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尼鲁米特Nilutamide

2009-10-24 15:23:31  作者:新特药房  来源:中国新特药网  浏览次数:224  文字大小:【】【】【
简介: 尼鲁米特Nilutamide 中文别名:尼鲁米特、尼鲁他胺 英文别名:Anandron、Nilandron 药品类别:促性激素类药 【英 文 名】 Nilutamide、Anandron【作用特点】 本品是非甾体抗雄激素受体药,对其它的 ...

 尼鲁米特
Nilutamide 
中文别名:尼鲁米特、尼鲁他胺
英文别名:Anandron、Nilandron   
药品类别:促性激素类药
【英 文 名】 Nilutamide、Anandron
【作用特点】 
本品是非甾体抗雄激素受体药,对其它的甾体受体如雌激素、孕激素、盐或糖皮质激素的受体均无作用,故无其它激素或抗激素的功能,本品在体内化学结构较少受代谢变化,对受体的作用较持久,如与手术或化学(用LHRH类似物)去势合用,可使外周抗雄激素作用更为完全,即可抑制去势后肾上腺皮质仍然分泌的雄激素的效应,并可抑制使用LHRH类似物如利普安后最初几天出现的睾丸酮增加、前列腺癌恶化现象。
【功能主治】适用于已转移的前列腺癌,可与手术或化学去势合用。
【用法用量】口服:应于去势(手术或化学方法)时开始给药,并持续使用,诱导剂量每日300mg。连服4周,维持剂量每日150mg,可1次或分多次服,如出现不良反应恃别是消化道反应,可缩短从诱导剂量到维持剂量的过渡时间。
【不良反应】少数患者出现黑暗中视力调节障碍及色觉障碍,停药后可消失,也可配戴有色眼镜以减轻症状;见戒酒硫样作用;肺间质综合征(用药应慎重);轻度转氨酶升高,继续用药时可好转,但可能同时发生溶细胞性肝炎;其它可见恶心、呕吐、阳痿、性欲减退、面部潮红等。
【注意事项】禁用于严重肝功能不全患者,当临床出现疑似肝炎的症状,如恶心、呕吐、腹痛、黄疸,应检查转氨酶,如超过正常上限3倍应中止给药。出现原因不明的呼吸困难或其症状加剧时,应做X线检查,如发现肺部间质性病变应立即停药。机动车或机器操作人员应注意其可能出现视物模糊作用。
【相互作用】本品可能作用于微粒体酶系统而降低肝脏对某些药物的代谢功能,如可使抗维生素K类、苯妥英、普萘洛尔、利眠宁、安定、茶碱等药物的消除减慢,而血药浓度可增加,这些药物或代谢途径类似的其它药物在与本品并用时应适当调整剂量。当与抗维生素K类并用时,应随时严密注意凝血功能(凝血酶原值),在以本品治疗时有时要减低抗维生素K类药物的用量。
【制剂规格】  片剂:50mg*30片/盒。
【贮藏】  遮光、密封、干燥处保存。

 NILANDRON TAB 150MG 30

 Nilutamide

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Brand names: Nilandron™

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Home > Library > Health > Drug InfoBrand names: Nilandron™

Chemical formula:
Drug Forms:
Nilutamide tablets (below)
Nilutamide Oral tablet
Español:
Tabletas de nilutamida
Nilutamida, Tableta oral
Nilutamide tablets
What are nilutamide tablets?
NILUTAMIDE (Nilandron(TM)) blocks the effect of the male hormone called testosterone. Prostate cancer responds to the removal of androgens. Nilutamide is used in combination with surgical treatment. Generic nilutamide tablets are not yet available.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
• alcoholism
• anemia
• liver disease
• lung disease
• visual problems
• an unusual or allergic reaction to nilutamide, other medicines, foods, dyes, or preservatives
• trying to conceive with your partner

How should I take this medicine?
Take nilutamide tablets by mouth at the same time each day. Follow the directions on the prescription label. Swallow the tablets with a drink of water. Do not take your medicine more often than directed. Finish the full course prescribed by your doctor or health care professional, even if the tablets make you feel unwell. Do not stop taking except on your prescriber's advice.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. If you vomit after taking a dose, call your prescriber or health care professional for advice.

What drug(s) may interact with nilutamide?

• ethanol
• phenytoin
• theophylline
• warfarin

Tell your prescriber or health care professional about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.


What should I watch for while taking nilutamide?

Visit your prescriber or health care professional for regular checks on your progress. At first your condition can get worse, but it will then improve as you continue your treatment. Improvement in your condition can take several days.

Nilutamide may affect your vision. If you notice a change in how your eyes adjust to the dark after starting nilutamide, do not drive at night or through tunnels. This side effect usually goes away. Wearing tinted glasses may help.

You should avoid alcohol while taking nilutamide. Mixing alcohol and nilutamide can cause more side effects.


What side effects may I notice from taking nilutamide?

Side effects that you should report to your prescriber or health care professional as soon as possible:
• difficulty breathing when exerting yourself
• chest pain
• fever
• persistent cough
• skin rash, hives, or itching
• swelling of the lips, tongue or face
• vomiting
• yellowing of the skin

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• constipation
• diarrhea
• dizziness
• hot flashes
• nausea
• vision disturbance (trouble adjusting to the dark)
Where can I keep my medicine?
Keep out of the reach of children in a container that small children cannot open.

Store between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Throw away any unused medicine after the expiration date.
Last updated:
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

责任编辑:admin


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