英文药名：EXFORGE Combination OD Tablets （Valsartan/Amlodipine Besilate）

中文药名：缬沙坦/氨氯地平配合口腔崩解片

生产厂家：诺华制药（Novartis）
治疗类别名称
选择性AT1受体阻滞剂/持续性钙拮抗剂组合

構造式
一般名
バルサルタン（Valsartan）
化学名
（2S）-3-Methyl-2-（N-｛［2'-（1H-tetrazol-5-yl）biphenyl-4-yl］methyl｝pentanamido）butanoic acid
分子式
C24H29N5O3
分子量
435.52
性状
它是一种白色粉末。甲醇，这是非常易溶于乙醇（99.5），并且几乎不溶于水

構造式
一般名
アムロジピンベシル酸塩（Amlodipine Besilate）
化学名
3-Ethyl 5-methyl（4RS）-2-［（2-aminoethoxy）methyl］-4-（2-chlorophenyl）-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate monobenzenesulfonate
分子式
C20H25ClN2O5・C6H6O3S
分子量
567.05
性状
它是白色结晶粉末微黄的颜色。它是易溶于甲醇，稍少溶于乙醇（99.5），它是微溶于水。甲醇溶液（1→100）示出了没有旋光性。
操作注意事项
由于这种药物具有吸湿性，保存遗体PTP板材
药效药理
缬沙坦和氨氯地平的组合药物。缬沙坦结合AT1的血管紧张素II受体受体亚型，通过拮抗抗血管紧张素II，其充当升压系统发挥降压作用。氨氯地平结合电压依赖性钙通道，通过抑制钙流入细胞，并使其松弛的末梢血管的平滑肌表现出降压作用。即交感神经系统是由氨氯地平的降压作用激活，依赖于肾素 - 血管紧张素系统在血压调节上增加，增强缬沙坦的降压作用。
当施用缬沙坦和氨氯地平在超过各化合物的单次施用的自发性高血压大鼠，降压效果的组合已经显示。
适应症
高血圧症
用法用量
成人一天（5毫克如80毫克和氨氯地平作为缬沙坦）一种片剂一旦被口服给药。
包装规格
80毫克/5毫克
エックスフォージ配合OD錠　140錠（PTP）　500錠（PTP）　700錠（PTP）

生产商
日本诺华制药
EXFORGE Combination OD Tablets（エックスフォージ配合OD錠）
Brand name : EXFORGE Combination OD Tablets
　Active ingredient: Valsartan
 Amlodipine besilate
　Dosage form: white tablet, diameter: 10.0 mm, thickness: 5.5 mm
　Print on wrapping: エックスフォージ配合OD錠, EXFORGE, NV145
Effects of this medicine
This medicine blocks the vasoconstrictive effects of angiotensin II produced in the body, and dilates peripheral blood vessel to lower blood pressure in patients with hypertension.
It is usually used to treat hypertension.
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have: diabetes mellitus, renal disorder, hepatic disorder, hyperkalemia or schedule of surgery.
If you are on dialysis or a regimen of low-salt diet.
If you are pregnant, possibly pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
In general, for adults, take 1 tablet at a time, once a day. Strictly follow the instructions.
You can take the medicine without water. Soak the tablet with saliva on your tongue and crush it lightly with your tongue, then swallow it with saliva. You can also take it with water or warm water as you do an ordinary tablet. However, you should never take the tablet without water when you are in a lying position.
Tablets may be broken or chipped. However, the quality of the tablet is unaffected. Take the entire prescribed amount of the medicine including the fragments.
If you miss a dose, take a dose as soon as possible. However, if it is 8 hours or less before the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
The medicine may cause dizziness or light-headedness since the blood pressure is decreased. Pay attention when you work at heights, drive a car or operate dangerous machinery.
Avoid taking the medicine with grapefruit juice, as it may intensify the effect of the medicine.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include dizziness and rash. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
swelling in face/throat/tongue, breathlessness [angioedema]
loss of appetite, general malaise, yellowness in skin or conjunctiva [hepatitis, hepatic dysfunction, jaundice]
decrease of urine output, edema, loss of appetite [renal failure]
loss of consciousness, vomiting, cold feeling [shock, faint, loss of consciousness]
numbness of lips or limbs, muscle weakness, paralysis in limbs [hyperkalemia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep out the reach of children. Store away from direct sunlight, heat and moisture. Keep in press-through package (PTP) sheet just before taking.
Discard the remainder. Do not store them. Ask the pharmacy or medical institution how to discard.
Novartis Pharma K.K. Internal
Revised: 7/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.