英文药名: CAPTORIL-R CAPSULES(Captopril)

中文药名: 卡托普利-R胶囊

生产厂家: 第一三共

カプトリル－Ｒカプセル１８．７５ｍｇ

治疗类别名称
肾素 - 血管紧张素系统的抗高血压
持效性制剂
商標名
CAPTORIL-R CAPSULES
一般名
カプトプリル(Captopril)
化学名
(2S )-1-[(2S )-2-Methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
分子式
C9H15NO3S
分子量
217.29
構造式

性状
它是一种白色晶体或结晶粉末。
非常易溶于甲醇，易溶于乙醇（99.5），微溶于水。
分配系数
见表分配系数
活性成分的物理化学知识的表
分配系数

pH	2.0	3.0	4.0	7.4
分配係数(log Pow)	-0.72	-0.77	-1.52	-2.00

POW=（正辛醇相卡托普利浓度/水相的卡托普利浓度）
适应病症
原发性高血压，肾性高血压
用法用量
成人；每日二次，每次口服一次1-2粒/胶囊（37.5-75毫克），此外，增加或减少取决于患者的年龄和症状。然而，一旦在患有严重高血压和肾性高血压一个胶囊，开始从一天给药两次（18.75-37.5mg）。
药效药理
卡托普利是通过降低总外周血管阻力来抑制血管紧张素转换酶，通过抑制生产血管紧张素II，以展开末梢血管，随着降血压作用的代表，减少醛甾酮的分泌，轻度钠排泄作用。
(1) 卡托普利可竞争性地抑制来自兔肺纯化血管紧张素转换酶并且还抑制引起血管紧张素I通过口服血压的增加。
(2) 降压作用
1) 卡托普利通过口服给药，但以降低自发性高血压大鼠和肾血管性高血压大鼠的血压，不影响正常大鼠的血压。
2) 引起耐化学性的降压效果也卡托普利（大鼠）的长期连续口服给药。连续给药后也血压其余和仅返回到原来的电平，回弹现象是没有看到（鼠）。
3) 卡托普利导致血压降低和增加响应于剂量的心输出量，但降低了总外周阻力，显著心脏速率的变化没有观察到。也不可能减少即使在降血压，显著增加肾，脑血流以相反（大鼠）时的器官的血流。
4) 卡托普利改善了心脏肥大由于通过长期给药高血压，导致延长生命效果（鼠）。
(3) 对血压昼夜节律变化的影响
患者高血压，卡托普利-R，当每天一次一个胶囊，最大降压作用后4小时的剂量，作用持续时间，观察到10至12小时后施用。此外，最大值，与标准差和血压的每日最大变动幅度最小血压显著降压效果低。
包装规格
胶囊：18.75mg
（PTP） 100胶囊  1000粒胶囊

（瓶）  500胶囊
制造厂商
第一三共有限公司Esufa

完整处方资料附件：http://www.info.pmda.go.jp/go/pack/2144001N1059_3_05/
CAPTORIL-R CAPSULES（Captopril）
Brand name : CAPTORIL-R CAPSULES 18.75mg
　Active ingredient: Captopril
　Dosage form: white capsule with reddish brown belt, major axis : 15.8 mm, minor axis : 5.8 mm
　Print on wrapping: (front) カプトリル-Rカプセル18.75mg, 第一三共エスファ, カプトリル-R, 18.75mg, 271, (back) CAPTORIL-R 18.75mg, 血圧降下薬, カプトリル-R, 18.75mg
Effects of this medicine
This medicine inhibits angiotensin-converting enzyme to suppress production of angiotensin II, and consequently shows antihypertensive action by dilating peripheral blood vessels and decreasing vascular resistance. It also suppresses secretion of aldosterone to show sodium excretory effect.
It is usually used in the treatment of essential hypertension and renal hypertension.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have a history with angioedema.
If you are receiving apheresis or hemodialysis.
•If you are pregnant, possibly pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adults, take 1 to 2 capsules (18.75 to 37.5 mg of the active ingredient) at a time, twice daily. The dosage may be adjusted according to the diseases, age or symptoms. In the treatment of severe essential hypertension and renal hypertension, it is desirable to start taking 1 capsule (18.75 mg) at a time, once or twice daily. Strictly follow the instructions.
•If you miss a dose, take a dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•Dizziness and lightheadedness may occur due to decreased blood pressure. Pay attention to performing dangerous operations such as driving a car or working at heights.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include cough, rash, itch, hives, photosensitivity, anemia, taste abnormality and jaundice. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•respiratory distress; swelling in the face, tongue, glottis or larynx; hives [angioedema]
•general malaise, headache, throat pain, gum bleeding, subcutaneous bleeding [pancytopenia, agranulocytosis]
•decreased urine output, edema, loss of appetite [acute renal failure, nephrotic syndrome]
•numbness in the limbs and lips, muscular weakness, paralysis in the limbs [hyperkalemia]
•blisters appearing on the skin, severe itchiness throughout the body [pemphigus like symptoms]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them.
DAIICHI SANKYO ESPHA CO., LTD.Internal
Revised: 3/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.