英文药名：Losarhyd Tablets LD（Losartan Potassium/Hydrochlorothiazide） 中文药名：氯沙坦钾/氢氯噻嗪配合錠LD 生产厂家：田边三菱制药 ロサルヒド配合錠LD「タナベ」 药品介绍 治疗类别名称 可持续发展ARB/利尿剂组合 上市日期：2014年6月 商標名 LOSARHYD Tablets LD 1. ロサルタンカリウム 一般名 ロサルタンカリウム（Losartan Potassium） 化学名 Monopotassium 5-{［4'-（2-butyl-4-chloro-5-hydroxymethyl-1H-imidazol-1-yl）methyl］biphenyl-2-yl}-1H-tetrazol-1-ide 分子式 C22H22ClKN6O 分子量 461.00 構造式 性状 是一种白色结晶粉末。 这是非常易溶于水，可溶于甲醇或乙醇（99.5）。 2. ヒドロクロロチアジド 一般名 ヒドロクロロチアジド（Hydrochlorothiazide） 化学名 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 分子式 C7H8ClN3O4S2 分子量 297.74 構造式 性状 白色结晶或结晶性粉末，无臭，味微苦。 它是易溶于丙酮，稍少溶于乙腈，极微溶于水或乙醇（95），并在乙醚中几乎不溶。 溶于氢氧化钠试剂。 熔点 约267℃（分解） 操作注意事项 稳定性测试 加速试验使用包被放置在PTP铝和结果的聚乙烯容器（干燥剂）（40℃，相对湿度75％，6个月），Rosaruhido组合片剂LD“田边”是在正常的市场分布5，其中据推测3年稳定）。 有效成分：氯沙坦钾  Losartan Potassium，氢氯噻嗪 Hydrochlorothiazide 药效药理 1.氯沙坦钾 结合选择性地AT1血管紧张素II受体的受体，它代表通过抑制血管紧张素II的生理作用的降血压作用。这种药物的主要代谢物的羧酸也显示相同的方式，为在该药物的效果。此外，缓激肽分解酶（激肽酶Ⅱ）不直接作用。 2.氢氯噻嗪 噻嗪类利尿剂。为了抑制Na+和氯离子的再吸收肾远曲小管，以促进水的排泄。此外，它有一个碳酸酐抑制作用。降血压作用是由于在初始循环血液流量减少，在长期据信由于末梢血管的扩张。 适应证： 治疗高血压 用法用量 成年人，每日口服一次，每次1片剂（12.5毫克/50毫克）口服给药。这种药物是不是要用作一线治疗高血压的治疗。 包装规格：（注：以下产品不同规格和不同价格，采购以咨询为准） 组合片LD 50mg/12.5mg 100片（10片×10）500片（10片×50）56片（14片×4）700片（14粒×50）500粒（瓶装） 制造厂商 田边三菱制药株式会社 完整处方资料附件： 1）：http://www.info.pmda.go.jp/go/pack/2149110F1252_1_07/ 2）：http://www.tanabe.co.jp/product/di/productdetail.php?id=6506 3）：http://www.tanabe.co.jp/product/di/files/tb/LOSD_a_tb_029912.html Losarhyd Tablets LD（Losartan Potassium/Hydrochlorothiazide）ロサルヒド配合錠LD「タナベ」 Effects of this medicine This medicine has angiotensin II receptor antagonistic activity and promotional action of sodium excretion to decrease blood pressure. It is usually used to treat hypertension. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you have liver dysfunction, anuria, acute renal failure or diabetes mellitus. If you are patient whose amount of sodium and potassium in the fluid has been definitely decreased. If you are on dialysis. •If you are pregnant, possibly pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •In general, for adults, take 1 tablet at a time, once a day. Strictly follow the instructions. •If you miss a dose, take a dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time. •If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist. •Do not stop taking this medicine unless your doctor instructs you to do so. Precautions while taking this medicine •This medicine may cause dizziness/light headedness due to its hypotensive action. Be aware of operating in potentially hazardous activities such as driving a car and working at heights. •Intake of alcohol may enhance the effect of this medicine. Refrain from drinking alcohol while taking this medicine. Possible adverse reactions to this medicine The most commonly reported adverse reactions include dizziness, frequent urination and headache. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. •discomfort, oral discomfort, sweating[anaphylaxis] •swelling of face/lip/throat/tongue[angioedema] •loss of appetite, general malaise, nausea/vomiting[acute hepatitis, fulminant hepatitis] •decreased urine output, edema of limbs/face, general malaise[acute renal failure] •coldness, vomiting, loss of consciousness[shock, faint, loss of consciousness] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •Keep out of the reach of children. Store away from direct sunlight, heat and moisture. •Discard the remainder. Do not store them.