英文药名：CALSLOT TABLETS（Manidipine Hydrochloride）

中文药名：盐酸马尼地平片

生产厂家：武田薬品

カルスロット錠5／カルスロット錠10／カルスロット錠20

治疗类别名称
持续钙拮抗剂降压
商標名
CALSLOT TABLETS
化学構造式

一般名
マニジピン塩酸塩（Manidipine Hydrochloride）〔JAN〕
化学名
3-{2-［4-（Diphenylmethyl）piperazin-1-yl］ethyl}5-methyl（4RS）-2,6-dimethyl-4-（3-nitrophenyl）-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
分子式
C35H38N4O6・2HCl
分子量
683.62
融点
約207℃（分解）
性状
马尼地平盐酸盐是一种白色结晶或结晶粉末微黄。易溶于二甲基亚砜，难溶于甲醇，乙醇（99.5）微溶，并且几乎不溶于水。二甲亚砜溶液（1→100）示出了没有旋光性。成为光线稍微乐队褐白色。
适应病症
高血压症
用法用量
成人每天口服一次，每次10-20毫克口服给药。然而，开始从每天5毫克的使用，根据需要逐渐增加。
另一个成人每日剂量和配方如下。
◇马尼地平片 5
每天一次两到四个片，早餐口服后
◇马尼地平片 10
每天一次一到两片，早餐后口服
◇马尼地平片 20
每天一次1/2到1片，口服后早餐
药效药理
1. 降圧作用机序
本剂的抗高血压作用是通过作用于膜电位依赖性钙通道的主要血管平滑肌抑制Ca 2+内流，放松血管平滑肌被认为是由延伸在容器来实现。
(1) 结合受体
[3H]在大鼠心脏肌肉膜标本 - 尼群地平与受体的结合，以显着抑制，该抑制效果，甚至在试样清洗之后仍然存在（体外）。
这被推定为具有由于在膜电位依赖性钙通道具有更高的亲和力与受体。
(2) 钙拮抗作用
关于在Ieusagihai动脉标本的钙离子电流的选择性和持久性的抑制效果，另外，以抑制流入到45Ca2+在兔主动脉标本的细胞（体外）。这表明，具有效果，从方框钙通道。
(3) 对心脏和血管的影响
对于高血压患者（成人）心脏血流动力学，已经显著减少只是总外周血管阻力，这被认为是一个主要的降压机构，另一方面，对心功能的影响不大。
2. 降圧作用
(1) 在高血压患者（成人），并在血压显著降低血压昼夜波动测试在任何通过口服每日一次测量甚至观察到的，它表明，可以得到全天稳定降压效果。
(2) 患者24小时血压监测检测高血压（成人），但通过一天一次已经观察口服24小时持续降压效果，降压级夜间小。
3. 对肾血流动力学的影响
以高血压患者肾循环（成人），降低肾血管阻力，增加显著温和而降解，尽管肾血流量和肾灌注压的肾小球滤过率。
包装规格
片剂
5mg：100片（10片×10），500片（10片×50）

10mg：100片（10片×10），500粒（瓶装，10片×50），700片（14片×50）

20mg：100片（10片×10），500片（10片×50），700片（14片×50）

制造厂商
武田化学工业有限公司
完整处方资料附件：http://www.info.pmda.go.jp/go/pack/2149027F1020_1_09/
CALSLOT TABLETS（Manidipine hydrochloride）
CALSLOT TABLETS 5（カルスロット錠5）
Brand name : CALSLOT TABLETS 5
　Active ingredient: Manidipine hydrochloride
　Dosage form: yellowish white tablets, φ7.1 mm, thickness 2.8 mm
　Print on wrapping: (Face) 230 5, (Back) カルスロット5
CALSLOT TABLETS 10（カルスロット錠10）
Brand name : CALSLOT TABLETS 10
　Active ingredient: Manidipine hydrochloride
　Dosage form: light yellow tablets, φ7.6 mm, thickness 3.1 mm
　Print on wrapping: (Face) 230 10, (Back) カルスロット10
CALSLOT TABLETS 20（カルスロット錠20）
Brand name : CALSLOT TABLETS 20
　Active ingredient: Manidipine hydrochloride
　Dosage form: light orange-yellow tablets, φ8.1 mm, thickness 3.2 mm
　Print on wrapping: (Face) 230 20, (Back) カルスロット20
Effects of this medicine
This medicine reduces blood pressure by relaxing and dilating blood vessels through its action on the calcium channel of vascular smooth muscle.
Usually, used for treatment of hypertension.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you have hepatic disorder.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•General dosage regimen: For adults, take 2 to 4 tablets (10 to 20 mg of the active ingredient) at a time, once a day, after breakfast. Start taking 1 tablet (5 mg) a day and the dosage will then be increased as needed. Strictly follow the instructions of your doctor/pharmacist.
•If you missed a dose, take the missed dose as soon as possible if you noticed it within that day. If you noticed it at night, skip the missed dose and then go back to your regular dosing schedule, beginning after breakfast. DO NOT take double doses to make up for the missed dose.
•If you took too much of the medicine (more than ordered), check with your doctor/pharmacist.
•Do not stop taking the medicine without the instructions of your doctor.
Precautions while taking this medicine
•As dizziness and light-headedness may appear due to excessive lowering of blood pressure, take extra care when working at heights or operating dangerous machinery such as driving a car.
•Do not take the medicine together with grapefruits juice.
Possible adverse reactions to this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: rash, itching, hot flush, heat sensation, palpitation, tachycardia, dizziness, dizziness on standing up, headache, dull headache, nausea, vomiting, loss of appetite, abdominal discomfort, heart burn, abdominal pain, enlarged feeling of abdomen, constipation, dry mouth, general malaise, lassitude, edema, frequent urination, photosensitivity, gingival hyperplasia, chylous ascites in renal failure patients, gynecomastia, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•dizziness on standing up, dullness, twilight state [transient loss of consciousness due to excessive falloff blood pressure]
•one-sided paralysis of hands/feet and face, impaired speech/visual disturbance, headache, disturbance of consciousness [cerebral infarction]
•fever, throat pain, dullness, nose bleeding/subcutaneous hemorrhage [agranulocytosis/thrombocytopenia]
•chest discomfort, palpitation, chest pain [ventricular extrasystoles, supraventricular extrasystoles]
•generalized red rash, skin exfoliation, fever  [erythroderma]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and humidity.
•Discard the remainder. Do not store them. If you dispose of unused medicines, seek advice of your pharmacist about proper disposal of drugs.
Takeda Chemical Industries, Ltd.Internal
Revised: 11/2007
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.