英文药名:DENOTAS CHEWABLE COMBINATION TABLETS（Precipitated Calcium Carbonate/Cholecalciferol/Magnesium Carbonate）

中文药名:碳酸钙/胆钙化醇/碳酸镁咀嚼组合片

生产厂家:第一三共有限公司
治疗类别名称
钙/天然型维生素D3/镁制剂
組成
一片剂含有下列成分
有効成分
沉淀碳酸钙（日本药典）762.5mg（305mg钙）
胆钙化醇（日常办公）0.005（200IU）
碳酸镁（日本药典）59.2mg（15毫克如镁）
商標名
DENOTAS CHEWABLE COMBINATION TABLETS
1.沉淀碳酸钙
一般名
沈降炭酸カルシウム（Precipitated Calcium Carbonate）
分子式
CaCO3
分子量
100.09
性状
白色细结晶性粉末，无臭，味。和几乎不溶于水，但以增加二氧化碳的溶解度存在。乙醇（95）或它不是在乙醚几乎不溶。融化在鼓泡到稀醋酸，稀盐酸或稀硝酸。
2.胆钙化醇
一般名
コレカルシフェロール（Cholecalciferol）
化学名
（3S, 5Z, 7E）-9, 10-Secocholesta-5, 7, 10（19）-trien-3-ol
分子式
C27H44O
分子量
384.64
構造式

性状
白色晶体，无异味。乙醇（95），氯仿，溶于二乙醚或异辛烷，和几乎不溶于水。它通过改变空气或在光照。
融点
84～88℃
3.碳酸镁
一般名
炭酸マグネシウム（Magnesium Carbonate）
分子式
MgCO3
分子量
84.31
性状
在白，脆质或粉末，无臭味。水，乙醇（95），和在1-丙醇或乙醚几乎不溶。熔体发泡稀盐酸。饱和水溶液呈碱性。
操作注意事项
由于质量下降已观察到，由于吸湿性和光，你不要单独封装。
药效药理
血钙神经传递，肌肉收缩，是参与，如血液凝固。
天然维生素D（维生素D2和D3），以作为在肝脏25（OH）D的代谢，在肾脏更活性的维生素D（1,25（OH）2D）旁边它促进钙的吸收在小肠，肾脏和在并通过促进再吸收钙的肾小管，从而增加血钙。
镁参与钙的代谢。
适应症
RANKL抑制剂（狄诺塞麦（基因重组）等）的治疗和预防低钙血症与管理相关。
用法用量
正常情况下，两片，每天一次口服给药。该剂量可以适当地根据患者的状态或临床实验值进行调整
包装规格
咀嚼组合片剂
（塑料瓶）56片100片 （SP）60片

生产厂商
日东制药工业有限公司[联盟]第一三共有限公司

DENOTAS CHEWABLE CONBINATION TABLETS（デノタスチュアブル配合錠 Precipitated Calcium Carbonate/Cholecalciferol/Magnesium Carbonate）
Brand name : DENOTAS CHEWABLE CONBINATION TABLETS
　Active ingredient: Precipitated calcium carbonate
 Cholecalciferol
 Magnesium carbonate
　Dosage form: Almost white to pale yellow tablet, diameter: 14.1 mm, thickness: 6.4 mm
　Print on wrapping: デノタスチュアブル配合錠, (plastic bottle) 56錠 or 100錠, (SP) DENOTAS 
Effects of this medicine
This medicine contains calcium, natural vitamin D3 (cholecalciferol) and magnesium carbonate. Blood calcium is engaged in actions such as neurotransmission, muscle contraction and blood coagulation. Natural Vitamin D (Vitamin D2 and D3) is metabolized in the liver to 25(OH) D and then turns into activated vitamin D [1, 25(OH)2D] in the kidney. It increases the blood calcium by promoting calcium absorption in the small intestine and enhancing calcium reabsorption in the renal tubular. Magnesium is involved in calcium metabolism.
It is usually used to treat or prevent hypocalcemia associated with the use of RANKL inhibitors (denosumab [recombinant], etc.).
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have hypercalcemia or renal disorder.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
In general, for adults, take 2 tablets at a time, once daily. However, the dosage should be adjusted based on age and symptoms of the patient. Strictly follow the instructions.
This medicine is chewable. Chew or dissolve the tablet in your mouth.
If you miss a dose, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one dose. Never double the prescribed dose at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
Blood calcium may have to be measured while medication. Please follow your doctor's instructions and take a test on your designated date and time.
Be aware that disorders such as hypercalcemia may occur when you drink a large amount of milk during medication.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include rash, erythema, itch, constipation and diarrhea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep out the reach of children. Store away from light, heat and moisture.
In case of plastic bottle, screw the cap tightly after use.
Do not replace the contents to a different container.
NITTO PHARMACEUTICAL INDUSTRIES,LTD. Internal
Revised: 4/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://www.info.pmda.go.jp/go/pack/3219100F1020_1_03/3219100F1020_1_03?view=body#14