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当前位置:药品说明书与价格首页 >> 皮肤性病 >> 艾滋病 >> 药品推荐 >> Triumeq Combination Tablets(Dolutegravir钠/硫酸阿巴卡韦/拉米夫定)

Triumeq Combination Tablets(Dolutegravir钠/硫酸阿巴卡韦/拉米夫定)

2016-03-13 06:51:27  作者:新特药房  来源:互联网  浏览次数:4  文字大小:【】【】【
简介: 英文名称:Triumeq Combination Tablets(Dolutegravir Sodium/Abacavir Sulfate/Lamivudine) 中文药名:Dolutegravir钠/硫酸阿巴卡韦/拉米夫定组合片 生产厂家:葛兰素史克/ViiV Healthcare Co ...

英文名称:Triumeq Combination Tablets(Dolutegravir Sodium/Abacavir Sulfate/Lamivudine)

中文药名:Dolutegravir钠/硫酸阿巴卡韦/拉米夫定组合片

生产厂家:葛兰素史克/ViiV Healthcare Co

トリーメク配合錠

治疗类别名称
抗病毒化疗药物
商標名
Triumeq Combination Tablets
一般名
ドルテグラビルナトリウム(Dolutegravir Sodium)
化学名
Monosodium(4R,12aS)-9-{[(2,4-difluorophenyl)methyl]carbamoyl}-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-7-olate
分子式
C20H18F2N3NaO5
分子量
441.36
構造式

性状
白色至淡黄白色粉末。微溶于水,并在乙醇(99.5)几乎不溶。
熔点
1型晶体在分解的同时溶解在350℃左右。
分配系数
2.16±0.01(23℃)
一般名
アバカビル硫酸塩(Abacavir Sulfate)
化学名
(-)-{(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopenta-2-enyl}methanol hemisulfate
分子式
(C14H18N6O)2?H2SO4
分子量
670.74
構造式


性状
白色至淡黄色粉末。易溶于三氟乙酸,微溶于水,甲醇和乙醇(95)微溶。在0.1mol/ L盐酸试液可溶性和稀氢氧化钠的TS。
熔点
约219℃(分解)
分配系数(log P)
1.20(pH7.1?7.3,1-辛醇/水)
一般名
ラミブジン(Lamivudine)
化学名
(-)-1-[(2R,5S)-2-hydroxymethyl-1,3-oxathiolan-5-yl]cytosine
分子式
C8H11N3O3S
分子量
229.26
構造式

性状
白色至浅黄色结晶性粉末。易溶于二甲基亚砜,微溶于水,微溶于甲醇或乙醇(99.5),并在乙醚中几乎不溶。
熔点
关于176℃
分配系数
-0.9(1-辛醇/水系统)
組成
成分・含量

在一片含有52.6mg(50毫克为Dorutegurabiru),(600毫克为阿巴卡韦)硫酸阿巴卡韦702mg,含300毫克拉米夫定。
作用机理
TRIUMEQ是HIV-1的抗病毒药物[见微生物学]。
适应病症
感染艾滋病毒
用法用量
成人:每日给药一片,每次50毫克/300毫克/600毫克/片。
包装规格
口服片
(50毫克+600毫克+300毫克)/片*30片/瓶


制造厂商
ViiV Healthcare Co[联盟]葛兰素史克公司
注:以上中文资料信息仅供参考,使用以原处方为准:
1):http://www.info.pmda.go.jp/go/pack/6250106F1021_1_03/
2):https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2997739a-aa91-42aa-a206-a70e2db7b84f
新一代抗HIV三合一复方药物:Triumeq Combination Tablets(Dolutegravir Sodium/Abacavir Sulfate/Lamivudine)
Triumeq Combination Tablets(トリーメク配合錠)
 
Brand name : Triumeq Combination Tablets
 Active ingredient: Dolutegravir sodium
 Abacavir sulfate
 Lamivudine
 Dosage form: purple tablet, major axis: about 22 mm, minor axis: about 11 mm, thickness: about 7.6 mm
 Print on wrapping: 
Effects of this medicine
This medicine inhibits integrase of human immunodeficiency virus (HIV) and activities of HIV-1 reverse transcriptase to exert its antiviral effect.
It is usually used to treat HIV infection.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have liver disorder or have previously experienced pancreatitis.
If you have hepatitis B or C viral infection.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adults, take 1 tablet at a time, once a day, with or without food. Strictly follow the instructions.
•If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•Always carry a Hypersensitivity Reactions Warning Card.
•This medicine is not for the radical cure of HIV infection. Even if you continue taking this medicine, HIV infection may progress. Tell your doctor about all changes, if any, which have occurred in your physical condition.
•Pay attention that Saint John's wort may lower your blood level of this medicine.
•Iron preparations or dietary supplements containing calcium interfere with the absorption of this medicine. If you take iron preparations or dietary supplements containing calcium separately from food, take this medicine either 2 hours before or 6 hours after taking them.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include nausea, insomnia, headache and dizziness. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•fever, diarrhea, eruption [hypersensitivity]
•rash, fever, swollen lymph node [drug-induced hypersensitivity syndrome]
•fever, bloodshot eyes, facial swelling [toxic epidermal necrolysis, muco-cutaneo-ocular syndrome, erythema multiforme]
•persistent fever, bleeding tendency, prolonged bleeding [serious blood disorder]
•severe upper abdominal pain, low back pain, fever [pancreatitis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them. Seek advice of your pharmacy or medical institution about proper disposal of the unused medicines.
ViiV Healthcare K.K.Internal
Published: 6/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.

责任编辑:admin


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