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当前位置:药品说明书与价格首页 >> 抗肿瘤药 >> 药品目录 >> 激素类 >> 内分泌类 >> 缓退瘤片(氟他胺片)|Euflex (Flutamide Tablets)

缓退瘤片(氟他胺片)|Euflex (Flutamide Tablets)

2011-02-07 10:55:57  作者:新特药房  来源:中国新特药网天津分站  浏览次数:532  文字大小:【】【】【
简介: 英文药名: Euflex (Flutamide Tablets) 中文药名: 氟他胺片,氟硝胺,氟硝丁酰苯胺,福至尔,缓退瘤 药品名称 中文通用名称:氟他胺 英文通用名称:Flutamide 中文其它名称:缓退瘤, 氟他米特, ...

英文药名: Euflex (Flutamide Tablets)

中文药名: 氟他胺片,氟硝胺,氟硝丁酰苯胺,福至尔,缓退瘤

药品名称

中文通用名称:氟他胺
英文通用名称:Flutamide
中文其它名称:缓退瘤, 氟他米特, 福至尔, 氟利坦, 氟硝丁酰胺, 氟甲酰亚胺, 氟他胺片, 氟他胺胶囊
英文其它名称:Sebatrol, Fugerel, Flucinom, Flutan, Euflex, Eulexin, Cebratrol, Drogenil, Flutamid, Flutarmide, Elexin, Odyne, Prostogenat, Flutamide Capsules, Flutamide Tablets
产品所属分类:男性生殖系统用药\雄激素类及抗雄激素类药
适应症
1.与促黄体激素释放激素(LHRH)类似物联合使用,治疗前列腺癌。
2.本药的酒精凝胶(alcoholic gel)制剂可用于治疗痤疮。
用法用量
成人
*常规剂量
*口服给药: 一次250mg,一日3次。
[国外用法用量参考]
成人
*常规剂量
*口服给药
1.治疗B★2★-C期前列腺癌:于放射治疗前8周开始,一次250mg,一日3次,每次间隔8小时,并与LHRH激动剂合用。在放疗期间也应持续用药。
2.治疗D★2★期前列腺癌:一次250mg,一日3次,每次间隔8小时,与LHRH激动剂合用至病情有所改善。
*外用
治疗痤疮:2%的酒精凝胶一日2次,维持4-6周。
任何疑问,请遵医嘱!
给药说明

1.本药宜于饭后服用。
2.用药期间发现肝功能异常时应及时停药。
3.治疗期间应避孕。
4.据国外资料报道,每8小时口服250mg本药,能有效消除继发于LHRH激动剂治疗D★2★期前列腺癌的疾病爆发的危险性;合用本药和LHRH乙酰胺[D-Trp(6)]可迅速改善病情。
不良反应
1.心血管系统
本药对心血管系统影响较已烯雌酚有较大减少。可引起体液潴留,少数患者有心悸,很少出现血栓形成和肺栓塞。
2.中枢神经系统
本药单用时,少见失眠、疲倦。
3.泌尿生殖系统
本药单用时,偶见性欲减退;与LHRH类似物联合使用时,常见性欲下降、阳萎,长期用药精子计数减少。
4.肝脏
本药单用时,少见丙氨酸氨基转移酶升高等一过性肝功能异常和肝炎,但曾有因严重肝脏损害引起死亡的报道。
5.胃肠道
本药单用时,少见恶心、呕吐、腹泻;与LHRH类似物联合使用时,常见上述胃肠道反应。
6.其它
本药单用时,常见男性乳房女性化和(或)乳房触痛,有时伴溢乳,偶见乳腺体发生小结节改变,以上反应可在停药或减量后消失;少数患者有乳头痛、血清睾丸酮反馈性升高。与LHRH类似物联合使用时,常见潮热。
注意事项

1.禁忌症
(1)对本药过敏者。
(2)严重肝脏损害者(国外资料)。
2.慎用
(1)肝功能不全者。
(2)心血管病患者(本药可使血清睾酮和雄激素水平上升,可引起体液潴留)。
3.药物对妊娠的影响 美国药品和食品管理局(FDA)对本药的妊娠安全性分级为D级。
4.药物对哺乳的影响 尚不明确。
5.用药前后及用药时应当检查或监测 用药期间应定期检查肝功能(至少每月1次)、精子计数(未接受药物或手术去势的患者)、血压以及血清前列腺特异抗原。
规格
氟他胺片 250mg。

Eulexin, flutamide

Chemical Name
Flutamide

Ingredients
Active Ingredients: Flutamide
Non-Active Ingredients: Corn starch, lactose, magnesium stearate, povidone, and sodium lauryl sulfate. Gelatin capsule shells may contain methylparaben, propylparaben, butylparaben, and the following dye systems: FD&C Blue 1, FD&C Yellow 6, and either FD&C Red 3 or FD&C Red 40 plus D&C Yellow 10, with titanium dioxide and other inactive ingredients.

Indications
Eulexin is used during prostate cancer treatment. It discourages the growth and spread of cancer.

How It Works
It competes with testosterone and its powerful metabolite, dihydrotestosterone (DHT) for binding to androgen receptors in the prostate gland. By doing so, it prevents them from stimulating the prostate cancer cells to grow. Flutamide belongs to a class of drugs known as anti-androgens (anti-testosterone). Testosterone, a natural hormone, helps prostate cancer to grow and spread.

Dosage
Tablets (250 mg)

The recommended dosage is 2 capsules 3 times a day at 8-hour intervals for a total daily dose of 750 mg.

Precautions
Eulexin is contraindicated in people who have hypersensitivity to ingredients in Eulexin and with severe liver impairment. There has been reported male breast growth in males. Serious problems involving the heart have been noted while on this medication. Seriously cardiac lesions were reported in patients taking Eulexin. Malignant breast neoplasms have occurred in male patients being treated with Eulexin Capsules.

Taking this medication may result in serious liver damage including; brain damage as result of liver, dead liver tissue, yellowing of skin and eyes caused by liver damage, etc. There will be a need for the appropriate laboratory test to see the impact of the damage. Monitoring a patient?s serum Prostate Specific Antigen (PSA) might be necessary while on this medication to see how they respond. There is the possibility of reduced sperm count while on Eulexin.

This drug may rarely make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of this drug, especially drowsiness. Flutamide should not be used in women. Women who are pregnant should avoid touching or accidentally taking this medication. It may harm an unborn baby. Consult your doctor for more information. It is not known whether this drug passes into breast milk. Women who are breastfeeding should avoid touching or accidentally taking this medication. Consult your doctor for more information.

This medicine may cause harm to an unborn baby. Before taking Eulexin, tell your doctor if you are pregnant or plan to become pregnant during treatment. Eulexin passes into breast milk and may causes harm to a nursing baby. Consult your doctor before using this medication if you are pregnant or breast-feeding a baby.

Drink plenty of fluids as directed by your doctor to reduce your risk of losing too much body water.

You should consult a doctor before using this medication if you are allergic to Flutamide or similar medicines, or any of the other ingredients of Eulexin.

BUY EULEXIN ONLINE

Drug Interactions
Consult a doctor before taking Eulexin, if you are taking: testosterone, anabolic steroids, DHEA, Warfarin. Flutamide is usually used with other medications, the side effects may be caused by the other medications or their combination. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.
 
Before using this Eulexin, tell your doctor or pharmacist about all prescription and nonprescription medications, including herbal products, minerals and vitamins you may be taking. Other medications may affect how Eulexin works or may cause other unforeseen complications.

Adverse/Side Effects
It is common that Eulexin causes the following minor side effects: Hot flashes, loss of sexual interest/ability, diarrhea, nausea, vomiting, and enlargement of male breasts may occur. If these side effects persist or become overly bothersome contact your doctor or health-care professional.

Infrequent side effects: decreased amount of urine, dizziness, anemia, swelling of soft tissues as a result of excess water, dead skin, red blood cell depletion and anemia.

Rare side effects: hepatitis and jaundice, hypertension, CNS (drowsiness /confusion /depression /anxiety /nervousness) pulmonary symptoms, genital and neuromuscular symptoms, the presence in the blood of methemoglobin, mental/mood changes (such as depression, anxiety, nervousness), a breast lump, confusion, sudden severe tiredness, weakness, pale skin, bluish fingernails/lips/skin, fast heartbeat at rest, feeling short of breath at rest, pulmonary symptoms, presence of relatively few platelets in blood.

If any of these side effects become bothersome seek medical attention immediately.

A very serious allergic reaction to this drug is rare. Get emergency medical help if you have any of these signs of an allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing. This may not be a complete list of side effects and may be subject to change, consult with your doctor or pharmacist if you are experiencing any worrisome side effects.

Overdose
If you suspect overdose, contact your local poison control center or emergency room immediately.

Storage Instructions
Store between 2o and 30o C (36o and 86o F), away from moisture and light, and out of reach of children and pets.

责任编辑:admin


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