制造商：
Salix制药公司

药理分类：
促动力/ antidopaminergic

活性成分（补）：
胃复安（如盐酸）5毫克，10毫克，口服崩解片，薄荷味。
指示（补）：
短期（4-12周）治疗难治性胃食管反流病症状。为了减轻急性和复发性糖尿病胃轻瘫症状。

药理作用：
胃复安是一种有效的多巴胺受体拮抗剂作为止吐，促进胃排空和功能。胃排空障碍发生时，迷走神经受损，受损乙酰胆碱分泌及胃和肠道的肌肉正常收缩后的损失。胃复安对乙酰胆碱敏感组织无刺激，刺激胃，胆管，胰腺分泌物或上消化道蠕动。它增加的语调和胃收缩幅度，放松幽门括约肌和十二指肠球部和十二指肠和空肠增加肠蠕动，加速胃排空和肠道过境。胃复安也增加了较低的GERD的食管括约肌静息管理的基调。

胃复安施加通过拮抗中枢和外周多巴胺受体的止吐效果。多巴胺产生刺激延髓化学感受器触发区（CTZ），恶心和呕吐。胃复安块的CTZ由像左旋多巴制剂或吗啡，这是众所周知的增加多巴胺的多巴胺水平或具有类似效果的刺激。

Metozolv的ODT是一种口服崩解片剂盐酸胃复安。它必须在空腹至少30分钟前，因为吃的食物可降低该药物的峰浓度和/或花费的时间，在血液中达到最高药物浓度。若不慎与食品偶尔采取了一个四道 - 至12周的方案，这种减少是无临床意义。
法律分类：
接收

成人：
允许片剂解散的舌头。胃食管反流：10 - 15mg的每天4次，饭前30分钟及睡前。间歇性的症状：高达20毫克之前挑衅的情况，最大每疗程12周。糖尿病胃轻瘫：10毫克每日4次，饭前30 2-8周，在睡前分钟。肾功能损害：减少剂量。

儿童：
不推荐。

禁忌（补）：
当刺激胃肠运动可能是危险的（例如，梗阻，穿孔或出血）。嗜铬细胞瘤。癫痫。伴随药物可能导致锥体外系反应（如抗抑郁药，抗精神病药物，抗精神病药）。

警告/注意事项：
如果停止的迹象/迟发性运动障碍症状的发展;与治疗的累积剂量和总工期风险增加。帕金森氏症。历史的抑郁症。高血压。瑞士法郎。心律失常。老人。妊娠（Cat.B）。哺乳的母亲。

互动（补）：
高血压危象与单胺氧化抑制剂。添加剂镇静与酒精，镇静剂等中枢神经系统。拮抗抗胆碱能药物和毒品。监视器使用胰岛素;可减少胃癌和加快药物或食物肠道的吸收。

不良反应（补）：
头痛，恶心，呕吐，乏力，嗜睡，头晕，锥体外系反应，帕金森病，迟发性运动障碍，抗精神病药物恶性症候群，高血压。

如何提供：
制表- 10 × 10（吸塑包装）

最后更新：
2010/2/2

Indication(s):

Short-term (4–12 weeks) therapy for symptomatic refractory GERD. To relieve symptoms associated with acute and recurrent diabetic gastroparesis.

Pharmacology:

Metoclopramide is a potent dopamine receptor antagonist that promotes gastric emptying and functions as an antiemetic. Delayed gastric emptying occurs when the vagus nerve is damaged, resulting in impaired acetylcholine secretion and subsequent loss of normal contractility of the muscles of the stomach and intestines. Metoclopramide sensitizes tissues to acetylcholine to stimulate upper GI tract motility without stimulating gastric, biliary, or pancreatic secretions. It increases the tone and amplitude of gastric contraction, relaxes the pyloric sphincter and duodenal bulb, and increases peristalsis of the duodenum and jejunum to accelerate gastric emptying and intestinal transit. Metoclopramide also increases the resting tone of the lower esophageal sphincter for the management of GERD.

Metoclopramide exerts its antiemetic effects by antagonizing central and peripheral dopamine receptors. Dopamine produces nausea and vomiting by stimulating the medullary chemoreceptor trigger zone (CTZ). Metoclopramide blocks the stimulation of the CTZ by agents like l-dopa or apomorphine, which are known to increase dopamine levels or possess dopamine-like effects.

Metozolv ODT is an orally disintegrating tablet formulation of metoclopramide hydrochloride. It should be taken on an empty stomach at least 30 minutes before eating since food can decrease the peak concentration of the drug and/or time it takes to achieve the maximum drug level in the bloodstream. If inadvertently taken with food occasionally over the course of a 4- to12-week regimen, this decrease is not clinically significant.

Legal Classification:

Rx

Adults:

Allow tablet to dissolve on tongue. GERD: 10–15mg 4 times daily 30 minutes before meals and at bedtime. Intermittent symptoms: up to 20mg prior to provoking situation; max 12 weeks per therapeutic course. Diabetic gastroparesis: 10mg 4 times daily 30 minutes before meals and at bedtime for 2–8 weeks. Renal impairment: reduce dose.

Children:

Not recommended.

Contraindication(s):

When stimulation of GI motility may be dangerous (eg, obstruction, perforation, or hemorrhage). Pheochromocytoma. Epilepsy. Concomitant drugs which may cause extrapyramidal reactions (eg, antidepressants, antipsychotics, neuroleptics).

Warnings/Precautions:

Discontinue if signs/symptoms of tardive dyskinesia develop; risk increases with duration of treatment and total cumulative dose. Parkinsonism. History of depression. Hypertension. CHF. Arrhythmia. Elderly. Pregnancy (Cat.B). Nursing mothers.

Interaction(s):

Hypertensive crisis with MAOIs. Additive sedation with alcohol, other CNS depressants. Antagonized by anticholinergics and narcotics. Monitor insulin use; may diminish gastric and accelerate intestinal absorption of drugs or food.

Adverse Reaction(s):

Headache, nausea, vomiting, fatigue, somnolence, dizziness, extrapyramidal effects, parkinsonism, tardive dyskinesia, neuroleptic malignant syndrome, hypertension.

How Supplied:

Tabs—10 x 10 (blister packs)