双氯芬酸钠（Voltaren服他宁1%胶凝）

药理药动：服他宁乳胶剂是一种外用消炎镇痛药，其活性物质含量相当于1%的双氯芬酸钠，通过揉擦很容易进入皮肤，并由于其含醇-水基质起到抚慰和清凉作用。动物实验研究表明，局部应用可使其活性成份穿透皮肤，聚集于皮下组织，抗御急慢性炎性反应。对因外伤或风湿病引起的炎症，本药的消炎镇痛特性可使炎性肿胀显著减轻，对触痛和活动性疼痛同样有效。 　　

适应症：
用于下列疾病的局部治疗 ：肌腱、韧带、肌肉和关节的创伤性炎症，例如 ：扭伤、劳损和挫伤。 　　
局限性软组织风湿病，例如 ：腱鞘炎、肩-手综合征和滑囊炎。 　　
局限性风湿性疾病，例如 ：四肢与脊柱的骨关节病，关节周围病变。 　　

用法用量：按需要治疗的痛处大小，施用2-4 g，并轻轻揉擦，每日3-4次。 　　

不良反应：偶可发生皮肤瘙痒、发红、刺痛、皮疹。个别病例可见光过敏反应，若大面积长期应用，不能完全排除引起全身副作用的可能性。 　　

禁忌症：对双氯芬酸、乙酰水杨酸和其它非甾体抗炎药及异丙醇或丙二醇过敏者。 　　

注意事项：本药只适用于无破损的皮肤表面，忌用于皮肤损伤或开放性创口处。禁止接触眼和粘膜，严禁口服。 　　

药品过量：如应用不当或误服(如儿童)而引起明显的全身性副作用时，通常可采用治疗非甾体抗炎药中毒的治疗措施。 　　
剂 型：乳胶剂

副作用：
⑴可以减轻关节疼痛，缓解症状，但不能解决根本问题，即只治标，不治本，因为这类药物不能控制病情发展。故非激素类抗炎药不可长期单独应用。 　　
⑵有较多药物副作用，如肝、肾功能损害，消化道溃疡和出血，血液、神经系统影响及股骨头坏死等。由非激素类抗炎药诱发的胃、十二指肠溃疡、出血或糜烂的患者中，大约50％没有症状，甚至有些老年人消化道出现了较大面积的溃疡也毫无疼痛的感觉，直到消化道出血才到医院看病；有的患者因长期服用非激素类抗炎药，最终导致肾功能衰竭而需透析治疗；也有因服用非激素类抗炎药使血小板急剧下降，导致脑出血而死亡的病例。所以这类药必须慎用。骨性关节炎本来没有生命危险，千万不要因用药不当而惹来杀身之祸 　　
⑶对软骨有不良影响。临床研究已经证明，非激素类抗炎药会抑制软骨的合成，还可直接破坏软骨细胞。而骨性关节炎的病变部位就在软骨。如果长期服用非激素类抗炎药，会对关节软骨产生破坏作用，从而加重骨性关节炎。使用非激素类抗炎药时间越长，剂量越大，关节软骨破坏就越严重。

Voltaren
Generic Name: diclofenac (dye KLOE fen ak)
Brand Names: Cataflam, Voltaren, Voltaren-XR, Zipsor

What is the most important information I should know about Voltaren?
This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use Voltaren. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking Voltaren. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to Voltaren (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.

Do not drink alcohol while taking Voltaren. Alcohol can increase the risk of stomach bleeding caused by Voltaren.

What is Voltaren?
Voltaren is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Voltaren works by reducing hormones that cause inflammation and pain in the body.

Voltaren is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis.

Voltaren may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking Voltaren?
Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Do not use this medication if you are allergic to Voltaren, or if you have a history of allergic reaction to aspirin or other NSAIDs.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take Voltaren:
a history of heart attack, stroke, or blood clot;
heart disease, congestive heart failure, high blood pressure;
a history of stomach ulcers or bleeding;
liver or kidney disease,
asthma;
polyps in your nose;
a bleeding or blood clotting disorder; or
if you smoke.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking Voltaren during the last 3 months of pregnancy may harm the unborn baby. Do not take Voltaren during pregnancy unless your doctor has told you to. Diclofenac can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medicine to a child without the advice of a doctor.

How should I take Voltaren?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

If you switch brands of Voltaren, your dose needs may change. Follow your doctors instructions about how much medicine to take.

Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time.

If you take Voltaren for a long period of time, your liver function may need to be checked with blood tests on a regular basis. Do not miss any scheduled visits to your doctor.

Store Voltaren at room temperature away from moisture and heat.

What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a Voltaren overdose may include nausea, vomiting, stomach pain, drowsiness, black or bloody stools, coughing up blood, shallow breathing, fainting, or coma.

What should I avoid while taking Voltaren?
Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to Voltaren (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.

Do not drink alcohol while taking Voltaren. Alcohol can increase the risk of stomach bleeding caused by Voltaren. Avoid prolonged exposure to sunlight. Voltaren may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

What are the possible side effects of Voltaren?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking Voltaren and seek medical attention or call your doctor at once if you have any of these serious side effects:
chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
swelling or rapid weight gain, urinating less than usual or not at all
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
bruising, severe tingling, numbness, pain, muscle weakness; or
neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions).

Less serious Voltaren side effects may include:
upset stomach, mild heartburn or stomach pain, diarrhea, constipation, bloating, gas;
dizziness, headache, nervousness;
skin itching or rash;
blurred vision; or
ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Voltaren?
Tell your doctor if you are taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking any of these drugs with Voltaren may cause you to bruise or bleed easily.

Before taking Voltaren, tell your doctor about all other medications you use, especially:
a blood thinner such as warfarin (Coumadin);
cyclosporine (Neoral, Sandimmune);
lithium (Eskalith, Lithobid);
methotrexate (Rheumatrex, Trexall);
diuretics (water pills) such as furosemide (Lasix).
steroids (prednisone and others);
aspirin or other NSAIDs such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others; or
an ACE inhibitor such as benazepril (Lotensin), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others.

This list is not complete and there may be other drugs that can interact with diclofenac. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?
Your pharmacist can provide more information about Voltaren.

What does my medication look like?
Diclofenac is available with a prescription under the brand names Cataflam and Voltaren. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Cataflam 50 mg round, biconvex, light-brown tablets
Voltaren 25 mg triangular, biconvex, yellow tablets
Voltaren 50 mg triangular, biconvex, light-brown tablets
Voltaren 75 mg triangular, biconvex, light-pink tablets
Voltaren XR 100 mg round, biconvex, light-pink, coated tablets

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

VOLTAREN（中文：双氯芬酸钠）

原产地英文药品名:
DICLOFENAC SODIUM
中文参考商品译名:
服他宁1%胶凝 100克/管 3管/盒
中文参考药品译名:
双氯芬酸钠
生产厂家中文参考译名:
诺华
生产厂家英文名: