英文药名：Norvasc(Amlodipine Besylate Tablets) 中文药名：络活喜（苯磺酸氨氯地平片) 生产厂家：辉瑞公司 药品简介 络活喜（苯磺酸氨氯地平片)属片剂。具有抗动脉粥样硬化作用，长期应用于冠心病患者可显著减少心血管事件。可以治疗高血压。 络活喜（Norvasc） 　　 络活喜（苯磺酸氨氯地平片）是截止目前为止世界处方量最大的治疗高血压的品牌药物。1990年以来，它在全球的使用已超过400亿个病人治疗日。该药品的成功得益于其杰出的疗效，起效和缓、作用持久平稳、每日一次的方便剂量、24小时稳定控制高血压和心绞痛以及极佳的安全性和耐受性。 　　 最新的临床研究结果显示，络活喜还具有抗动脉粥样硬化作用，长期应用于冠心病患者可显著减少心血管事件和操作的总和并显著减少冠心病相关的医疗费用。 别名：阿洛地平、络活喜 、氨氯地平、苯磺酸氨氯地平 　　 外文名：Amiodipine Besylate ,Istin, Norvasc 作用与用途 本品为钙离子拮抗剂，阻滞心肌和血管平滑肌细胞外钙离子经细胞膜的钙离子通道进入细胞。直接舒张血管平滑肌，具有抗高血压作用，本品缓解心绞痛是通过扩张外周小动脉，使外周阻力降低，从而降低心肌耗氧量，另外扩张正常和缺血区的冠状动脉及冠状小动脉，使冠状动脉痉挛病人的心肌供氧量增加。用于治疗高血压、稳定型心绞痛和缺血性心脏病。 用法与用量 治疗高血压和心绞痛的初始剂量为5mg，每日一次。根据患者的临床反应，可将剂量增加，最大可增至10mg，每日一次。 　　 本品与噻嗪类利尿剂，β-受体阻滞剂和血管紧张素转换酶抑制剂合用时不需调整剂量。 　　 通常口服起始剂量为5mg，每日一次，最大不超过10mg，每日一次。瘦小者、体质虚弱者、老年患者或肝功能受损者从2.5mg，每日一次开始用药；合用其它抗高血压药者也从此剂量开始用药。用药剂量根据个体需要进行调整，调整期应不少于7-14天，以便医生充分评估患者对该剂量的反应。但在临床有保障的前提下，可以加快调整速度。治疗心绞痛的推荐剂量是5-10mg，老年患者或肝功能受损者需减量。 Norvasc(Amlodipine Besylate) Description Norvasc controls high blood pressure for a full 24 hours and can be used to treat the chest pain of angina. NORVASC works to relax your cat's blood vessels, allowing blood to flow more easily through them. The end result is lower blood pressure and less angina which makes for a healthier kitty. NORVASC Rx Generic Name and Formulations: Amlodipine (as besylate) 2.5mg, 5mg, 10mg; tabs. Company: Pfizer Inc. Select therapeutic use: Angina Hypertension Indications for NORVASC: Vasospastic and chronic stable angina. Adult: 10mg once daily. Elderly or hepatic impairment: 5mg once daily. Children: Not recommended. Warnings/Precautions: Severe obstructive coronary disease. Severe aortic stenosis. CHF. Hepatic dysfunction. Pregnancy (Cat.C). Nursing mothers: not recommended. Interactions: May be potentiated by CYP3A inhibitors; monitor and may need to adjust dose. Concomitant CYP3A inducers; monitor BP. Concomitant sildenafil; monitor for hypotension. Concomitant simvastatin: limit simvastatin dose to 20mg/day. May potentiate cyclosporine or tacrolimus; monitor levels and adjust dose. Pharmacological Class: Calcium channel blocker (CCB) (dihydropyridine). Adverse Reactions: Edema, fatigue, palpitations, dizziness, nausea, flushing, abdominal pain, drowsiness. How Supplied: Tabs 2.5mg, 10mg—90; 5mg—90, 300 Indications for NORVASC: Hypertension. Adult: 5mg daily. Adjust at 7–14 day intervals; usual max 10mg daily. Small, fragile, elderly, hepatic impaired, patients on other antihypertensives: 2.5mg daily. Children: <6yrs: not established. 6–17yrs: 2.5–5mg daily. Warnings/Precautions: Severe obstructive coronary disease. Severe aortic stenosis. CHF. Hepatic dysfunction. Pregnancy (Cat.C). Nursing mothers: not recommended. Interactions: May be potentiated by CYP3A inhibitors; monitor and may need to adjust dose. Concomitant CYP3A inducers; monitor BP. Concomitant sildenafil; monitor for hypotension. Concomitant simvastatin: limit simvastatin dose to 20mg/day. May potentiate cyclosporine or tacrolimus; monitor levels and adjust dose. Pharmacological Class: Calcium channel blocker (CCB) (dihydropyridine). Adverse Reactions: Edema, fatigue, palpitations, dizziness, nausea, flushing, abdominal pain, drowsiness. How Supplied: Tabs 2.5mg, 10mg—90; 5mg—90, 300 ----------------------------------------- NORVASC TAB 5MG UD 100  AMLODIPINE BESYLATE     00069-1530-41 NORVASC TAB 5MG 90  AMLODIPINE BESYLATE     00069-1530-68 NORVASC TAB 2.5MG 90  AMLODIPINE BESYLATE     00069-1520-68 NORVASC TAB 10MG 90  AMLODIPINE BESYLATE     00069-1540-68