中文药名: 群多普利维拉帕米缓释片

品牌药生产厂家: Abbott

TARKA 2/180
Generic Name for TARKA 2/180
Trandolapril 2mg, verapamil HCl 180mg (ext-rel); tabs.

Legal Classification:
Rx

Pharmacological Class for TARKA 2/180
ACE inhibitor + calcium channel blocker (diphenylalkylamine).

Manufacturer of TARKA 2/180
Abbott Laboratories
 

Indications for TARKA 2/180
Hypertension.

Adult dose for TARKA 2/180
Not for initial therapy. Titrate individual components. Take with food. ≥18yrs: 1 tab daily.

Children's dosing for TARKA 2/180
<18yrs: not recommended.

Also:
TARKA 1/240
TARKA 2/240
TARKA 4/240

Contraindications for TARKA 2/180
History of ACEI-associated angioedema. Severe left ventricular (LV) dysfunction or LV dysfunction treated with β-blockers. Moderate to severe heart failure. Hypotension. Cardiogenic shock. Sick sinus syndrome, 2nd- or 3rd-degree AV block, unless paced. Atrial flutter or fibrillation and an accessory bypass tract. Pregnancy (Cat.D in 2nd and 3rd trimesters).

Warnings/Precautions for TARKA 2/180
Discontinue if laryngeal edema, angioedema, or jaundice occurs. Hepatic or renal dysfunction. Salt/volume depletion. CHF. Renal artery or aortic stenosis. Cerebrovascular or ischemic heart disease. Monitor liver function. Monitor for neutropenia in collagen vascular and/or renal disease and for hyperkalemia in diabetics. Dialysis (esp. high-flux membrane). Surgery. Black patients may have higher risk of angioedema than non-black patients. Control mild heart failure (eg, with digitalis, diuretics). AV conduction or neuromuscular transmission disorders. Hypertrophic cardiomyopathy. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended.

Interactions for TARKA 2/180
For trandolapril: Excessive hypotension with diuretics. Hyperkalemia with K+ supplements, K+-sparing diuretics, salt substitutes. May increase lithium levels. For verapamil: Potentiates alcohol, β-blockers, other antihypertensives, digitalis, theophylline, neuromuscular blockers, flecainide, carbamazepine, cyclosporine. Potentiated by grapefruit juice. Avoid disopyramide; quinidine in cardiomyopathy. Potentiated by CYP3A4 inhibitors (eg, erythromycin, ritonavir); antagonized by CYP3A4 inducers (eg, rifampin). Inhalation anesthetics may potentiate cardiac depression. May increase bleeding with aspirin. Monitor theophylline, lithium.

Adverse Reactions for TARKA 2/180
Cough, AV block, constipation, dizziness, elevated liver enzymes, fatigue, chest pain, bradycardia, joint pain, GI upset, bronchitis, dyspnea, pain in extremities, paralytic ileus.

How is TARKA 2/180 supplied?
Tabs—100

通用名称塔卡180分之2
群多普利2毫克，180毫克盐酸维拉帕米（内线- REL的）;标签。

法律分类：
接收

药理班塔卡2/180
ACE抑制剂+钙通道阻滞剂（diphenylalkylamine）。

制造商塔卡2/180
雅培公司 

适应症塔卡2/180
高血压。

成人剂量塔卡2/180
不适用于初步治疗。滴定单个组件。随身携带的食物。 ≥18yrs：1标签日报。

儿童剂量为塔卡2/180 

“18yrs：不推荐。

另外：
塔卡二百四分之一
塔卡二百四十〇分之二
塔卡二百四十○分之四

禁忌症为塔卡180分之2
血管紧张素转换酶抑制剂的历史相关的血管性水肿。严重左心室（LV）功能不全或左室功能障碍的β-受体阻滞剂治疗。中度至重度心力衰竭。低血压。心源性休克。病态窦房结综合征，第二或第三度房室传导阻滞，除非节奏。心房扑动或颤动和从犯旁路道。妊娠（Cat.D在第二和第三孕期）。

警告/注意事项塔卡2/180
如果停止喉头水肿，血管性水肿，或黄疸发生。肝，肾功能不全。盐/容量减少。瑞士法郎。肾动脉或主动脉瓣狭窄。脑血管或缺血性心脏病。监测肝功能。监控胶原血管和/或肾脏疾病在糖尿病患者中性粒细胞和高钾血症。透析（尤其是高通量膜）。手术。黑人患者可能有更高的比非黑人患者的血管性水肿的危险。控制轻度心力衰竭（如洋地黄，利尿剂）。房室传导或神经肌肉传递障碍。肥厚性心肌病。怀孕（在第一学期Cat.C）。哺乳母亲：不推荐。

互作塔卡180分之2
对于群多普利：过度使用利尿剂低血压。高钾血症与K +的补充，钾利尿剂，代盐。可能会增加锂的水平。对于维拉帕米：Potentiates醇，β-阻断剂，其他抗高血压药，洋地黄，茶碱，神经肌肉阻断剂，氟卡尼，卡马西平，环孢素。 Potentiated的葡萄柚汁。避免丙吡胺，奎尼丁在心肌病。 Potentiated被CYP3A4抑制剂（如红霉素，利托那韦），由CYP3A4的诱导剂（如利福平）拮抗。吸入麻醉剂，会增强心脏抑郁症。阿司匹林可能会增加出血。监测茶碱，锂。

为塔卡一百八十○分之二不良反应
咳嗽，房室传导阻滞，便秘，头晕，肝酶升高，疲劳，胸痛，心动过缓，关节疼痛，胃肠不适，支气管炎，呼吸困难，四肢疼痛，麻痹性肠梗阻。

如何塔卡2/180提供？
制表- 100