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盐酸匹罗卡品治疗干燥综合症的干燥症状有效

2009-09-01 09:27:18 作者：新特药房来源：中国新特药网浏览次数：625 文字大小：【大】【中】【小】

简介： 我们研究了盐酸匹罗卡品（9 mg/d,每日分3次）口服治疗21例干燥综合症患者的干燥症状疗效，其中19例患者持续服用至少1个月，口干和眼干主观症状改善率分别为53%（10例）和26%（5例）。出汗的副作用最多见 ...

我们研究了盐酸匹罗卡品（9 mg/d,每日分3次）口服治疗21例干燥综合症患者的干燥症状疗效，其中19例患者持续服用至少1个月，口干和眼干主观症状改善率分别为53%（10例）和26%（5例）。出汗的副作用最多见，但常为轻度和可耐受。有4例患者服用匹罗卡品12个月，未发现任何严重副作用。由于干燥症状的临床改善率及副作用与美国和欧洲报道的相似，故我们采用盐酸匹罗卡品（9 mg/d）的治疗方案适合于日本干燥综合症患者。
附原文：We studied the efficacy of oral pilocarpine hydrochloride (9 mg/day, three times daily) on sicca symptoms in 21 patients with Sjögren's syndrome (SS) of the patients, 19 continued the treatment for at least one month, and subjective improvement of dry mouth and dry eye was observed in 10 patients (53%) and 5 patients (26%), respectively. As adverse effects, diaphoresis was most frequently recognized, but it was generally mild and tolerable. In the four patients who have been taking pilocarpine for 12 months, any severe side effects have not been observed. Since the incidences of clinical improvement of sicca symptoms and adverse effects were comparable with the other studies reported from US or Europe, our treatment protocol using pilocarpine hydrochloride (9 mg/day) was
considered as appropriate for Japanese SS patients.
引自：Takaya M, Ichikawa Y, Yamada C, Hoshina Y, Horiki T, Uchiyama M.Treatment with pilocarpine hydrochloride for sicca symptoms in Sjögren's syndrome. Ryumachi. 1997，37(3):453-7