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药品名称
通用名称：醋酸甲地孕酮片
英文名称：Megestrol Acetate Tablets
规 格
160mg/20mg/40mg
药理毒理
本品为孕激素对垂体促性腺激素的释放有一定的抑制作用，但比左炔诺孕酮和炔诺酮为弱。不具有雌激素和雄激素样活性，但有明显抗雌激素作用。与雌激素合用，抑制排卵。动物致畸试验表明对家兔具有死胎率增加和致畸作用。
药代动力学
口服后生物半衰期明显比左炔诺孕酮为短，大部分代谢产物以葡萄糖醛酸酯形式排出.
适应症
治疗月经不调、功能性子宫出血、子宫内膜异位症；晚期乳腺癌和子宫内膜腺癌；亦可用于短效复方口服避孕片的孕激素成分.
用法用量
口服：
1）治疗闭经（雌激素水平足够时），一次4mg，一日2-3次，连服2-3日，停药2周内即有撤退性出血；
2）治疗功能性子宫出血，一日4mg-8mg，共20天，开始自月经第5天服或同于1）；
3）治疗子宫内膜异位症，一次4mg-8mg，一日1-2次，自月经第5天服，连服3-6个月；
4）乳腺癌，一次40mg，一日4次，一日量160mg，连续2个月；
5）子宫内膜癌，一次10-80mg，一日4次，一日量40-320mg,或一次160mg，每日一次.
任何疑问，请遵医嘱！
不良反应
①主要为恶心，头晕，倦怠；
②突破性出血；
③孕期服用有比较明确的增加女性后代男性化的作用.
禁 忌
严重肝，肾功能不全者，乳房肿块者，孕妇禁用.
注意事项
1）有子宫肌瘤，血栓病史及高血压、糖尿病、哮喘病、癫痫、偏头痛、精神抑郁患者慎用。
2）长期用药注意检查肝功能、乳房检查.
孕妇及哺乳期妇女用药
孕妇及哺乳期妇女用药禁用.
贮 藏
遮光，密封保存
英文药名: Megace (Megesterol Acetate Tablets)
中文药名: 醋酸甲地孕酮片
生产厂家: Bristol Meyers Squibb
【原产地英文商品名】MEGACE TABLET 160mg/tab 30tabs/box
【原产地英文药品名】MEGESTROL ACETATE
【中文参考商品译名】
注：以下产品不同的规格和不同的价格，购买时请以电话咨询为准！
·梅格施片剂 160毫克/片 30片/盒
·甲地孕酮片剂(梅格施仿制药) 20毫克/片 100片/盒
·甲地孕酮片剂(梅格施仿制药) 40毫克/片 100片/盒
【中文参考药品译名】醋酸甲地孕酮
【生产厂家中文参考译名】百时美施贵宝
【生产厂家英文名】BRISTOL MYERS SQUIBB
Megace (megestrol acetate)
How does it work?
Megace tablets contain the active ingredient megestrol acetate, which is a synthetic form of the naturally occurring female sex hormone, progesterone. It is used to treat women with certain hormone-dependant cancers.
Most breast cancers and cancers affecting the womb (endometrial cancers) are sensitive to the female sex hormone oestrogen, and their growth is increased in the presence of this hormone. Oestrogen binds to oestrogen receptors on the cancer cells and causes changes within the cells that result in faster growth of the cancer.
Megestrol opposes the action of oestrogen, which means that the growth and replication of cancer cells is disrupted.
Megace tablets must usually be taken for at least two months to see if they are being effective.
What is it used for?
Breast cancer.
Endometrial cancer.
Warning!
This medicine can cause abnormal blood clots in the blood vessels (for example deep vein thrombosis or pulmonary embolism), particularly during periods of immobilisation and following surgery. For this reason you should consult your doctor immediately if you experience any of the following symptoms during treatment: stabbing pains and/or unusual swelling in one leg, pain on breathing or coughing, coughing up blood, sudden breathlessness, sudden numbness affecting one side or part of the body, sudden or severe headache, fainting or sudden severe chest pain.
Women who could get pregnant should use an effective method of contraception to avoid pregnancy while taking this medicine, as it could be harmful to a developing baby.
Use with caution in
People with a history of inflammation of the veins associated with blood clots (thrombophlebitis).
Severely decreased liver function.
Hereditary blood disorders called porphyrias.
Not to be used in
Pregnancy.
Breastfeeding.
People with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption. (Megace tablets contain lactose)
This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
This medicine should not be used during pregnancy as it may be harmful to the unborn baby. Seek medical advice from your doctor.
Women who could get pregnant should use an effective method of contraception to avoid pregnancy while taking this medicine, as it could be harmful to a developing baby.
This medicine may pass into breast milk. Mothers who need treatment with this medicine should not breastfeed. Seek medical advice from your doctor.
Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Increased appetite and weight gain.
Nausea and vomiting.
Swelling due to fluid retention.
Vaginal bleeding (breakthrough bleeding or spotting).
Difficulty breathing or shortness of breath (dyspnoea).
Heart failure.
High blood pressure.
Hot flushes.
Changes in mood.
High blood glucose level (hyperglycaemia).
Temporary stimulation of tumour growth (tumour flare).
Hair loss (alopecia).
Carpel tunnel syndrome.
Abnormal blood clots in the veins (thromboembolism – see warning section above).
Itchy rash (urticaria).
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
There are no significant interactions reported with this medicine.
However, it is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to make sure that the combination is safe.
Other medicines containing the same active ingredient
There are currently no other medicines available in the UK that contain megestrol acetate as the active ingredient. | 
