英文药名：MADOPAR Combination Tablet（Levodopa/Benserazide hydrochloride）

中文药名：左旋多巴/盐酸苄丝肼组合片

日文药名：マドパー配合錠

生产厂家：中外制药
治疗类别名称
帕金森治疗药物
适应病症
帕金森氏病，帕金森氏综合症
用法用量
在左旋多巴未处理例的情况下
成人：初始日剂量的1-3粒1-3次，饭后，逐渐增大由每2-3天1〜2片每日剂量后口服给药，一天作为维持剂量3-6锁定口服给药。
在给药左旋多巴例的情况下
成人：初始每日剂量切换到对应于左旋多巴量（每片这种药物在含有左旋多巴100毫克）在施用大约五分之一的左旋多巴量，它被分成三次，饭后口服给药，逐渐增加作为维持剂量口服给药或逐渐下降，每日剂量3-6片剂。
应当指出的是，增加或减少取决于患者的年龄和症状。
药效药理
左旋多巴，进入通过血脑屏障脑，通过多巴脱羧酶脱羧成为多巴胺，施加帕金森治疗作用。
盐酸苄丝肼与脱羧酶的抑制作用，不迁移到正常剂量的大脑。
代谢左旋多巴的多巴胺未在此抑制大脑，抑制多巴脱羧酶的在选择性地诺盖的动作。
通过在血液中的苄丝肼盐酸混合左旋多巴因此，儿茶酚胺（多巴胺，去甲肾上腺素等）降低，因为左旋多巴浓度增加，增加左旋多巴过渡量进入大脑，大脑多巴胺量增加。
包装规格
组合片剂
100片（PTP10粒×10），1000片（PTP10粒×100）

制造厂商
中外制药有限公司
MADOPAR Combination Tablet（マドパー配合錠） 
Brand name : MADOPAR Combination Tablet
　Active ingredient: Levodopa
 Benserazide hydrochloride
　Dosage form: pale red tablet (φ: approx. 9mm, thickness: approx. 3.3mm)
　Print on wrapping: マドパー配合錠
Effects of this medicine
The active ingredient of this medicine, Levodopa, changes into dopamine in the brain and improves symptoms of Parkinson disease and etc. It is usually used to treat Parkinson disease and parkinsonian syndrome.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you are a patient with glaucoma, hepatic/renal disorder, diabetes, heart/lung disease, bronchial asthma, endocrine system disease, neurological manifestation such as suicide tendency, or osteomalacia.
If you have/had gastric/duodenal ulcer.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•General dosage regimen: If you have not taken Levodopa so far: For adults, take 1-3 tablet(s) in 1-3 divided doses a day, after meal on the first day. Gradually increase the dosage by 1-2 tablet(s) a day every 2-3 days. The maintenance dosage is 3-6 tablets a day. It should be adjusted according to your disease, age and symptoms. Strictly follow the instructions of your doctor/pharmacist.
If you are taking Levodopa now: For adults, take Levodopa equivalent to about 1/5 of the daily amount which you are taking (1 tablet contains 100mg of Levodopa) on the first day. Take it in 1-3 divided doses a day, after meal. Gradually increase or decrease the amount of this medicine after that. The maintenance dosage is 3-6 tablets a day. It should be adjusted according to your disease, age and symptoms. Strictly follow the instructions of your doctor/pharmacist.
•Take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take a double dose to make up for the missed dose.
•If you took too much of this medicine (more than ordered), check with your doctor/pharmacist.
•Do not stop taking this medicine without the instructions of your doctor.
Precautions while taking this medicine
•This medicine may cause sudden and temporary sleepiness, diminished attention, or decreased reflection ability. Do not drive a car, work at heights, or operate dangerous machinery.
Possible adverse reactions to this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: involuntary movement, nausea/vomiting, loss of appetite, hallucination, sleeplessness, rash, urticaria-like eczema.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•breathlessness with fever, stiff muscles in the limbs, absent-mindedness, loss of consciousness [syndrome malin]
•hallucination, depression and indisposition, loss of appetite, lassitude, sleeplessness, impaired judgment, inability to have normal thoughts [hallucination, depression, confusion]
•bad abdominal pain, vomiting, vomiting of blood [worsening of gastric/duodenal ulcer]
•easy fatigability, anemia [hemolytic anemia]
•sudden and temporary sleepiness [sudden onset of sleep]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store at room temperature (1-30℃), away from light and moisture.
•Discard the remainder. Do not store them. Ask the pharmacist how to discard.
Chugai Pharmaceutical Co., Ltd.Internal
Revised: 9/2009
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.