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OXIFAST for Injection(盐酸羟考酮注射液)

2016-06-01 07:29:54  作者:新特药房  来源:互联网  浏览次数:0  文字大小:【】【】【
简介: 英文药名:OXIFAST for Injection(Oxycodone hydrochloride hydrate) 中文药名:盐酸羟考酮注射液 生产厂家:盐野义制药 オキファスト注10mg/オキファスト注50mg 治疗类别名称癌痛治疗性注射 ...

英文药名:OXIFAST for Injection(Oxycodone hydrochloride hydrate)

中文药名:盐酸羟考酮注射液

生产厂家:盐野义制药

オキファスト注10mg/オキファスト注50mg

治疗类别名称
癌痛治疗性注射
欧文商標名
OXIFAST
一般的名称:オキシコドン塩酸塩水和物(JAN)[日局]
Oxycodone Hydrochloride Hydrate
化学名:(5R)-4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one monohydrochloride trihydrate
分子式:C18H21NO4・HCl・3H2O
分子量:405.87
化学構造式:

性状:
它是一种白色结晶粉末。
水,易溶于甲醇或乙酸(100),乙醇(95),以微溶,在乙酸酐中微溶,并在乙醚中几乎不溶。
光的影响。
适应病症
镇痛(各种癌症中,重度疼痛)
用法用量
成年人:一天持续静脉注射7.5〜250毫克。此外,增加或减少取决于患者的年龄和症状。
药效药理
1. 药理作用
鎮痛作用
它是研究硫酸吗啡作为镇痛作用的对照药物。
使用(包括口服)进行了研究小鼠热板法,尾压法,醋酸扭体法及大鼠甩尾法的结果,三到六倍比硫酸吗啡盐盐酸羟考酮ED50值,效价比在展出的3-5倍更强的止痛效果。
表5 鎮痛作用参照
2. 作用机序
作为通过一个μ阿片受体吗啡将指示的镇痛作用。
药效药理の表
表5:鎮痛作用

試験法  動物種  ED50(95%信頼限界)mg/kg
オキシコドン塩酸塩 
ED50(95%信頼限界)mg/kg
モルヒネ硫酸塩 
Hot plate法  マウス  3.2(0.9-5.3)  15.6(8.6-21.9) 
Tail pressure法  マウス  3.5(2.7-4.5)  8.9(4.8-12.7) 
酢酸ライジング法  マウス  2.3(1.6-4.0)  7.0(4.6-15.6) 
Tail flick法  ラット  3.8(1.8-5.5)  21.6(19.2-24.2)
包装规格
注:
10毫克:1毫升   10管


注:50毫克:5毫升   5管


制造厂商
盐野义制药有限公司
注:以上资料仅供参考,使用以原处方为准:http://www.info.pmda.go.jp/go/pack/8119400A1025_1_04/
OXIFAST for Injection(Oxycodone hydrochloride hydrate)
OXIFAST for Injection 10mg(オキファスト注10mg) 
Brand name : OXIFAST for Injection 10mg
 Active ingredient: Oxycodone hydrochloride hydrate
 Dosage form: injection
 Print on wrapping: 
OXIFAST for Injection 50mg(オキファスト注50mg)  
Brand name : OXIFAST for Injection 50mg
 Active ingredient: Oxycodone hydrochloride hydrate
 Dosage form: injection
 Print on wrapping:
Effects of this medicine
This medicine acts on opioid receptors in the central nervous system, thereby relieving pain.
It is usually used as an analgesic for various types of cancer accompanied with moderate to severe pain.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have respiratory function disorder, bronchial asthma, heart failure, a history of convulsions, paralytic ileus, acute alcoholic poisoning, hemorrhagic colitis or bacterial diarrhea.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, this medicine is continuously administered by intravenous or subcutaneous injection.
•Duration and dose for use are determined according to the effects of this medicine. Consult wih your doctor about concrete schedule for use.
Precautions while taking this medicine
•Since this medicine may cause drowsiness or dizziness, avoid driving a car or operating dangerous machinery.
•Alcohol may enhance the effects or the adverse reactions of this medicine.
•If you are breastfeeding, avoid breastfeeding while using this medicine.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include drowsiness, somnolence, constipation, nausea, vomiting, redness, rash and hives. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•facial pallor, breathlessness, swelling around eyes and/or mouth (lips)  [shock, anaphylaxis]
•inability to stop using the medicine even when you attempt to discontinue it, and desire for continuing its use  [dependence]
•breathlessness, shortness of breath  [depressed respiration]
•disoriented, speaking in tongues, feeling as if the thing which is not in fact were visible or audible  [confusion, delirium]
•constipation, feeling of fullness in abdomen, severe pain in abdomen  [paralytic ileus, toxic megacolon]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Shionogi & Co., Ltd.Injection
Revised: 7/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.

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