英文药名: Tobradex (Dexamethasone/tobramycin)

中文药名: 典必殊（地塞米松妥布霉素）

药品名称
【别名】妥布霉素-地塞米松滴眼剂,点必舒,典必殊

生产厂家
Alcon Labratories Inc. 爱尔康

规格
滴眼剂:0.3%妥布霉素 0.1%地塞米松;
眼膏剂:每克含妥布霉素3.0mg 地塞米松1.0mg.

药理作用
妥布霉素具有广谱抗菌作用，能够有效地杀灭细菌、控制感染，并具有极佳的角膜安全性和更为持久的PAE（抗菌素后续作用时间）；地塞米松具有抗炎效果显著、角膜穿透力好等优点。妥布霉素和地塞米松的结合充分发挥了各自的优点，能够非常安全有效地控制眼部感染及炎症。

适应症
*术前、术后预防、治疗感染与炎症反应
*结膜炎、外周角膜炎、泪囊炎与化学灼伤
*RK、PRK术前、术后

用法用量
*混悬液：1-2滴/4-6小时，最初1-2天可增至2小时一次
*眼药膏：取1-1.5cm长的药膏点入结膜囊中，3-4次/日，或仅睡前用
*术后用药方法：　　
术后第1、2天，每两小时一次，每次2滴；第3-14天，每日四次，每次1滴；以后逐减（注：注意监测眼压）。
任何疑问，请遵医嘱！

不良反应
有过敏反应,如眼睑发痒与红肿,结膜红斑.

禁忌症　　
树枝状角膜炎。牛痘、水痘及其它因滤过性病毒引起的角膜炎、结膜炎。眼睛分枝杆菌感染。眼结构的真菌感染；对本品任何成份过敏者及角膜上异物未完全去除者。

Tobradex
Generic Name: tobramycin and dexamethasone ophthalmic (TOE bra MYE sin and DEX a METH a sone off THAL mik)
Brand Names: Tobradex

What is Tobradex?
Tobradex contains a combination of tobramycin and dexamethasone. Tobramycin is an antibiotic. It is used to treat bacterial infections.

Dexamethasone is a steroid. Dexamethasone ophthalmic is used to treat the swelling associated with bacterial infections of the eye.

Tobradex is used to treat bacterial infections of the eyes.

Tobradex may also be used for purposes other than those listed in this medication guide.

Important information aboutTobradex
Contact your doctor if the symptoms begin to get worse or if you do not see any improvement in the condition after a few days.

Do not touch the dropper or tube opening to any surface, including your eyes or hands. The dropper or tube opening is sterile. If it becomes contaminated, it could cause an infection in the eye.

Apply light pressure to the inside corner of your eye (near your nose) after each drop to prevent the fluid from draining down your tear duct.

What should I discuss with my doctor before using ?
Do not use Tobradex if you have a viral or fungal infection in the eye. It is used to treat infections caused by bacteria only. It is not known whether Tobradex will be harmful to an unborn baby. Do not use Tobradex without first talking to your doctor if you are pregnant. It is not known whether tobramycin or dexamethasone passes into breast milk. Do not use this medication without first talking to your doctor if you are breast-feeding a baby.

How should I use Tobradex?
Use Tobradex eye drops or ointment exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after using the eye drops or ointment.

To apply the eye drops:
Shake the drops gently to be sure the medicine is well mixed. Tilt your head back slightly and pull down on your lower eyelid. Position the dropper above your eye. Look up and away from the dropper. Squeeze out a drop and close your eye. Apply gentle pressure to the inside corner of your eye (near your nose) for about 1 minute to prevent the liquid from draining down your tear duct. If you are using more than one drop in the same eye, repeat the process with about 5 minutes between drops. If you are using drops in both eyes, repeat the process in the other eye.

To apply the ointment:
Hold the tube in your hand for a few minutes to warm it up so that the ointment comes out easily. Tilt your head back slightly and pull down gently on your lower eyelid. Apply a thin film of the ointment into your lower eyelid. Close your eye and roll your eyeball around in all directions for 1 to 2 minutes. If you are applying another eye medication, allow at least 10 minutes before application of the other medication.

Do not touch the dropper or tube opening to any surface, including your eyes or hands. The dropper or tube opening is sterile. If it becomes contaminated, it could cause an infection in the eye. Do not use any eyedrop that is discolored or has particles in it. Store Tobradex at room temperature away from moisture and heat. Keep the bottle or tube properly capped.

What happens if I miss a dose?
Apply the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and apply the next one as directed. Do not use a double dose of this medication.

What happens if I overdose?
An overdose of Tobradex is unlikely to occur. If you do suspect an overdose or if the medication has been ingested, contact an emergency room or poison control center for advice.

What should I avoid while using Tobradex?
Do not touch the dropper or tube opening to any surface, including your eyes or hands. The dropper or tube opening is sterile. If it becomes contaminated, it could cause an infection in the eye. Use caution when driving, operating machinery, or performing other hazardous activities. Tobradex may cause blurred vision. If you experience blurred vision, avoid these activities.

If you wear contact lenses, ask your doctor if you should wear them during treatment with Tobradex. After applying the medication, wait at least 15 minutes before inserting contact lenses, unless otherwise directed by your doctor.

Do not use other eye drops or medications during treatment with Tobradex unless otherwise directed by your doctor.

Tobradex side effects
Serious side effects are not expected to occur with the use of Tobradex.

Some burning, stinging, irritation, itching, redness, blurred vision, eyelid itching, eyelid swelling, or sensitivity to light may occur.

This is not a complete list of Tobradex side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Tobradex?
Do not use other eye drops or medications during treatment with Tobradex unless otherwise directed by your doctor.

Before using Tobradex, tell your doctor if you are taking an oral steroid medication such as prednisone (Deltasone, Orasone, others).

Drugs other than those listed here may also interact with Tobradex. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Where can I get more information?
Your pharmacist has additional information about Tobradex written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist