英文药名：BEC Capsules/Granules 2%(Aranidipine)

中文药名：阿雷地平胶囊/细粒 2%

生产厂家：Nichi-IKO药业

ベックカプセル5mg／ベックカプセル10mg／ベック顆粒2％

治疗类别名称
持续钙拮抗剂
欧文商標名
BEC
一般名：
アラニジピン（Aranidipine：JAN）
化学名：
(±)-Methyl 2-oxopropyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate

分子式：
C19H20N2O7
分子量：
388.37
性状：
在黄色的晶体或结晶粉末，没有异味。
丙酮，易溶于二氯甲烷或1,4-二恶烷，难溶在甲醇中，在乙醇（99.5）微溶，极微溶于乙醚，和几乎不溶于水。
它是由光的影响。
此产物1,4-二恶烷溶液（1→50）的显示没有旋光性。
熔点：
148〜151℃
分配系数：
3×102（1-辛醇/水体系的溶剂，pH2的〜9）
操作注意事项
冲剂，但一直包衣颗粒的活性成分是不稳定的光，告诫不要轻信尽可能多的光，如果你想分配。
药效药理
1. 降圧作用
(1) 每日施用一次至高血压患者中，在不影响血压天变型中，观察到稳定的降压作用，直到第二天。
(2) 自发性高血压大鼠，大鼠肾性高血压，单次口服给药使用醋酸去氧皮质酮 - 盐加载高血压大鼠和肾性高血压的狗，降压剂量依赖性的效果进行了观察。
此外，在22周的饮食管理，我们使用的是中风多发的自发性高血压大鼠，抑制血压上升，进一步高血压器官损伤（脑中风，心肌纤维化，增生性坏死性小动脉炎，恶性肾硬化等。发病）压制，观察延长生命的效果。
2. 对血流动力学的影响
(1) 血液动力学靶向高血压光适中，降压作用的调查结果，发现主要是由于在总外周阻力（11至16％）的降低。
(2) 在口服给药使用自发性高血压大鼠，肾血流量，尿量，观察到的增加尿Na +和K+排泄。
3. 降圧作用机序
(1) 在主动脉标本豚鼠，以抑制流入的钙离子的小区，在猪主动脉标本，抑制依赖于浓度的方式结合于尼群地平的受体。另外，在豚鼠分离的心室肌细胞，并且以依赖于浓度的方式向内钙离子电流。
(2) 这种药物的作用的主要机制作用于血管平滑肌细胞钙通道，通过抑制钙离子的流入外比细胞内放松血管平滑肌，该延长血管它被认为是发挥降血压作用。
适应病症
高血圧症
用法用量
初始剂量5毫克，通常给药为5-10毫克口服，每天一次在成人。
此外，年龄，但可以根据症状增加或减少适当的，如果该效果不充分，可提高到20毫克，每天1次。
包装规格
胶囊：
5毫克
100胶囊（10粒×10; PTP）
10毫克

100胶囊（10粒×10; PTP）

颗粒2％
0.25克×105包
0.25克×525包
0.5克×105包
0.5克×525包
100克（瓶）

制造厂商
Nichi-IKO公司
BEC Capsules（Aranidipine）Granules 2%
BEC Capsules 5mg（ベックカプセル5mg）
Brand name : BEC Capsules 5mg
　Active ingredient: Aranidipine
　Dosage form: orange capsule, major axis 14.5 mm, minor axis 5.3 mm
　Print on wrapping: BEC 5,社マーク＋2NE,ベック5,ベック5mg
BEC Capsules 10mg（ベックカプセル10mg）
Brand name : BEC Capsules 10mg
　Active ingredient: Aranidipine
　Dosage form: orange capsule, major axis 15.8 mm, minor axis 5.8 mm
　Print on wrapping: BEC 10,社マーク＋2NH,ベック10,ベック10mg
BEC Granules 2%（ベック顆粒2%）
Brand name : BEC Granules 2%
　Active ingredient: Aranidipine
　Dosage form: yellowish white to brownish yellow-white granule
　Print on wrapping: ＜0.25g packet＞ベック,5mg,0.25g,BEC,社マ−ク＋2CL
＜0.5g packet＞ベック,10mg,0.5g,BEC,社マ−ク＋2CM
Effects of this medicine
This medicine blocks calcium inflow into cells and consequently dilates constricted vessels to decrease blood pressure.
It is usually used to treat hypertension.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
•If you are pregnant, possibly pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adults, initially take 5 mg of the active ingredient at a time and take 5 to 10 mg at a time, once a day. The dosage may be adjusted according to age and symptoms of the patient. The dosage may be increased up to 2 capsules (20 mg) at a time, once a day, if the effect is insufficient. This preparation contains 10mg of the active ingredient in a capsule. Strictly follow the instructions.
•If you miss a dose, take a dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•This medicine may cause dizziness, etc. due to decreased blood pressure. Be aware of operating in potentially hazardous activities such as driving a car and working at heights.
•Do not take grapefruit juice and the medicine together as the components of it may intensify the effect of this medicine.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include headache, flushing, hot flash, palpitation, anemia, dizziness and rash. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them. Ask the pharmacist or medical facility how to discard unneeded medicine.
Nichi-iko Pharmaceutical Co.,LtdInternal
Revised: 2/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://www.info.pmda.go.jp/go/pack/2149038D1052_2_01/