摘 要:研究单唾液酸四己糖神经节苷脂(GM1)对帕金森病(PD)的治疗作用。运用选择性偏侧(右侧)PD大鼠模型,观测正常对照组、PD组(造模后14d)、PD生理盐水(NS)治疗组和GM1治疗组(10mg/kgIPqd、连续14d),阿朴吗啡(APO)诱发的旋转行为改变和纹状体线粒体钙(MCa)、钙调素(CaM)含量改变。PD组表现明显的APO诱发的旋转行为(≥6r/min),黑质损伤侧(右侧)纹状体MCa、CaM含量与正常对照组比较显著性升高(P<0.01);GM1治疗组APO诱发的旋转行为明显好转,黑质损伤侧纹状体MCa、CaM含量与PD组比较无显著差异性(P>0.05)。GM1能改善实验性PD的部分行为、生化改变,对PD具有治疗作用。
关键词:GM1;帕金森病;线粒体钙;钙调素
作者简介:徐仁,男,1969年生,医学博士。现址:江西省南昌市江西医学院第一附属医院神经科,330000
作者单位:徐仁四(同济医科大学附属协和医院神经科,武汉 430022)
童萼塘(同济医科大学附属协和医院神经科,武汉 430022)
孙圣刚(同济医科大学附属协和医院神经科,武汉 430022)
梅元武(同济医科大学附属协和医院神经科,武汉 430022)
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