳食补充剂
1-甲基MC片剂说明
1-甲基MC是一种口服处方膳食补充剂专门配制用于治疗患有需要增加叶酸水平独特营养需要饮食管理。
适应症和用法
1-甲基MC片剂
1-甲基MC被指示为如由授权医生确定患者的不同营养需求需要膳食补充的。
1-甲基MC应许可医生的监督下进行。
禁忌
此产品是禁忌在病人与已知的超敏性的任何成分。
警告
谨慎的患者推荐使用双极性疾病的病史。
注意事项
一般
叶酸，当如在剂量单一药剂每日约0.1mg给药，可能掩盖的维生素B12缺乏（具体而言，叶酸的施用可能逆转B12缺乏的血液学表现，包括恶性贫血，而不是解决神经系统表现的检测）。单纯叶酸治疗是不够的治疗维生素B12缺乏的。
患者信息
1-甲基MC是只能在许可的医疗监督要使用的处方膳食补充剂。
SPL UNCLASSIFIED SECTION
A medical food for the dietary management of hyperhomocysteinemia.
Description
Each round coated blue colored tablet contains:

Dietary Ingredients:
L-methylfolate Calcium	6 mg
Riboflavin	5 mg
Pyridoxine (as Pyridoxine HCl)	50 mg
Cyanocobalamin	1 mg

Microcrystalline Cellulose, Pyridoxine HCl,Opadry II Blue #40L10890 (Polydextrose, Hypromellose HPMC 2910, FD&C Blue #1 Aluminum Lake, Triacetin, Titanium Dioxide, Peg 8000). Stearic Acid (Vegetable Source), Croscarmellose Sodium, L-methylfolate Calcium, Riboflavin, Silicon Dioxide, Magnesium Stearate (Vegetable Source), Opadry II Clear #Y-19-7483, (Hypromellose HPMC 2910, Maltodextrin, Peg 400), Cyanocobalamin.
L-Methyl-MC Tablets do not contain sugar, lactose, yeast or gluten.
Indication and Usage
L-Methyl-MC Tablets are indicated for the distinct nutritional requirements of individuals under medical supervision for hyperhomocysteinemia; with particular emphasis for individuals diagnosed with or at risk for mild to moderate: cognitive impairment1, vascular dementia2, or Alzheimer's disease3.
Precautions
Folates, when administered as a single agent in doses above 0.1mg daily, may obscure pernicious anemia in that hematologic remission can occur while neurological manifestations remain progressive. The 1 mg of cyanocobalamin contained in L-Methyl-MC Tablets has been shown to provide an adequate amount of cyanocobalamin to address this precaution4. A safe upper limit of 100 mg per day has been established for the unsupervised medical use of pyridoxine. Consider all sources of pyridoxine supplementation when prescribing L-Methyl-MC Tablets.
Adverse Reactions
While allergic sensitization has been reported following both oral and parenteral administration of folic acid, allergic sensitization has not been reported with the use of L-Methylfolate Calcium. Paresthesia, somnolence, nausea and headaches have been reported with pyridoxine. Mild transient diarrhea, polycythemia vera, itching, transitory exanthema and the feeling of swelling of the entire body has been associated with cyanocobalamin. Transient headaches have been reported infrequently with the use of L-Methyl-MC Tablets. If headaches should occur with the use of L-Methyl-MC Tablets consult with your medical practitioner.
Contraindications
Known hypersensitivity to any of the components in the product is a contraindication.
Drug Interactions
L-Methyl-MC Tablets added to other drugsHigh dose folic acid may result in decreased serum levels for pyrimethamine and first-generation anticonvulsants (carbamazepine, fosphenytoin, phenytoin, phenobarbital, primidone, valproic acid, valproate). This may possibly reduce first generation anticonvulsants effectiveness and/or increasing the frequency of seizures in susceptible patients. While the concurrent use of folic acid and first generation anticonvulsants or pyrimethamine may result in decreased efficacy of anticonvulsants, no such decreased effectiveness has been reported with the use of L-methylfolate. Nevertheless, caution should be used when prescribing L-METHYL-MC TABLETS among patients who are receiving treatment with first generation anticonvulsants or pyrimethamine. Pyridoxine should not be given to patients receiving the drug levodopa, because the action of levodopa is antagonized by pyridoxine. However, pyridoxine may be used concurrently in patients receiving a preparation containing both carbidopa and levodopa. Capecitabine (Xeloda®) toxicity may increase with the addition of leucovorin (5-formyltetrahydrofolate) (folate).
Drugs added to L-METHYL-MC TABLETSAntibiotics may alter the intestinal microflora and may decrease the absorption of cyanocobalamin. Cholestyramine, colchicines or colestipol may decrease the enterohepatic reabsorption of cyanocobalamin. Metformin, para-aminosalicylic acid and potassium chloride may decrease the absorption of cyanocobalamin. Nitrous oxide can produce a functional cyanocobalamin deficiency. Several drugs are associated with lowering serum folate levels or reducing the amount of active folate available. First generation anticonvulsants (carbamazepine, fosphenytoin, phenytoin, phenobarbital, primidone, valproic acid, valproate) and lamotrigine (a second-generation anticonvulsant) may decrease folate plasma levels. Information on other second-generation anticonvulsants impact on folate levels is limited and cannot be ruled out. Methotrexate, alcohol (in excess), sulfasalazine, cholestyramine, colchicine, colestipol, L-dopa, methylprednisone, NSAIDs (high dose), pancreatic enzymes (pancrelipase, pancratin), pentamidine, pyrimethamine, smoking, triamterene, and trimethoprim may decrease folate plasma levels. Warfarin can produce significant impairment in folate status after a 6 month therapy.
Patient Information
L-Methyl-MC Tablets is a medical food for use only under medical supervision.
Dosage and Administration
Usual adult dose is one to two tablets daily or as directed by your medical practitioner. L-Methyl-MC Tablets is not recommended for use with children under the age of twelve.
How Supplied
Available as a round coated blue colored tablet. Debossed with "V360" on one side and blank on the other. Commercial product is supplied in bottles of 90 tablets (76439-360-901). Use under medical/physician supervision.
1 Virtus Pharmaceuticals, LLC does not represent this product code to be a National Drug Code (NDC) number. Instead, Virtus Pharmaceuticals, LLC has assigned a product code formatted according to standard industry practice to meet the formatting requirements of pharmacy and health insurance computer systems.
StorageStore at controlled room temperature 15ºC to 30ºC (59ºF to 86ºF) (See USP).
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bbabfd5c-e341-4157-98c6-9e168cf973dd

注：以下产品不同规格和不同价格，采购以咨询为准
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