The efficacy and tolerability of Hirudoid forte as gel and cream were studied in 513 patients with superficial venous disorders or haematoma. The efficacy was assessed on the basis of a special score (Schone).

    Schone研究了特强喜疗妥凝胶和软膏的疗效和耐受性，受试对象为513例浅表静脉疾病或血肿患者。通过特定的评分制对疗效进行了评估。

 

    The following tables show the results of treatment. Cream and gel showed a similar effcacy in the different indications. The patients reported the pleasant cooling effect of the gel. The tolerability of Hirudoid forte cream and gel was equally good.

    下附的结论显示了疗效。对于不同的适应症，软膏和凝胶的疗效是相似的。患者反应凝胶的清凉效果另人愉快。特强喜疗妥软膏和凝胶耐受性都相当好。

 

    Levai reported on 243 patients who were treated with Hirudoid gel for different venous disorders of the lower extremities. The efficacy was judged according to the following parameters: status of pain, sensation of tension, absorption of infiltrates and haematomas, and period of time until subsidence of symptoms.

    Levai报道了用喜疗妥凝胶治疗243位末梢静脉疾病患者。疗效是通过以下参数评估的：疼痛程度、张力、渗出和血肿的吸收以及症状缓解所需的时间。

 

    After only 7 days of treatment about 72 to 97% of the patients depending on the specific disorder were without symptoms. The author emphasized the excellent tolerability of the product.

    仅仅治疗7天后，由于疾病的不同，72％至97％的患者症状消失。作者强调了产品的耐受性极佳。

 

    Alter used Hirudoid gel for the treatment of 188 patients suffering from varicosities, haematomas and acute phlebitis. The author emphasized the fact that complete freedom from the complaints was already observed after a few days. In the cases of varicosis or thrombophlebitis for which the results of therapy were indicated as very good, freedom from pain was achieved after only 3-5 days. Swelling and erythema receded after a few days. Even large haematomas responded successfully; they were completely absorbed within a week. Hirudoid gel was very well tolerated. The speedy penetration into the skin and the cooling action were felt to be particularly pleasant.

    Alter应用喜疗妥凝胶治疗了共188位静脉曲张、血肿和急性静脉炎患者。作者强调仅仅用药很少几天后症状就完全缓解了。对于静脉曲张或血栓性静脉炎的疗效非常好，疼痛的缓解仅需用药3－5天。水肿和红斑也于用药很少几天后减轻了。甚至很大的血肿对于药物的反应亦非常成功，它们在一周内完全吸收了。喜疗妥凝胶的耐受性非常良好。特别是其对于皮肤的快速渗透和清凉作用特别令人愉快。

 

    Grotz used Hirudoid forte cream for the treatment of 244 patients with superficial phlebitis (n = 118), haematomas (n = 55), and painful varicosis with a risk of thrombophlebitis (n = 71). Depending on the specific disorder, the treatment lasted for 6-15 days. Parameters for the assessment of success of therapy were the cardinal symptoms of inflammation: swelling, reddening, increase of body temperature, spontaneous pain and pain on pressure. In patients with haematomas besides the status of pain, the extension and discoloration of the effusions were assessed. The mode of administration massage of the cream into the skin or cream dressing had no influence on the result of treatment; the tolerability was considered to be very good.

    Grotz用特强喜疗妥软膏治疗了244位患者，其中浅表静脉炎患者118例，血肿患者55例和疼痛性静脉曲张并有发展为血栓性静脉炎倾向的患者71例。根据不同的疾病，治疗持续了6－15天。以炎症的主要症状作为疗效的评估参数：水肿、充血、皮温升高、自发性疼痛和压力性疼痛。血肿患者除了疼痛的程度，还评估了渗出的范围和色泽。将软膏按摩入皮肤的方式或软膏敷料对疗效无影响，药物的耐受性非常良好。

 

In a retrospective study in 45 patients O""Herlihy compared the influence of Hirudoid cream with oral analgesics and anti-inflammatory agents on superficial thrombophlebitis caused by pregnancy. The clinically relevant characteristics of the group treated with Hirudoid (23 patients) and the control group (22 patients) were comparable. There were statistically significant differences with regard to the duration of pain (p < 0.001) and symptoms of inflammation (p < 0.01) in favour of the Hirudoid group. Although the evidence has been evaluated retrospectively, these data suggest that the local action of Hirudoid cream provides more rapid relief than traditional treatment with orally-administered anti-inflammatory analgetics. It therefore appears to be a useful adjunct in the management of superficial thrombophlebitis in the legs

在一回顾性研究中，O""Herlihy比较了喜疗妥软膏和口服止痛剂及消炎药对于45位因怀孕而引起的浅表血栓性静脉炎患者的疗效。喜疗妥治疗组（23例患者）和对照组（22例患者）的相关临床特征具有可比性。

 

Florian reported on the favorable results achieved with Hirudoid cream in the treatment of inflammatory venous disorders in 98 outpatients of a phlebological clinic. The efficacy of the treatment in regard to the symptoms of pain, tiredness and feeling of heaviness of the legs were impressive for the patient. In addition, an improvement of the parameters such as swelling, induration and pigmentation could be verified.

Florian报道用喜疗妥软膏治疗98位患有静脉疾病的门诊患者，疗效令人满意。患者对于药物有关改善疼痛和腿部疲惫及沉重感的疗效印象深刻。此外，还证实药物能改善水肿、硬化和色素沉着。

 

In a further published study the same author confirms the great efficacy of Hirudoid and Hirudoid forte in the treatment of 90 patients with venous, inflammatory and traumatic diseases of the lower extremities. In the case of severe and recurrent complaints patients were treated with the product containing the higher dose, i.e. Hirudoid forte. Doppler sonography and skin thermometry were used in 10 patients to verify the assessment of the success of the treatment. Doppler sonography confirmed the clinical assessment of the therapeutic success.

在所发表的进一步的研究中，该作者还证实了喜疗妥和特强喜疗妥在治疗肢体末端静脉炎症的卓越疗效，共有90例患者接受了治疗。对于那些症状严重的复发病例用高浓度药物治疗，如特强喜疗妥。为了进一步证实和评估药物的有效性，对其中的10位患者进行了多谱勒超声和皮温测试。多谱勒超声检查证实了临床验证的治疗有效性。

 

Cutaneous thermometry makes it possible to verify the course of an inflammatory process and the anti-inflammatory action of specific drug therapies. In this study, thermometry showed that the temperature of the inflamed tissue was decreased as a result of treatment.

皮温测定使对炎症发展过程和特定制剂的抗炎作用的监测成为可能。在这项研究中，皮温测试显示炎症组织的温度由于治疗而降低了。

 

Compression and the use of topical preparations represent the basic therapy for many venous disorders. The excellent tolerability of Hirudoid and Hirudoid forte is therefore of particular importance.

局部压迫和外用制剂是许多静脉疾病的基础治疗。喜疗妥和特强喜疗妥由于其极好的耐受性而特别重要。

 

In an open multicentre study 813 patients were treated with Hirudoid cream, who suffered from varicose syndrome (varicose veins, venous congestion, spider varicosities, follow-up of vein stripping, thrombophlebitis, infusion phlebitis), acute posttraumatic conditions (contusions, strains, haematomas) and scars (Eckenberger/van Aubel).A thin layer of cream was applied to the affected region once or several times daily and gently massaged in.

Eckenberger/van Aubel在一开放性研究中，用喜疗妥软膏治疗813位患者，他们分别患有肿胀综合症（静脉曲张、静脉充血、蜘蛛状静脉曲张、继发性静脉脱膜、血栓性静脉炎、输注性静脉炎）、急性外伤（檫伤、扭伤和血肿）和疤痕。一天一次或数次在患处薄薄地涂一层，并轻轻按摩入皮肤。

 

The criteria for the assessment of efficacy were pain at rest, pain on pressure and movement, feeling of tension and heaviness, edema, leg cramps, haematoma, erythema, palpable indurations, duration of treatment up to improvement and up to freedom from symptoms and signs and global assessment.

疗效的评估标准包括：静止性疼痛、压力和运动性疼痛、张力和沉重感、水肿、腿部抽筋、血肿、红斑、可触及硬化、症状和体症缓解和痊愈所需的时间，全球评估标准。

 

On the average improvement was seen at the end of a week. Complete freedom from symptoms and signs was achieved in 84% of patients at the end of a fortnight. Chronic venous disorders and scar formation required longer treatment. The investigating physicians assessed the skin tolerability of Hirudoid and Hirudoid forte as good or very good in 97,3 % of all cases.

症状和体症改善所需的平均时间为一周。两周时84％的患者症状和体症完全消失。慢性静脉疾病和疤痕形成所需治疗期较长。调查医师对喜疗妥或特强喜疗妥的皮肤耐受性评价为好或非常好的病例百分比为97.3％。

 

Taterka treated 68 cases of acute varicophlebitis, varicose thrombophlebitis, inflammatory conditions following phlebosclerosation and conditions following thrombectomy with Hirudoid cream and long-term compression bandages. Within the one week therapy with Hirudoid the inflammatory signs in all patients had either completely subsided or had improved to such an extent that a complete healing was achieved. Scar formation was avoided, and disfiguring pigmentation in the paravenous connective tissue was hardly ever observed.

Taterka用喜疗妥软膏和长期绷带压迫治疗了68例急性静脉曲张、曲张性血栓性静脉炎、静脉硬化继发炎症和血栓切除术后患者。在用喜疗妥治疗的一周期间，所用患者的炎症均显著减轻或痊愈了。并且避免了疤痕的形成，而且几乎没有观察到结缔组织有色素沉着。

 

The simple and safe therapy with Hirudoid was stressed in particular; symptoms of irritation were not observed in any of the cases. The excellent results of treatment of varicose thrombophlebitis indicate that compression bandaging with Hirudoid cream may be used for routine prophylaxis of inflammatory reactions and for the improvement of cosmetic results after sclerotherapy of varicose veins.

研究者特别强调了用喜疗妥治疗方便、安全，未在任何病例观察到有刺激症状。研究结论显示，喜疗妥软膏联合绷带压迫治疗曲张性血栓性静脉炎疗效卓越，可以作为静脉曲张术后的预防炎症反应和促进术后恢复。

 

Klempa/Balser, who had treated 112 patients with Hirudoid gel after vein stripping, confirmed :"Hirudoid gel makes it possible to considerably reduce the postoperative period of healing after vein stripping." In this study the postoperative period of healing was reduced by more than 50% as a result of the treatment with Hirudoid.

Klempa和Balser用喜疗妥凝胶治疗了112例静脉脱膜患者后证实：“喜疗妥凝胶使静脉脱膜术后的痊愈时间显著缩短了”。在这项研究中，用喜疗妥治疗后，术后恢复至痊愈所需的时间缩短了至少50％。

 

The efficacy of Hirudoid was verified in particular in those patients who had had operations at both legs during one session. Although the results of surgery were comparable at the legs, the leg treated with Hirudoid healed approximately twice as fast as the other leg.

特别是对于那些双腿同时接受手术的患者，喜疗妥的疗效得到了进一步验证。虽然手术状况在双腿具有可比性，用喜疗妥治疗侧腿部的痊愈时间大约是对侧的两倍。

 

No local reactions as result of the treatment with Hirudoid were observed.

未观察到因应用喜疗妥治疗而引起的局部反应。