英文药名:AIMIX Combination Tablets LD/HD(Irbesartan/Amlodipine Besilate)
中文药名:厄贝沙坦/氨氯地平斯汀配合錠LD/HD
生产厂家:盐野义制药 治疗类别名称 长效ARB/持续钙拮抗剂配方 商标名 AIMIX Combination Tablets LD AIMIX Combination Tablets HD 一般名 イルベサルタン(Irbesartan) 化学名 2-Butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one 構造式
分子式 C25H28N6O 分子量 428.53 性状 它是一种白色结晶粉末。易溶于二甲基亚砜,难溶于甲醇,乙醇(99.5)微溶,并且几乎不溶于水。溶于稀氢氧化钠TS中。 熔点 182.4-184.6℃ 分配系数 约10.1(pH7.4,1-辛醇/缓冲) 一般名 アムロジピンベシル酸塩(Amlodipine Besilate) 化学名 3-Ethyl 5-methyl(4RS)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl- 1,4-dihydropyridine-3,5-dicarboxylate monobenzenesulfonate 構造式
分子式 C20H25ClN2O5・C6H6O3S 分子量 567.05 性状 白色至微黄色色结晶性粉末。易溶于甲醇,微溶于乙醇(99.5),微溶于水。甲醇溶液(1→100)示出了没有旋光性。 熔点 约198℃(分解) 适应病症 高血圧症 用法用量 成人每天一次在(为100毫克/5毫克或100毫克/10毫克)口服给药。本品为一线治疗高血压的治疗。 药效药理 厄贝沙坦氢氯噻嗪复合制剂中的氢氯噻嗪可引起交感神经系统和肾素-血管紧张素系统激活,对抗降压作用,并降低血钾水平。而厄贝沙坦能够抵消由利尿剂诱发的代偿机制,从而加强利尿剂的降压效果,同时还能选择性阻断AT1亚型受体发挥降压作用。 另外,厄贝沙坦能够减弱氢氯噻嗪诱发的血清尿酸升高和血钾降低。厄贝沙坦氢氯噻嗪(r)能有效降低轻、中或重度高血压病人的血压,降低程度与ACEI、β阻滞剂和钙拮抗剂等单独或联合使用氢氯噻嗪相当。厄贝沙坦和氢氯噻嗪联用较单用所增加的疗效对达到治疗指南(JNC7和WHO/ISH)的目标血压十分重要。此外,长期使用厄贝沙坦氢氯噻嗪(r)的耐受性以及每天1片的简单用药方法可能对病人坚持治疗有所帮助。因此,厄贝沙坦氢氯噻嗪(r)对于为降低血压而必须联合用药的病人是合理选择。 生产商 日本盐野义制药
AIMIX Combination Tablets LD/HD(Irbesartan/Amlodipine Besilate) AIMIX® Combination Tablets LD/HD have a 24-hour-lasting antihypertensive effect and are a combination product of irbesartan (brand name: AVAPRO®), a long-acting ARB (angiotensin II receptor antagonist) and amlodipine besilate (brand name: AMLODIN®), a calcium antagonist with a strong, sustained hypotensive effect. DSP developed these products and submitted an application for manufacturing and marketing approval in November 2011. Clinical trials in Japan demonstrated the efficacy of AIMIX® Combination Tablets LD/HD in patients with hypertension uncontrolled by usual doses of irbesartan or amlodipine besilate alone. “AIMIX® Combination Tablets LD” is a combination of irbesartan 100mg/ amlodipine 5mg and “AIMIX® Combination Tablets HD” is a combination of irbesartan 100mg/amlodipine 10mg. AIMIX® Combination Tablets HD is the first combination product in Japan including 10mg of amlodipine. In June, 2012, DSP and Shionogi & Co., Ltd. (Shionogi, Headquarters: Osaka; President &CEO: Isao Teshirogi, Ph.D.) entered into a license agreement for the co-marketing in Japan of AIMIX® Combination Tablets LD/HD. Both companies plan to launch AIMIX® Combination Tablets LD/HD after they are listed on the national health insurance drug price standard. By promoting activities to provide information to medical institutions in parallel with Shionogi, DSP aims to provide AIMIX® Combination Tablets LD/HD to as many patients as possible with hypertension in Japan, further contributing to therapy for hypertension. Profile of “AIMIX® Combination Tablets LD/HD” [Product Name] AIMIX® Combination Tablets LD AIMIX® Combination Tablets HD [Generic Name]irbesartan/amlodipine besilate [Content/Description] AIMIX® Combination Tablets LD: Pale yellow film-coated tablets containing 100mg of irbesartan and 5mg of amlodipine (6.93mg of amlodipine besilate)per tablet. AIMIX® Combination Tablets HD: Pale yellow film-coated tablets containing 100mg of irbesartan and 10mg of amlodipine (13.87mg of amlodipine besilate) per tablet. [Indication] Hypertension [Dose and Administration] The usual recommended adult dose is one tablet (100mg/5mg or 100mg/10mg of irbesartan/amlodipine) once daily. AIMIX® Combination Tablets should not be used as a first-line treatment for hypertension http://meds.qlifepro.com/detail/622199201/irbesartan -------------------------------------------------------- 产地国家:日本 原产地英文商品名: AIMIX Combination(アイミクス配合錠HD 100mg/10mg)/tablets 100tablets 原产地英文药品名: Irbesartan/Amlodipine Besilate 中文参考商品译名: AIMIX(アイミクス配合錠HD 100毫克/10毫克)100片/盒 中文参考药品译名: 厄贝沙坦/氨氯地平斯汀 生产厂家中文参考译名: 盐野义制药 生产厂家英文名: Shionogi
------------------------------------------------------- 产地国家:日本 原产地英文商品名: AIMIX Combination(アイミクス配合錠LD 100mg/5mg)100tablets 原产地英文药品名: Irbesartan/Amlodipine Besilate 中文参考商品译名: AIMIX(アイミクス配合錠LD 100毫克/5毫克)100片/盒 中文参考药品译名: 厄贝沙坦/氨氯地平斯汀 生产厂家中文参考译名: 盐野义制药 生产厂家英文名: Shionogi
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