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当前位置:药品说明书与价格首页 >> 肾脏病(尿毒症) >> 透析药品 >> Kiklin Capsules(Bixalomer 中文译名 踢磷胶囊)

Kiklin Capsules(Bixalomer 中文译名 踢磷胶囊)

2014-07-24 06:06:31  作者:新特药房  来源:互联网  浏览次数:446  文字大小:【】【】【
简介:英文药名:Kiklin Capsules(Bixalomer) 中文药名:踢磷胶囊 (比沙洛姆) 日文药名:キックリンカプセル 生产厂家:安斯泰来药品介绍高磷血症治疗剂(磷酸结合性聚合物)批准上市日期:2012年3月商標名Kikl ...

英文药名:Kiklin Capsules(Bixalomer)

中文药名:踢磷胶囊 (比沙洛姆)

生产厂家:安斯泰来制药

キックリンカプセル250mg

治疗类别名称
高磷血症治疗剂(磷酸结合性聚合物)
批准上市日期:2012年3月
商標名
Kiklin Capsules 250mg
一般名
ビキサロマー(Bixalomer)
本质
〔在日本名〕Bikisaroma,N,N,N',N'-四 - 二胺 - (3 - 氨丙基)丁烷-1,4(氯甲基)环氧乙烷的反应在1:2.1-2.4的比它是得到特的交联聚合物。
〔英文名称〕]Bixalomer是由N,N,N',N'-四(3 - 氨丙基)丁烷-1,4 - 二胺和2之间的反应得到的交联聚合物 - (氯甲基)环氧乙烷与一个比为1:2.1-2.4。
性状
它是一种白色粉末,淡黄色。和乙醇(99.5)和几乎不溶于水。是吸湿的。
药效药理
1. 药理作用
(1) 血浆磷浓度和Ca×P产品降血脂作用
在高磷减肥食品5/6肾切除慢性肾脏病鼠,Bikisaroma按3%的膳食管理,降低显著血浆磷浓度(AUC值)和Ca×P产品(AUC值)。此外,在腺嘌呤诱发慢性肾病大鼠,Bikisaroma由3%的膳食给药,显著降低血浆磷浓度(AUC值)和Ca×P产品(AUC值)。
(2) 血管钙化的抑制作用
维生素D的负载腺嘌呤诱发慢性肾病大鼠,Bikisaroma由2%的膳食给药,显著减少在主动脉钙的量。
(3)继发性甲状旁腺功能改进措施
在高磷减肥食品5/6肾切除慢性肾脏病鼠,Bikisaroma按3%的膳食管理,降低显著血浆浓度PTH(AUC值)和甲状旁腺的重量比。此外,在腺嘌呤诱发慢性肾病大鼠,Bikisaroma由3%的膳食给药,显著降低血浆PTH浓度(AUC值)和甲状旁腺重量比。
(4)肾性骨病进步抑制作用
在腺嘌呤诱发慢性肾病大鼠,Bikisaroma由3%的膳食管理,降低了股骨的间隙面积比和纤维化面积比。对于骨质面积比,没有观察到显著的变化,由于Bikisaroma施用。
(5)血液的pH值,对碳酸氢根离子浓度的作用
在腺嘌呤诱发慢性肾病大鼠,Bikisaroma由3%的膳食管理,是提高血液pH值和血碳酸氢根离子浓度的降低。
2. 作用机序
Bikisaroma是胺官能磷酸结合性聚合物,通过促进磷排泄到粪便结合磷酸盐在胃肠道中,从而减少了从胃肠道磷的吸收的抑制血磷浓度的。
适应症
用于治疗慢性肾病透析的高磷血症的药物
用法用量
每日3次,每次500mg,餐前服用。日最大剂量不超过7500mg。
包装规格
胶囊剂
250mg*100粒/盒(10粒×10)
250mg*500粒/盒(10粒×50)
制造商
安斯泰来制药公司
完整处方资料附件:http://www.info.pmda.go.jp/go/pack/2190032M1027_1_10/

本品优势:
A、与盐酸/碳酸司维拉姆、考来替兰相比,临床用药规格小,仅250mg/粒,服用量少,500mg/次,患者依从性会提高;
B、理化性质:吸水率和膨胀率低于盐酸司维拉姆,便秘和腹胀发生率更低;粘度低,流动性高,有利于合成、制剂制备;
C、疗效与盐酸司维拉姆相当,但不良反应低于盐酸司维拉姆,胃肠道不良反应低,不会降低碳酸氢盐水平或增加代谢酸中毒的风险;
Kiklin (Bixalomer) - 250mg (100 Capsules)

Brand Name: Kiklin
Generic Name: Bixalomer
Form: Capsules
Manufacturer: Astellas Pharma Inc
Please note: The product packaging is available in Japanese language only.
What is Kiklin?
Kiklin containing the active ingredient bixalomer is considered an amine functional polymers type of medication. It works by binding to phosphate in the gastrointestinal tract and decreasing the serum phosphorus concentration by inhibiting the absorption of phosphate into the human body. The medication is used to treat hyperphosphatemia in patients on dialysis with chronic kidney disease.
How is Kiklin used?
Kiklin is usually taken orally 2 capsules, 3 times per day or as directed by a doctor. The capsules should be taken just before meals along with some water. Contact a doctor for the correct dosage and length of treatment as it will depend on the patient�s condition and their response to the medication. The recommended maximum daily dosage is 7,500mg per day.
Adverse effects
Patients using Kiklin may encounter unwanted side effects such as:
Constipation
Ischemic colitis
Hemorrhagic intestinal diverticulum
Esophageal ulcer
Contact a doctor immediately should side effects persist or worsen.
Warnings
Immediately proceed to your nearest emergency department if you suffer an allergic reaction. Symptoms usually associated with such a reaction include difficulty breathing or swallowing, chest tightness, swelling, skin rashes, and hives.
Kiklin is not always suitable for all patients. Always consult your health care provider prior to using this medication if you are pregnant, breastfeeding, trying to conceive, using any other medication (prescription or non-prescription), using any herbal products or supplements, or if you have any allergies or other health problems.
The correct dosage and prescription commonly depend on the patient and the condition being treated. Do not adjust your dosage without the approval of your health care provider. This product is only for use as prescribed and instructed.

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