中文药名: 丙嗪胶囊,奥沙普秦,苯恶丙酸

生产厂家: Pfizer

药品名称

通用名称：奥沙普秦
英文名：Oxaprozin
其它中文名：苯恶丙酸、苯恶丙嗪、恶丙嗪、二苯恶唑丙酸
其它英文名：Actirin、Daypro、Durapro、Duraprox、Dxaprozin、Oxapro、Oxaprozine
药理作用　　

本品的消炎、镇痛、解热作用主要由于抑制前列腺素的合成作用。其对消化道损害极弱，而疗效持久。健康成人一次口服本品400mg时，血中浓度约2～4小时后达最高，半衰期为50小时，连续给药，无论其给药方法如何，3～5日内血中浓度达定值(约100μg/ml)，且饭前饭后服药对体内动态没有影响，健康成人，一次口服本品400mg时，约60％在尿中得到回收，本品的主要代谢物是酯型葡萄糖醛酸物，此外是苯基的羟基物及其它的葡萄糖醛酸物。
适应症　　

本品用于慢性风湿性关节炎、变形性关节炎、腰痛症，变形性脊椎炎，颈肩腕综合征，肩关节周围炎，痛风发作，外伤后及手术后的消炎镇痛。
用法用量　　

每日剂量400mg，分1～2次口服，或根据年龄、症状适当增减，一日最高剂量不超过600mg。或遵医嘱！
禁用/慎用　

消化道损害患者，严重肝功能损害患者，或有肾功能损害史、过敏史者及支气管哮喘患者禁用。
不良反应　

①消化道：有时出现胃、腹部不适感，胃、腹痛，恶心呕吐食欲不振，便秘，腹泻。
②有时出现皮疹、瘙痒症。
③精神神经系统：有时出现嗜睡、头痛、头晕。
④肝脏：有时出现 GOT、GPT及ALT升高。
⑤其它：有时有浮肿、口内炎、舌裂、口渴、疲倦感、出汗、胸闷、耳鸣、眼睛朦胧。极少数出现尿沉淀的异常现象。
 
包装规格：

·600mg 100 锭
·600mg 100 片

Brand names: Daypro ALTA™, Daypro®

Chemical formula:

Oxaprozin Oral tablet

What is this medicine?

OXAPROZIN (ox a PROE zin) is a non-steroidal anti-inflammatory drug (NSAID). It is used to reduce swelling and to treat pain. It may be used for for rheumatoid arthritis, osteoarthritis, and juvenile rheumatoid arthritis.
 
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• asthma, especially aspirin sensitive asthma
• coronary artery bypass graft (CABG) surgery within the past 2 weeks
• drink more than 3 alcohol-containing drinks a day
• heart disease or circulation problems like heart failure or leg edema (fluid retention)
• high blood pressure
• kidney disease
• liver disease
• stomach bleeding or ulcers
• an unusual or allergic reaction to oxaprozin, aspirin, other NSAIDs, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Take this medicine by mouth with food and with a full glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed. Long-term, continuous use may increase the risk of heart attack or stroke.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 6 years of age for selected conditions, precautions do apply.

Elderly patients over 65 years old may have a stronger reaction and need a smaller dose.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
• cidofovir
• ketorolac
• methotrexate
• pemetrexed

This medicine may also interact with the following medications:
• alcohol
• aspirin and aspirin-like medicines
• cimetidine
• cyclosporine
• diuretics
• glyburide
• lithium
• medicines for high blood pressure
• medicines that affect platelets
• medicines that treat or prevent blood clots like warfarin
• NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
• ranitidine
• steroid medicines like prednisone or cortisone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor or health care professional if your pain does not get better. Talk to your doctor before taking another medicine for pain. Do not treat yourself.

This medicine does not prevent heart attack or stroke. In fact, this medicine may increase the chance of a heart attack or stroke. The chance may increase with longer use of this medicine and in people who have heart disease. If you take aspirin to prevent heart attack or stroke, talk with your doctor or health care professional.

Do not take medicines such as ibuprofen and naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medicines available without a prescription should not be taken with this medicine.

This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Do not smoke cigarettes or drink alcohol. These increase irritation to your stomach and can make it more susceptible to damage from this medicine. Ulcers and bleeding can happen without warning symptoms and can cause death.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

This medicine can cause you to bleed more easily. Try to avoid damage to your teeth and gums when you brush or floss your teeth.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• changes in vision
• chest pain
• difficulty breathing or wheezing
• nausea or vomiting
• redness, blistering, peeling or loosening of the skin, including inside the mouth
• severe abdominal pain
• slurred speech or weakness on one side of the body
• unexplained weight gain or swelling
• unusual bleeding or bruising
• unusually weak or tired
• yellowing of eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
• diarrhea
• dizziness
• headache
• heartburn

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Protect from light. Throw away any unused medicine after the expiration date.