英文药名：Losartan K Tab(Losartan Potassium) 

中文药名：氯沙坦钾片

适合病症：高血压症

生产厂家：科研制药

ロサルタンＫ錠２５ｍｇ「科研」

治疗类别名称
A-II拮抗剂
欧文商標名
LOSARTAN K Tab.25mg
一般名：
ロサルタンカリウム (Losartan Potassium)
化学名：
Monopotassium 5-{[4'-(2-butyl-4-chloro-5-hydroxymethyl-1H -imidazol-1-yl)methyl]biphenyl-2-yl}-1H -tetrazol-1-ide
構造式：

分子式：
C22H22ClKN6O
分子量：
461.00
性状：
本品是一种白色结晶粉末。
它是易溶于水，可溶于甲醇或乙醇（99.5）。
药效与药理
氯沙坦钾主要转化成羧酸，该羧酸是在肝脏中的主要代谢物。
结合选择性地AT1血管紧张素II受体的受体，它代表通过抑制血管紧张素II的生理作用的降血压作用。这种药物的主要代谢物的羧酸也显示相同的方式，为在该药物的效果。此外，缓激肽分解酶（激肽酶Ⅱ）不直接作用。
适应病症
高血压
2型糖尿病患者、糖尿病肾病与高血压和蛋白尿有关
用法与用量
高血压：
成年人；每天一次，每次口服25-50毫克。此外，年龄，将根据症状来调节，它可以增加1天100毫克。
2型糖尿病患者、糖尿病肾病与高血压和蛋白尿有关
成年人，每天给药一次，每次口服50毫克。此外，看血压值增加1天100毫克。然而，在例如患者可能导致过度的血压降低，从25毫克开始使用。
包装规格
25毫克/片

生产厂家：科研制药
LOSARTAN K Tab.25mg(Losartan potassium)
Brand name : LOSARTAN K Tablets 25mg "KAKEN"
　Active ingredient: Losartan potassium
　Dosage form: white tablet, diameter: 6.1mm, thickness: 2.8mm
　Print on wrapping: ロサルタンK錠25mg「科研」, LOSARTAN K Tab.25mg 「KAKEN」, 25mg, DK506
Effects of this medicine
This medicine decreases blood pressure with angiotensin II-receptor antagonistic activity. It also reduces the deterioration of the renal function by reducing proteinurina to protect the kidneys.
It is usually used in the treatment of hypertension, and diabetic nephropathy in the type 2 diabetes mellitus accompanied by hypertension and proteinuria.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have a history of hepatic or renal disorder, or cerebrovascular disorder (cerebral stroke etc.).
•If you are pregnant, possibly pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•For hypertension: In general, for adults, take 1 to 2 tablets (25 to 50 mg of the active ingredient) at a time, once a day. The dosage may be adjusted according to your age or symptoms, or may be increased up to 4 tablets (100 mg of the active ingredient) a day.
For diabetic nephropathy*: In general, for adults, take 2 tablets (50 mg of the active ingredient) at a time, once a day. The dosage may be increased up to 4 tablets (100 mg of the active ingredient) a day according to the blood pressure level. If you have the potential to develop excessive hypotension, the initial dose is started at 1 tablet (25 mg of the active ingredient).
In any cases, strictly follow the instructions.
•If you miss a dose, take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
*: diabetic nephropathy in the type 2 diabetes mellitus accompanied by hypertension and proteinuria.
Precautions while taking this medicine
•Dizziness and light-headedness may occur due to an excessive decrease in blood pressure. Therefore, be aware of driving a car, working at heights, or operating dangerous machinery.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include headache, dizziness, vomiting, nausea, hot flush, hyperkalemia, hypotension, asthenia and fatigue. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•hives, breathing difficulty, edema [anaphylaxis]
•swelling of the face, lips, tongue, or throat [angioedema]
•decreased urine output, generalized edema [renal failure]
•cold sweat, nausea, loss of consciousness [shock, faint, unconsciousness]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them
Kaken Pharmacetical Co.,LtdInternal
Revised: 8/2012
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.