|
英文药名：NEUER(Cetraxate Hydrochloride CAPSULES/FINE GRANULES 40%)
中文药名：盐酸西曲酸酯胶囊/細粒40%
生产厂家：第一三共制药
ノイエルカプセル２００ｍｇ／ノイエル細粒４０％
治疗类别名称
粘膜防御性胃炎，胃溃疡治疗剂
商標名
NEUER CAPSULES
一般名
セトラキサート塩酸塩(Cetraxate Hydrochloride)
化学名
3-｛4-［trans -4-(Aminomethyl)cyclohexylcarbonyloxy］-phenyl｝propanoic acid monohydrochloride
分子式
C17H23NO4・HCl
分子量
341.83
構造式
性状
它是一种白色晶体或结晶粉末。微溶于甲醇，微溶于水或乙醇（95），并在乙醚中几乎不溶。
熔点
约236℃（分解）
药效药理
本剂是提高胃粘膜微循环障碍，胃粘膜中的前列腺素E2，I2生物合成增加作用的主要动作，与所谓细胞保护性（细胞保护）作用沿，如保持和合成促进胃粘膜粘液的作用，在粘膜是一种药物，以固化胃粘膜损伤激活抑制和抑制胃蛋白酶的产生，已经联合抑制的攻击系统因子抑制作用，例如通过抗激肽释放酶作用的胃液分泌，通过作用于防御攻击因子的在两侧。
(1) 对各种实验胃黏膜病变行动
幽门结扎，应力，乙醇，阿司匹林，消炎痛，保泰松，羟色胺，血清素 - 牛磺胆（胆汁盐）的大鼠实验性急性胃炎，在大鼠实验突然或慢性胃炎，乙酸等造成的，致癌剂MNNG胃溃疡，已经认识到预防和治疗效果在大鼠实验慢性溃疡如夹紧可的松。
(2) 胃黏膜微循环的改善作用
增加大鼠和狗胃粘膜血流量），也打压减少，改善大鼠胃黏膜病变疾病模型（幽门结扎，压力，吲哚美辛，羟色胺可见胃粘膜微循环异常）已经观察到。
此外，该动作增加胃粘膜血流量也已在胃溃疡患者的溃疡边缘观察到。
(3) 在前列腺素E2，I2的合成增加动作胃黏膜
老鼠前列腺素E2,6-酮胃黏膜 - 表现出作用的前列腺素F1α的增加。据信这是增加前列腺素E2，I2的合成。
(4) 胃粘膜粘液保持-合成促进作用
胃粘膜损伤疾病模型来抑制粘液在还原（乙醇，阿司匹林，低氧血症，燃烧压力，冷束缚应激，消炎痛），作为粘液成分，己糖胺，唾液酸，如糖蛋白的维护它接受。这些影响被认为是基于促进粘液合成的。
(5) 激活抑制粘膜作用在胃蛋白酶原
抑制大鼠阿司匹林给药时，可看到黏膜胃蛋白酶原的活化，已经发现抑制胃粘膜的自身消化。此外，已经观察到抑制看到的解扩展的反向扩散在（反扩散）氢离子和牛磺胆（胆汁盐）在给药后的粘膜损伤观察氢离子。
(6) 通过反激肽释放酶作用胃液分泌抑制作用
拮抗激肽释放酶，已经发现抑制胃酸的大鼠的分泌，胃蛋白酶。
适应病症
○胃粘膜病变（糜烂，出血，发红，肿胀）改善急性胃炎，慢性胃炎急性发作
○胃溃疡
用法及び用量
餐前和三至四次，成人每天一次，每次口服200毫克（1胶囊或颗粒剂0.5克）。
应当指出的是，增加或减少取决于患者的年龄和症状。
包装规格
胶囊:200毫克
（瓶）1,000cap。
（PTP）100cap。500cap。1000cap。2,100cap（21cap。×100）
細粒40％
（H.S.）0.5克×1200（6連包）
0.5克×2400（6連包）
0.5克×2520（3連包）
（瓶）100克 1公斤
制造厂商
第一三共有限公司Esufa
Cetraxate hydrochloride（NEUER CAPSULES/FINE GRANULES 40%）
NEUER CAPSULES 200mg（ノイエルカプセル200mg）
Brand name : NEUER CAPSULES 200mg
Active ingredient: Cetraxate hydrochloride
Dosage form: capsule (blue cap, white body), major axis: 17.8mm
Print on wrapping: (front) ノイエルカプセル200mg, 第一三共エスファ, NE, 200mg, (back)NEUER 200mg, 消化性潰瘍用薬, ノイエルカプセル, 200mg, D407, NE
NEUER FINE GRANULES 40%（ノイエル細粒40％）
Brand name : NEUER FINE GRANULES 40%
Active ingredient: Cetraxate hydrochloride
Dosage form: white to slightly yellow fine granules
Print on wrapping: 200mg/包(0.5g), ノイエル細粒40%, 0.5g
Effects of this medicine
This medicine improves gastric mucosal microcirculation as a principal action. It improves gastric mucosal lesion (erosion, bleeding, redness, and edema) by acting both on cytoprotection (protection) and inhibitory action against aggressive factors.
It is usually used to improve gastric mucosal lesion in acute gastritis or acute exacerbation of chronic gastritis and to treat gastric ulcer.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is << to be written by a healthcare professional>>
•In general, for adults, take 1 capsule (200 mg of the active ingredient) at a time, 3 to 4 times daily, after meal and before going to bed. The dosage may be adjusted according to the diseases, age or symptoms. Strictly follow the instructions.
•If you miss a dose, take a dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
The most commonly reported adverse reactions include constipation, rash, nausea, vomiting, dry mouth and diarrhea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep the medicine out of the reach of children. Store it away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them.
DAIICHI SANKYO ESPHA CO., LTD.Internal
Revised: 3/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://www.info.pmda.go.jp/go/pack/2329004C1129_3_02/
|
