非那雄胺片剂(FINASTERIDE,PROSCAR)
简介:
Propecia (finasteride) is used to treat male pattern baldness (androgenic alopecia) in men. [It is also used in combination with doxazosin in the treatment of benign prostatic hyperplasia ...
Propecia (finasteride) is used to treat male pattern baldness (androgenic alopecia) in men. [It is also used in combination with doxazosin in the treatment of benign prostatic hyperplasia (BPH).] Finasteride is an orally active testosterone Type II 5-alpha reductase inhibitor, inhibiting the enzyme that converts testosterone to dihydrotestosterone (DHT). Topically (on the scalp itself) it is of some effect in minimizing further hair loss. In combination with Nizoral and spironolactone (which smells awful, by the way) it can actually reverse loss moderately. Oral use though will reduce DHT levels systemically, which may adversely affect training and sex drive. For use in cycles with testosterone, I don’t think it is bad at all. One simply doesn’t want less DHT than normal. As the amount of testosterone in the system increases, the amount of finasteride needed to keep levels down to normal increases. I consider 5 mg/day reasonable at the gram per week level, and proportionally less at lower dosages of testosterone. I personally wouldn’t use more than the recommended pharmaceutical dosage, or 5 mg/day. More might not be safe and might at some point cause DHT levels to become abnormally low. Finasteride is the chemical name of active ingredient in Proscar and Propecia. Proscar and Propecia are registered trademarks of Merck & Co. Inc. in the United States and/or other countries.
【药品名】:保列治(非那雄胺片) 【作用机理】非那雄胺是一种合成的甾体类化合物,它是雄激素睾酮代谢成为双氢睾酮过程中的细胞内酶Ⅱ型5α-还原酶的特异性抑制剂。非那雄胺对雄激素受体没有亲和力,也没有雄激素样、抗雄激素样、雌激素样、抗雌激素样或促孕作用。对该酶的抑制能阻碍外周组织中睾酮向雄激素双氢睾酮的转化,使血清及组织中双氢睾酮浓度显著下降。与安慰剂相比,可使血循环中睾酮的水平升高约10%-15%,但仍在生理范围内。非那雄胺能使血清中双氢睾酮浓度迅速下降,在给药后24小时内使之显著减少。 【适应症】保法止适用于治疗男性秃发(雄激素性秃发),能促进头发生长并防止继续脱发。 保法止不适用于妇女(参见孕妇和临床研究部分)和儿童。 【用法用量】推荐剂量为每天1次,1次1片(1mg),可与或不与食物同服。 一般在连续用药三个月或更长时间才能观察到头发生长增加,头发数目增加和/或防止继续脱发的效果。建议持续用药以取得最大疗效,停止用药后疗效可在12个月内发生逆转。 【不良反应】 上市后报告的不良事件如下:射精异常、乳房触痛和肿大、过敏反应(包括皮疹、瘙痒、荨麻疹和口唇肿胀)和睾丸疼痛。 【禁忌症】保法止禁用于: •孕妇或可能怀孕的妇女 •对本品任何成分过敏者 保法止不适用于妇女和儿童。 【药物相互作用】临床尚未发现重要的药物相互作用。非那雄胺不影响与细胞色素P450有关的药物代谢酶系。已在男性中研究过的药物包括安替比林、地高辛、优降糖、普奈洛尔、茶碱和华法令,未发现相互作用。 虽然尚未进行专门的相互作用研究,但在临床研究中,将1mg或大于1mg剂量的非那雄胺与血管紧张素转化酶抑制剂、对乙酰氨基酚、α受体阻断剂、苯二氮卓类、β受体阻断剂、钙通道阻滞剂、硝酸酯类、利尿剂、H2受体拮抗剂、β-羟基-β-甲基戊二酸单酰辅酶A还原酶抑制剂、前列腺素合成酶抑制剂及喹诺酮类合用,均未见重要的不良相互作用。 ----------------------------------------------------------------- 原产地英文商品名: PROSCAR-5mg/Tablet,30Tablets 原产地英文药品名: FINASTERIDE 中文参考商品译名: 保列治-5毫克/片,30片/盒 中文参考药品译名: 非那雄胺 产地国家: 英国 所属类别: 泌尿生殖系统及泌乳药物->前列腺疾病用药 处方药:处方药 包装规格: 5毫克/片,30片/盒 计价单位: 盒 原产地国家批准上市年份: 2001/01/30 英文适应病症1: Benign prostatic hyperplasia 英文适应病症2: BPH 英文适应病症3: Prostate 英文适应病症4: Urinary system 临床试验期: 完成 中文适应病症参考翻译1:
良性前列腺增生(症) 中文适应病症参考翻译2: 前列腺 中文适应病症参考翻译3: 泌尿系统
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